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Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic.
Galiana I, Lozano-Torres B, Sancho M, Alfonso M, Bernardos A, Bisbal V, Serrano M, Martínez-Máñez R, Orzáez M. Galiana I, et al. J Control Release. 2020 Jul 10;323:624-634. doi: 10.1016/j.jconrel.2020.04.045. Epub 2020 May 4. J Control Release. 2020. PMID: 32376460 Free article.
The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, limiting the long-term anti-tumorigenic effect of such drugs …
The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete im …