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Etoposide induces nuclear re-localisation of AID.
Lambert LJ, Walker S, Feltham J, Lee HJ, Reik W, Houseley J. Lambert LJ, et al. PLoS One. 2013 Dec 4;8(12):e82110. doi: 10.1371/journal.pone.0082110. eCollection 2013. PLoS One. 2013. PMID: 24324754 Free PMC article.
We conclude that DSB formation initiates a slow-acting pathway which allows stable long-term nuclear localisation of AID, and that such a pathway may enable AID-induced DNA demethylation during epigenetic reprogramming....
We conclude that DSB formation initiates a slow-acting pathway which allows stable long-term nuclear localisation of AID, and that su …
The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells.
Seisenberger S, Andrews S, Krueger F, Arand J, Walter J, Santos F, Popp C, Thienpont B, Dean W, Reik W. Seisenberger S, et al. Mol Cell. 2012 Dec 28;48(6):849-62. doi: 10.1016/j.molcel.2012.11.001. Epub 2012 Dec 6. Mol Cell. 2012. PMID: 23219530 Free PMC article.
Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry long-term epigenetic memory (imprints, CpG islands on the X chromosome, germline-specific genes) only become demethylated upon entry …
Global loss of methylation takes place during PGC expansion and migration with evidence for passive demethylation, but sequences that carry …