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Current and emerging pharmacotherapies for obesity in Australia.
Hocking S, Dear A, Cowley MA. Hocking S, et al. Among authors: cowley ma. Obes Res Clin Pract. 2017 Sep-Oct;11(5):501-521. doi: 10.1016/j.orcp.2017.07.002. Epub 2017 Aug 14. Obes Res Clin Pract. 2017. PMID: 28818558 Review.
Of the new therapeutic options presented, all options have associated adverse events requiring long-term safety data, but the availability of new options is a welcome development....
Of the new therapeutic options presented, all options have associated adverse events requiring long-term safety data, but the availab …
Short-term high-fat diet increases the presence of astrocytes in the hypothalamus of C57BL6 mice without altering leptin sensitivity.
Balland E, Cowley MA. Balland E, et al. Among authors: cowley ma. J Neuroendocrinol. 2017 Oct;29(10). doi: 10.1111/jne.12504. J Neuroendocrinol. 2017. PMID: 28699230
Diet-induced obesity is associated with hypothalamic inflammation and this phenomenon has been proposed to explain leptin resistance. In the present study, we used a short-term high-fat diet (HFD) paradigm for 10 days and analysed the cellular and physiological responses t …
Diet-induced obesity is associated with hypothalamic inflammation and this phenomenon has been proposed to explain leptin resistance. In the …
Does leptin cause an increase in blood pressure in animals and humans?
Simonds SE, Pryor JT, Cowley MA. Simonds SE, et al. Among authors: cowley ma. Curr Opin Nephrol Hypertens. 2017 Jan;26(1):20-25. doi: 10.1097/MNH.0000000000000287. Curr Opin Nephrol Hypertens. 2017. PMID: 27798459 Review.
Here, we discuss the premise that leptin engages the sympathetic nervous system and contributes to elevated blood pressure (BP) developing in obesity. RECENT FINDINGS: The long-term regulation of BP is dependent on the activity of the autonomic nervous system and specifica …
Here, we discuss the premise that leptin engages the sympathetic nervous system and contributes to elevated blood pressure (BP) developing i …
Modified thresholds for fibrosis risk scores in nonalcoholic fatty liver disease are necessary in the obese.
Ooi GJ, Burton PR, Doyle L, Wentworth JM, Bhathal PS, Sikaris K, Cowley MA, Roberts SK, Kemp W, O'Brien PE, Brown WA. Ooi GJ, et al. Among authors: cowley ma. Obes Surg. 2017 Jan;27(1):115-125. doi: 10.1007/s11695-016-2246-5. Obes Surg. 2017. PMID: 27220852
BACKGROUND: Obesity and its related comorbidities are significant risk factors for nonalcoholic fatty liver disease (NAFLD). Liver fibrosis is the major determinant of long-term outcomes in NAFLD. A non-invasive tool that accurately identifies obese patients at elevated ri …
BACKGROUND: Obesity and its related comorbidities are significant risk factors for nonalcoholic fatty liver disease (NAFLD). Liver fibrosis …
Naltrexone/bupropion for obesity: an investigational combination pharmacotherapy for weight loss.
Billes SK, Sinnayah P, Cowley MA. Billes SK, et al. Among authors: cowley ma. Pharmacol Res. 2014 Jun;84:1-11. doi: 10.1016/j.phrs.2014.04.004. Epub 2014 Apr 19. Pharmacol Res. 2014. PMID: 24754973 Free article. Review.
The mechanism of action of the combination therapy, naltrexone/bupropion (NB), for obesity has not been fully described to date. Weight loss attempts rarely result in long-term success. This is likely a result of complex interactions among multiple peripheral and CNS syste …
The mechanism of action of the combination therapy, naltrexone/bupropion (NB), for obesity has not been fully described to date. Weight loss …
The role of pharmacotherapy in the prevention and treatment of paediatric metabolic syndrome--Implications for long-term health: part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.
Sabin MA, Magnussen CG, Juonala M, Cowley MA, Shield JP. Sabin MA, et al. Among authors: cowley ma. Pharmacol Res. 2012 Apr;65(4):397-401. doi: 10.1016/j.phrs.2011.10.003. Epub 2011 Oct 20. Pharmacol Res. 2012. PMID: 22037094
In children and adolescents, however, opportunities for pharmacotherapy are currently limited and interventions aimed at weight management remain the sole treatment paradigm in the majority of cases. This is primarily due to a lack of long-term data relating to the degree …
In children and adolescents, however, opportunities for pharmacotherapy are currently limited and interventions aimed at weight management r …
Comparison of combined bupropion and naltrexone therapy for obesity with monotherapy and placebo.
Greenway FL, Dunayevich E, Tollefson G, Erickson J, Guttadauria M, Fujioka K, Cowley MA; NB-201 Study Group. Greenway FL, et al. Among authors: cowley ma. J Clin Endocrinol Metab. 2009 Dec;94(12):4898-906. doi: 10.1210/jc.2009-1350. Epub 2009 Oct 21. J Clin Endocrinol Metab. 2009. PMID: 19846734 Clinical Trial.
CONCLUSIONS: NB caused gradual sustained weight loss over 48 wk; NB32 and NB16 demonstrated greater weight loss in the intent-to-treat population due to lower attrition rates. Further study is needed to demonstrate long-term efficacy and safety of NB....
CONCLUSIONS: NB caused gradual sustained weight loss over 48 wk; NB32 and NB16 demonstrated greater weight loss in the intent-to-treat popul …
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Hill JW, et al. Among authors: cowley ma. J Clin Invest. 2008 May;118(5):1796-805. doi: 10.1172/JCI32964. J Clin Invest. 2008. PMID: 18382766 Free PMC article.
Despite these differences, mice with impaired PI3K signaling in POMC neurons exhibited normal long-term body weight regulation. Collectively, these results suggest that PI3K signaling in POMC neurons is essential for leptin-induced activation and insulin-induced inhibition …
Despite these differences, mice with impaired PI3K signaling in POMC neurons exhibited normal long-term body weight regulation. Colle …
Zonisamide prevents olanzapine-associated hyperphagia, weight gain, and elevated blood glucose in rats.
Wallingford NM, Sinnayah P, Bymaster FP, Gadde KM, Krishnan RK, McKinney AA, Landbloom RP, Tollefson GD, Cowley MA. Wallingford NM, et al. Among authors: cowley ma. Neuropsychopharmacology. 2008 Nov;33(12):2922-33. doi: 10.1038/npp.2008.9. Epub 2008 Mar 5. Neuropsychopharmacology. 2008. PMID: 18322467
However, OLZ has also been associated with a higher incidence of weight gain than most other SGAs. Excessive weight gain may in turn contribute to long-term health concerns for some individuals. Zonisamide (ZNS), a medication approved in the United States as an adjunct in …
However, OLZ has also been associated with a higher incidence of weight gain than most other SGAs. Excessive weight gain may in turn contrib …
Excess weight gain during the early postnatal period is associated with permanent reprogramming of brown adipose tissue adaptive thermogenesis.
Xiao XQ, Williams SM, Grayson BE, Glavas MM, Cowley MA, Smith MS, Grove KL. Xiao XQ, et al. Among authors: cowley ma. Endocrinology. 2007 Sep;148(9):4150-9. doi: 10.1210/en.2007-0373. Epub 2007 May 24. Endocrinology. 2007. PMID: 17525123
Excess weight gain during the early postnatal period increases the risk of persistent obesity into adulthood and impacts on the subsequent risk for metabolic and cardiovascular diseases. The current study investigated the long-term effect of early excess weight gain, throu …
Excess weight gain during the early postnatal period increases the risk of persistent obesity into adulthood and impacts on the subsequent r …
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