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30-Day Postoperative Complications After Surgical Treatment of Proximal Humerus Fractures: Reverse Total Shoulder Arthroplasty Versus Hemiarthroplasty.
Khazzam M, Ahn J, Sager B, Gates S, Sorich M, Boes N. Khazzam M, et al. Among authors: gates s. J Am Acad Orthop Surg Glob Res Rev. 2023 Mar 3;7(3):e22.00174. doi: 10.5435/JAAOSGlobal-D-22-00174. eCollection 2023 Mar 1. J Am Acad Orthop Surg Glob Res Rev. 2023. PMID: 36867524 Free PMC article.
Future studies are needed to determine whether there is a difference between these groups in the long-term outcome and survivorship of these implants....
Future studies are needed to determine whether there is a difference between these groups in the long-term outcome and survivorship o …
Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.
Perkins GD, Ji C, Achana F, Black JJ, Charlton K, Crawford J, de Paeztron A, Deakin C, Docherty M, Finn J, Fothergill RT, Gates S, Gunson I, Han K, Hennings S, Horton J, Khan K, Lamb S, Long J, Miller J, Moore F, Nolan J, O'Shea L, Petrou S, Pocock H, Quinn T, Rees N, Regan S, Rosser A, Scomparin C, Slowther A, Lall R. Perkins GD, et al. Among authors: gates s. Health Technol Assess. 2021 Apr;25(25):1-166. doi: 10.3310/hta25250. Health Technol Assess. 2021. PMID: 33861194 Free PMC article. Clinical Trial.
BACKGROUND: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term outcomes and concerns that it may cause worse neurological outcomes. ...In a community survey, 95% of people who responded thought that …
BACKGROUND: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term …
Long term outcomes of participants in the PARAMEDIC2 randomised trial of adrenaline in out-of-hospital cardiac arrest.
Haywood KL, Ji C, Quinn T, Nolan JP, Deakin CD, Scomparin C, Lall R, Gates S, Long J, Regan S, Fothergill RT, Pocock H, Rees N, O'Shea L, Perkins GD. Haywood KL, et al. Among authors: gates s. Resuscitation. 2021 Mar;160:84-93. doi: 10.1016/j.resuscitation.2021.01.019. Epub 2021 Jan 30. Resuscitation. 2021. PMID: 33524488 Clinical Trial.
AIMS: We recently reported early outcomes in patients enrolled in a randomised trial of adrenaline in out-of-hospital cardiac arrest: the PARAMEDIC2 (Prehospital Assessment of the Role of Adrenaline: Measuring the Effectiveness of Drug Administration in Cardiac Arrest) trial. The …
AIMS: We recently reported early outcomes in patients enrolled in a randomised trial of adrenaline in out-of-hospital cardiac arrest: the PA …
Is Protocolised Weaning that Includes Early Extubation Onto Non-Invasive Ventilation More Cost Effective Than Protocolised Weaning Without Non-Invasive Ventilation? Findings from the Breathe Study.
Khan I, Maredza M, Dritsaki M, Mistry D, Lall R, Lamb SE, Couper K, Gates S, Perkins GD, Petrou S; Breathe collaborators. Khan I, et al. Among authors: gates s. Pharmacoecon Open. 2020 Dec;4(4):697-710. doi: 10.1007/s41669-020-00210-1. Pharmacoecon Open. 2020. PMID: 32240532 Free PMC article.
Bivariate regression of costs and quality-adjusted life-years (QALYs) provided estimates of the incremental cost per QALY and incremental net monetary benefit (INMB) overall and for subgroups [presence/absence of chronic obstructive pulmonary disease (COPD) and operative status]. …
Bivariate regression of costs and quality-adjusted life-years (QALYs) provided estimates of the incremental cost per QALY and incremental ne …
Intraosseous versus intravenous administration of adrenaline in patients with out-of-hospital cardiac arrest: a secondary analysis of the PARAMEDIC2 placebo-controlled trial.
Nolan JP, Deakin CD, Ji C, Gates S, Rosser A, Lall R, Perkins GD. Nolan JP, et al. Among authors: gates s. Intensive Care Med. 2020 May;46(5):954-962. doi: 10.1007/s00134-019-05920-7. Epub 2020 Jan 30. Intensive Care Med. 2020. PMID: 32002593 Clinical Trial.
We could not detect any difference in the treatment effect between the IV and IO routes on the longer term outcomes of 30-day survival or favourable neurological outcome at discharge (ISRCTN73485024)....
We could not detect any difference in the treatment effect between the IV and IO routes on the longer term outcomes of 30-day surviva …
The influence of time to adrenaline administration in the Paramedic 2 randomised controlled trial.
Perkins GD, Kenna C, Ji C, Deakin CD, Nolan JP, Quinn T, Scomparin C, Fothergill R, Gunson I, Pocock H, Rees N, O'Shea L, Finn J, Gates S, Lall R. Perkins GD, et al. Among authors: gates s. Intensive Care Med. 2020 Mar;46(3):426-436. doi: 10.1007/s00134-019-05836-2. Epub 2020 Jan 7. Intensive Care Med. 2020. PMID: 31912202 Free PMC article. Clinical Trial.
As time to drug treatment increases, adrenaline increases the chances of return of spontaneous circulation. Longer term outcomes were not affected by the time to adrenaline administration. ...
As time to drug treatment increases, adrenaline increases the chances of return of spontaneous circulation. Longer term outcomes were …
The effects of adrenaline in out of hospital cardiac arrest with shockable and non-shockable rhythms: Findings from the PACA and PARAMEDIC-2 randomised controlled trials.
Perkins GD, Kenna C, Ji C, Deakin CD, Nolan JP, Quinn T, Fothergill R, Gunson I, Pocock H, Rees N, Charlton K, Finn J, Gates S, Lall R. Perkins GD, et al. Among authors: gates s. Resuscitation. 2019 Jul;140:55-63. doi: 10.1016/j.resuscitation.2019.05.007. Epub 2019 May 19. Resuscitation. 2019. PMID: 31116964
CONCLUSION: Relative to placebo, the effects of adrenaline ROSC are greater for patients with an initially non-shockable rhythm than those with a shockable rhythms. Similar patterns are observed for longer term survival outcomes and favourable neurological outcomes, althou …
CONCLUSION: Relative to placebo, the effects of adrenaline ROSC are greater for patients with an initially non-shockable rhythm than those w …
Non-invasive ventilation as a strategy for weaning from invasive mechanical ventilation: a systematic review and Bayesian meta-analysis.
Yeung J, Couper K, Ryan EG, Gates S, Hart N, Perkins GD. Yeung J, et al. Among authors: gates s. Intensive Care Med. 2018 Dec;44(12):2192-2204. doi: 10.1007/s00134-018-5434-z. Epub 2018 Oct 31. Intensive Care Med. 2018. PMID: 30382306 Free PMC article.
NIV weaning did not reduce overall hospital length of stay or long-term mortality. There were insufficient data to compare other adverse events and health-related quality of life. ...
NIV weaning did not reduce overall hospital length of stay or long-term mortality. There were insufficient data to compare other adve …
Liraglutide and Renal Outcomes in Type 2 Diabetes.
Mann JFE, Ørsted DD, Brown-Frandsen K, Marso SP, Poulter NR, Rasmussen S, Tornøe K, Zinman B, Buse JB; LEADER Steering Committee and Investigators. Mann JFE, et al. N Engl J Med. 2017 Aug 31;377(9):839-848. doi: 10.1056/NEJMoa1616011. N Engl J Med. 2017. PMID: 28854085 Free article. Clinical Trial.
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks of the primary …
BACKGROUND: In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with t …
Post-admission outcomes of participants in the PARAMEDIC trial: A cluster randomised trial of mechanical or manual chest compressions.
Ji C, Lall R, Quinn T, Kaye C, Haywood K, Horton J, Gordon V, Deakin CD, Pocock H, Carson A, Smyth M, Rees N, Han K, Byers S, Brace-McDonnell S, Gates S, Perkins GD; PARAMEDIC trial Collaborators. Ji C, et al. Among authors: gates s. Resuscitation. 2017 Sep;118:82-88. doi: 10.1016/j.resuscitation.2017.06.026. Epub 2017 Jul 5. Resuscitation. 2017. PMID: 28689046 Clinical Trial.
Hospital and intensive care length of stay were similar. Long term follow-up assessments were limited by poor response rates (53.7% at 3 months and 55.6% at 12 months). Follow-up rates were lower in those with worse neurological function. Among respondents, long term …
Hospital and intensive care length of stay were similar. Long term follow-up assessments were limited by poor response rates (53.7% a …
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