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Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results.
Youssef EA, Berry-Kravis E, Czech C, Hagerman RJ, Hessl D, Wong CY, Rabbia M, Deptula D, John A, Kinch R, Drewitt P, Lindemann L, Marcinowski M, Langland R, Horn C, Fontoura P, Santarelli L, Quiroz JA; FragXis Study Group. Youssef EA, et al. Among authors: deptula d. Neuropsychopharmacology. 2018 Feb;43(3):503-512. doi: 10.1038/npp.2017.177. Epub 2017 Aug 17. Neuropsychopharmacology. 2018. PMID: 28816242 Free PMC article. Clinical Trial.
Treatment of Fmr1 knockout mice with mGluR5-negative allosteric modulators (NAMs) has been reported to correct a broad range of phenotypes related to FXS. The early short-term clinical trials with mGluR5 NAMs, including basimglurant, assessing the effects in individuals wi …
Treatment of Fmr1 knockout mice with mGluR5-negative allosteric modulators (NAMs) has been reported to correct a broad range of phenotypes r …
Sexually-transmitted Infections and Unintended Pregnancy: A Longitudinal Analysis of Risk Transmission through Friends and Attitudes.
Henry DB, Deptula DP, Schoeny ME. Henry DB, et al. Among authors: deptula dp. Soc Dev. 2012 Feb 1;21(1):195-214. doi: 10.1111/j.1467-9507.2011.00626.x. Soc Dev. 2012. PMID: 22563148 Free PMC article.
Among males, there was evidence for selection effects on STI diagnoses and socialization effects on reports of unintended pregnancy, both involving friends' attitudes. Among females, there was evidence for long-term effects of both socialization and selection processes inv …
Among males, there was evidence for selection effects on STI diagnoses and socialization effects on reports of unintended pregnancy, both in …