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Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Neurobiol Dis. 2020 Jun;139:104823. doi: 10.1016/j.nbd.2020.104823. Epub 2020 Feb 28.
Neurobiol Dis. 2020.
PMID: 32119976
Free PMC article.
Review.
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations with three doses of AV-1959D. ...
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations wit …
Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology.
Joly-Amado A, Davtyan H, Serraneau K, Jules P, Zitnyar A, Pressman E, Zagorski K, Antonyan T, Hovakimyan A, Paek HJ, Gordon MN, Cribbs DH, Petrovsky N, Agadjanyan MG, Ghochikyan A, Morgan D.
Joly-Amado A, et al. Among authors: cribbs dh.
Neurobiol Dis. 2020 Feb;134:104636. doi: 10.1016/j.nbd.2019.104636. Epub 2019 Oct 17.
Neurobiol Dis. 2020.
PMID: 31629891
Free PMC article.
These experimental animals displayed an improvement in short-term memory during a novel object recognition test. However, impairments in other behavioral tasks were not prevented by AV-1980R/A vaccinations. ...
These experimental animals displayed an improvement in short-term memory during a novel object recognition test. However, impairments …
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Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral Deficits.
Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ.
Gold EM, et al. Among authors: cribbs dh.
ASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177/1759091418781921.
ASN Neuro. 2018.
PMID: 29932344
Free PMC article.
We have combined components of two classic rodent models of TBI, the controlled cortical impact model and the weight drop model, to develop a repeated mild closed head injury (rmCHI) that produces long-term deficits in several behaviors that correlate with neuropathologica …
We have combined components of two classic rodent models of TBI, the controlled cortical impact model and the weight drop model, to develop …
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Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques.
Evans CF, Davtyan H, Petrushina I, Hovakimyan A, Davtyan A, Hannaman D, Cribbs DH, Agadjanyan MG, Ghochikyan A.
Evans CF, et al. Among authors: cribbs dh.
Alzheimers Dement. 2014 May;10(3):284-95. doi: 10.1016/j.jalz.2013.04.505. Epub 2013 Jul 31.
Alzheimers Dement. 2014.
PMID: 23916838
Free PMC article.
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long-term, potent anti-Abeta antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Abeta. ...
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long- …
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Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1β via p38 mitogen-activated protein kinase.
Tong L, Prieto GA, Kramár EA, Smith ED, Cribbs DH, Lynch G, Cotman CW.
Tong L, et al. Among authors: cribbs dh.
J Neurosci. 2012 Dec 5;32(49):17714-24. doi: 10.1523/JNEUROSCI.1253-12.2012.
J Neurosci. 2012.
PMID: 23223292
Free PMC article.
Interleukin-1beta (IL-1beta), acting via poorly understood mechanisms, appears to be a key cytokine in causing these deleterious effects along with a presumably related loss of long-term potentiation (LTP)-type synaptic plasticity. We hypothesized that IL-1beta disrupts br …
Interleukin-1beta (IL-1beta), acting via poorly understood mechanisms, appears to be a key cytokine in causing these deleterious effects alo …
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