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Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics.
Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Wang Z, et al. Among authors: frosch mp. Acta Neuropathol Commun. 2023 Mar 10;11(1):39. doi: 10.1186/s40478-023-01511-2. Acta Neuropathol Commun. 2023. PMID: 36899414 Free PMC article.
Here we show that activity in this bioassay agrees relatively well with disruption of hippocampal long-term potentiation, a correlate of learning and memory, and that measurement of neurotoxic oAbeta can be obscured by more abundant non-toxic forms of Abeta. ...
Here we show that activity in this bioassay agrees relatively well with disruption of hippocampal long-term potentiation, a correlate …
Histopathological correlates of haemorrhagic lesions on ex vivo magnetic resonance imaging in immunized Alzheimer's disease cases.
Scherlek AA, Kozberg MG, Nicoll JAR, Perosa V, Freeze WM, van der Weerd L, Bacskai BJ, Greenberg SM, Frosch MP, Boche D, van Veluw SJ. Scherlek AA, et al. Among authors: frosch mp. Brain Commun. 2022 Feb 3;4(1):fcac021. doi: 10.1093/braincomms/fcac021. eCollection 2022. Brain Commun. 2022. PMID: 35224489 Free PMC article.
We hypothesized that these lesions would be associated with severe cerebral amyloid angiopathy. Ten cases were selected from the long-term follow-up study of patients who enrolled in the first clinical trial of active amyloid beta immunization with AN1792 for Alzheimer's d …
We hypothesized that these lesions would be associated with severe cerebral amyloid angiopathy. Ten cases were selected from the long-ter …
Association Between Immunosuppressive Treatment and Outcomes of Cerebral Amyloid Angiopathy-Related Inflammation.
Regenhardt RW, Thon JM, Das AS, Thon OR, Charidimou A, Viswanathan A, Gurol ME, Chwalisz BK, Frosch MP, Cho TA, Greenberg SM. Regenhardt RW, et al. Among authors: frosch mp. JAMA Neurol. 2020 Oct 1;77(10):1261-1269. doi: 10.1001/jamaneurol.2020.1782. JAMA Neurol. 2020. PMID: 32568365 Free PMC article.
These results raise the possibility that early blunting of CAA-ri and the autoimmune response may have long-term benefits for the subsequent disease course....
These results raise the possibility that early blunting of CAA-ri and the autoimmune response may have long-term benefits for the sub …
A vicious cycle of β amyloid-dependent neuronal hyperactivation.
Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. Zott B, et al. Among authors: frosch mp. Science. 2019 Aug 9;365(6453):559-565. doi: 10.1126/science.aay0198. Science. 2019. PMID: 31395777 Free PMC article.
Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.
Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Hong W, et al. Among authors: frosch mp. Acta Neuropathol. 2018 Jul;136(1):19-40. doi: 10.1007/s00401-018-1846-7. Epub 2018 Apr 23. Acta Neuropathol. 2018. PMID: 29687257 Free PMC article.
Here, we compared the abundance of Abeta in AD extracts prepared by traditional homogenization versus using a far gentler extraction, and assessed their bioactivity via real-time imaging of iPSC-derived human neurons plus the sensitive functional assay of long-term potenti …
Here, we compared the abundance of Abeta in AD extracts prepared by traditional homogenization versus using a far gentler extraction, and as …
Emerging concepts in sporadic cerebral amyloid angiopathy.
Charidimou A, Boulouis G, Gurol ME, Ayata C, Bacskai BJ, Frosch MP, Viswanathan A, Greenberg SM. Charidimou A, et al. Among authors: frosch mp. Brain. 2017 Jul 1;140(7):1829-1850. doi: 10.1093/brain/awx047. Brain. 2017. PMID: 28334869 Free PMC article. Review.
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related cognitive decline. The term 'cerebral amyloid angiopathy' now encompasses not only a specific cer …
Sporadic cerebral amyloid angiopathy is a common, well-defined small vessel disease and a largely untreatable cause of intracerebral haemorr …
Optical coherence tomography visualizes neurons in human entorhinal cortex.
Magnain C, Augustinack JC, Konukoglu E, Frosch MP, Sakadžić S, Varjabedian A, Garcia N, Wedeen VJ, Boas DA, Fischl B. Magnain C, et al. Among authors: frosch mp. Neurophotonics. 2015 Feb 9;2(1):015004. doi: 10.1117/1.NPh.2.1.015004. Neurophotonics. 2015. PMID: 25741528 Free PMC article.
With the future integration of a vibratome into the OCT imaging rig, this technique can be scaled up to obtain undistorted volumetric data of centimeter cube tissue blocks in the near term, and entire human hemispheres in the future....
With the future integration of a vibratome into the OCT imaging rig, this technique can be scaled up to obtain undistorted volumetric data o …
Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes.
Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P; Alzheimer's Disease Genetics Consortium; Cantwell LB, Dombroski BA, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Lunetta KL, Martin ER, Montine TJ, Goate AM, Blacker D, Tsuang DW, Beekly D, Cupples LA, Hakonarson H, Kukull W, Foroud TM, Haines J, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD. Jun G, et al. Arch Neurol. 2010 Dec;67(12):1473-84. doi: 10.1001/archneurol.2010.201. Epub 2010 Aug 9. Arch Neurol. 2010. PMID: 20697030 Free PMC article.
Models with the main SNP effect, presence or absence of APOE epsilon4, and an interaction term showed significant interaction between presence or absence of APOE epsilon4 and PICALM. ...
Models with the main SNP effect, presence or absence of APOE epsilon4, and an interaction term showed significant interaction between …
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