Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.
Hill JW, et al. Among authors: cowley ma.
J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964.
J Clin Invest. 2008.
PMID: 18382766
Free PMC article.
Despite these differences, mice with impaired PI3K signaling in POMC neurons exhibited normal long-term body weight regulation. Collectively, these results suggest that PI3K signaling in POMC neurons is essential for leptin-induced activation and insulin-induced inhibition …
Despite these differences, mice with impaired PI3K signaling in POMC neurons exhibited normal long-term body weight regulation. Colle …