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An incoherent feedforward loop interprets NFκB/RelA dynamics to determine TNF-induced necroptosis decisions.
Oliver Metzig M, Tang Y, Mitchell S, Taylor B, Foreman R, Wollman R, Hoffmann A. Oliver Metzig M, et al. Among authors: foreman r. Mol Syst Biol. 2020 Dec;16(12):e9677. doi: 10.15252/msb.20209677. Mol Syst Biol. 2020. PMID: 33314666 Free PMC article.
Inducible expression of TNFAIP3/A20 forms an incoherent feedforward loop to interfere with the RIPK3-containing necrosome complex and protect a fraction of cells from transient, but not long-term TNF exposure. Furthermore, dysregulated NFkappaB dynamics often associated wi …
Inducible expression of TNFAIP3/A20 forms an incoherent feedforward loop to interfere with the RIPK3-containing necrosome complex and protec …
A 39-Year-Old Male Congenital Tricuspid Atresia Patient Who Presented with a New Axillary Lesion after an Orthotopic Heart Transplant.
Yu Z, Theodosakis N, Fitzpatrick MJ, Foreman RK, Mackool B. Yu Z, et al. Among authors: foreman rk. Dermatopathology (Basel). 2019 Oct 30;6(4):220-224. doi: 10.1159/000503661. eCollection 2019 Oct-Dec. Dermatopathology (Basel). 2019. PMID: 31828063 Free PMC article.
The condition most commonly affects patients with uncontrolled diabetes, HIV/AIDS, malignancy, and those receiving long-term immunosuppressive therapy. We report the case of a 39-year-old male with biopsy-proven cutaneous mucormycosis of the left axilla 4 months after an o …
The condition most commonly affects patients with uncontrolled diabetes, HIV/AIDS, malignancy, and those receiving long-term immunosu …
Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial.
Bonati LH, Dobson J, Featherstone RL, Ederle J, van der Worp HB, de Borst GJ, Mali WP, Beard JD, Cleveland T, Engelter ST, Lyrer PA, Ford GA, Dorman PJ, Brown MM; International Carotid Stenting Study investigators. Bonati LH, et al. Lancet. 2015 Feb 7;385(9967):529-38. doi: 10.1016/S0140-6736(14)61184-3. Epub 2014 Oct 14. Lancet. 2015. PMID: 25453443 Free PMC article. Clinical Trial.
BACKGROUND: Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy is uncertain. We report long-term data from the randomised International Carotid Stenting Study comparison of these treatments. ...The distribut …
BACKGROUND: Stenting is an alternative to endarterectomy for treatment of carotid artery stenosis, but long-term efficacy is uncertai …
The Brucella abortus general stress response system regulates chronic mammalian infection and is controlled by phosphorylation and proteolysis.
Kim HS, Caswell CC, Foreman R, Roop RM 2nd, Crosson S. Kim HS, et al. Among authors: foreman r. J Biol Chem. 2013 May 10;288(19):13906-16. doi: 10.1074/jbc.M113.459305. Epub 2013 Apr 1. J Biol Chem. 2013. PMID: 23546883 Free PMC article.
We conclude that the B. abortus GSR system regulates acute stress adaptation and long term survival within a mammalian host and that PhyR proteolysis is a novel regulatory feature in B. abortus that ensures proper control of GSR transcription....
We conclude that the B. abortus GSR system regulates acute stress adaptation and long term survival within a mammalian host and that …
Is constant current or constant voltage spinal cord stimulation superior for the suppression of nociceptive visceral and somatic stimuli? A rat model.
Qin C, Martinez M, Tang R, Huynh J, Goodman Keiser M, Farber JP, Carman JC, Wienecke GM, Niederauer G, Foreman RD. Qin C, et al. Among authors: foreman rd. Neuromodulation. 2012 Mar-Apr;15(2):132-42; discussion 143. doi: 10.1111/j.1525-1403.2012.00431.x. Epub 2012 Feb 24. Neuromodulation. 2012. PMID: 22364336
No significant differences were observed between the effects of CC- and CV-SCS on spontaneous activity and nociceptive responses of spinal neurons to noxious CRD following short- (five to ten minutes) or long-term (20-30 min) SCS. CONCLUSIONS: Although high-frequency CC- a …
No significant differences were observed between the effects of CC- and CV-SCS on spontaneous activity and nociceptive responses of spinal n …
Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial.
International Carotid Stenting Study investigators; Ederle J, Dobson J, Featherstone RL, Bonati LH, van der Worp HB, de Borst GJ, Lo TH, Gaines P, Dorman PJ, Macdonald S, Lyrer PA, Hendriks JM, McCollum C, Nederkoorn PJ, Brown MM. International Carotid Stenting Study investigators, et al. Lancet. 2010 Mar 20;375(9719):985-97. doi: 10.1016/S0140-6736(10)60239-5. Epub 2010 Feb 25. Lancet. 2010. PMID: 20189239 Free PMC article. Clinical Trial.
There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). INTERPRETATION: Completion of long-term follow-up is needed to establish the efficacy of carotid artery stenting compared with endarterectom …
There were also fewer haematomas of any severity in the stenting group than in the endarterectomy group (31 vs 50 events; p=0.0197). INTERPR …
Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R. Hanna J, et al. Among authors: foreman r. Cell. 2008 Apr 18;133(2):250-64. doi: 10.1016/j.cell.2008.03.028. Cell. 2008. PMID: 18423197 Free PMC article.
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with germline contribution, and to late-term embryos when injected into tetraploid blastocysts. Our study provides definite proof for the d …
Multiple iPS lines were clonally derived from both nonfully and fully differentiated B lymphocytes, which gave rise to adult chimeras with g …
Changes in urinary bladder smooth muscle function in response to colonic inflammation.
Noronha R, Akbarali H, Malykhina A, Foreman RD, Greenwood-Van Meerveld B. Noronha R, et al. Among authors: foreman rd. Am J Physiol Renal Physiol. 2007 Nov;293(5):F1461-7. doi: 10.1152/ajprenal.00311.2007. Epub 2007 Aug 22. Am J Physiol Renal Physiol. 2007. PMID: 17715261 Free article.
The goal of the present study was to investigate the short- and long-term effects of acute colitis on bladder detrusor muscle contractility. ...
The goal of the present study was to investigate the short- and long-term effects of acute colitis on bladder detrusor muscle contrac …
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.
Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. Wernig M, et al. Among authors: foreman r. Nature. 2007 Jul 19;448(7151):318-24. doi: 10.1038/nature05944. Epub 2007 Jun 6. Nature. 2007. PMID: 17554336
Notably, the cells-derived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can generate live late-term embryos when injected into tetraploid blastocysts. Our results show that the biological potency and epigenetic state of in-vitro-rep …
Notably, the cells-derived from mouse fibroblasts-can form viable chimaeras, can contribute to the germ line and can generate live late-t …
Long-term modulation of the intrinsic cardiac nervous system by spinal cord neurons in normal and ischaemic hearts.
Armour JA, Linderoth B, Arora RC, DeJongste MJ, Ardell JL, Kingma JG Jr, Hill M, Foreman RD. Armour JA, et al. Among authors: foreman rd. Auton Neurosci. 2002 Jan 10;95(1-2):71-9. doi: 10.1016/s1566-0702(01)00377-0. Auton Neurosci. 2002. PMID: 11873770
Electrical excitation of the dorsal aspect of the rostral thoracic spinal cord imparts long-term therapeutic benefits to patients with angina pectoris. Such spinal cord stimulation also induces short-term suppressor effects on the intrinsic cardiac nervous system. T …
Electrical excitation of the dorsal aspect of the rostral thoracic spinal cord imparts long-term therapeutic benefits to patients wit …
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