Functional and evolutionary genomics of Mycobacterium tuberculosis: insights from genomic deletions in 100 strains.
Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4865-70. doi: 10.1073/pnas.0305634101. Epub 2004 Mar 15.
Proc Natl Acad Sci U S A. 2004.
PMID: 15024109
Free PMC article.
Although the deletions identified here are evidently inessential to the causation of disease (they are found in active clinical cases), their frequency spectrum suggests that most are weakly deleterious to the pathogen. For some deletions, short-term evolutionary pressure …
Although the deletions identified here are evidently inessential to the causation of disease (they are found in active clinical cases), thei …