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Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop.
Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Tian R, et al. Among authors: colucci ws. Circulation. 2019 Oct 1;140(14):1205-1216. doi: 10.1161/CIRCULATIONAHA.119.040551. Circulation. 2019. PMID: 31769940 Free PMC article. Review.
These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term …
These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research …
Short-term caloric restriction in db/db mice improves myocardial function and increases high molecular weight (HMW) adiponectin.
Xu XJ, Babo E, Qin F, Croteau D, Colucci WS. Xu XJ, et al. Among authors: colucci ws. IJC Metab Endocr. 2016 Dec;13:28-34. doi: 10.1016/j.ijcme.2016.10.002. Epub 2016 Oct 20. IJC Metab Endocr. 2016. PMID: 27942464 Free PMC article.
Furthermore, CR increased AMPK and eNOS activation in white adipose tissue of db/db mice, but not in the heart. CONCLUSIONS: These findings indicate that even short-term CR protects the heart from MHD. Whether the beneficial effects of CR on the heart could be related to t …
Furthermore, CR increased AMPK and eNOS activation in white adipose tissue of db/db mice, but not in the heart. CONCLUSIONS: These findings …
Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes.
Kuster GM, Lancel S, Zhang J, Communal C, Trucillo MP, Lim CC, Pfister O, Weinberg EO, Cohen RA, Liao R, Siwik DA, Colucci WS. Kuster GM, et al. Among authors: colucci ws. Free Radic Biol Med. 2010 May 1;48(9):1182-7. doi: 10.1016/j.freeradbiomed.2010.01.038. Epub 2010 Feb 1. Free Radic Biol Med. 2010. PMID: 20132882 Free PMC article.
We used an in vitro cardiomyocyte system to test the hypothesis that short-term oxidative stress induces SR Ca(2+) depletion via redox-mediated regulation of sarcoendoplasmic reticulum Ca(2+)-ATPase (SERCA) and the sodium-Ca(2+) exchanger (NCX) and that this is associated …
We used an in vitro cardiomyocyte system to test the hypothesis that short-term oxidative stress induces SR Ca(2+) depletion via redo …
L-arginine fails to prevent ventricular remodeling and heart failure in the spontaneously hypertensive rat.
Brooks WW, Conrad CH, Robinson KG, Colucci WS, Bing OH. Brooks WW, et al. Among authors: colucci ws. Am J Hypertens. 2009 Feb;22(2):228-34. doi: 10.1038/ajh.2008.334. Epub 2008 Dec 4. Am J Hypertens. 2009. PMID: 19057517
BACKGROUND: The effects of long-term oral administration of L-arginine, a substrate for nitric oxide (NO) production, on left ventricular (LV) remodeling, myocardial function and the prevention of heart failure (HF) was compared to the angiotensin-converting enzyme (ACE) i …
BACKGROUND: The effects of long-term oral administration of L-arginine, a substrate for nitric oxide (NO) production, on left ventric …
Impact of oxypurinol in patients with symptomatic heart failure. Results of the OPT-CHF study.
Hare JM, Mangal B, Brown J, Fisher C Jr, Freudenberger R, Colucci WS, Mann DL, Liu P, Givertz MM, Schwarz RP; OPT-CHF Investigators. Hare JM, et al. Among authors: colucci ws. J Am Coll Cardiol. 2008 Jun 17;51(24):2301-9. doi: 10.1016/j.jacc.2008.01.068. J Am Coll Cardiol. 2008. PMID: 18549913 Free article. Clinical Trial.
In a subgroup analysis, patients with elevated SUA (>9.5 mg/dl, n = 108) responded favorably to oxypurinol (p = 0.02 for interaction term), whereas oxypurinol patients with SUA <9.5 mg/dl exhibited a trend towards worsening. ...
In a subgroup analysis, patients with elevated SUA (>9.5 mg/dl, n = 108) responded favorably to oxypurinol (p = 0.02 for interaction t …
Effects of carvedilol early after myocardial infarction: analysis of the first 30 days in Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction (CAPRICORN).
Fonarow GC, Lukas MA, Robertson M, Colucci WS, Dargie HJ. Fonarow GC, et al. Among authors: colucci ws. Am Heart J. 2007 Oct;154(4):637-44. doi: 10.1016/j.ahj.2007.06.002. Am Heart J. 2007. PMID: 17892984 Clinical Trial.
CONCLUSIONS: In clinically stabilized post-MI patients with LVD, there is an early benefit with carvedilol treatment that is similar to that seen during long-term therapy....
CONCLUSIONS: In clinically stabilized post-MI patients with LVD, there is an early benefit with carvedilol treatment that is similar to that …
Cardioprotection: a new paradigm in the management of acute heart failure syndromes.
Maytin M, Colucci WS. Maytin M, et al. Among authors: colucci ws. Am J Cardiol. 2005 Sep 19;96(6A):26G-31G. doi: 10.1016/j.amjcard.2005.07.018. Am J Cardiol. 2005. PMID: 16181820 Review.
Although there are circumstantial data to suggest that the choice of therapeutic agent may affect long-term outcomes in such patients, the responsible mechanism is not known. ...
Although there are circumstantial data to suggest that the choice of therapeutic agent may affect long-term outcomes in such patients …
Sustained hemodynamic effects of intravenous levosimendan.
Kivikko M, Lehtonen L, Colucci WS. Kivikko M, et al. Among authors: colucci ws. Circulation. 2003 Jan 7;107(1):81-6. doi: 10.1161/01.cir.0000043245.00859.11. Circulation. 2003. PMID: 12515747 Clinical Trial.
BACKGROUND: The short-term infusion of levosimendan (Levo) improves hemodynamic function in patients with decompensated heart failure. ...The goal of this study was to determine whether the hemodynamic effects of Levo are sustained during a long-term infusion and be …
BACKGROUND: The short-term infusion of levosimendan (Levo) improves hemodynamic function in patients with decompensated heart failure …
Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial.
Cuffe MS, Califf RM, Adams KF Jr, Benza R, Bourge R, Colucci WS, Massie BM, O'Connor CM, Pina I, Quigg R, Silver MA, Gheorghiade M; Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) Investigators. Cuffe MS, et al. Among authors: colucci ws. JAMA. 2002 Mar 27;287(12):1541-7. doi: 10.1001/jama.287.12.1541. JAMA. 2002. PMID: 11911756 Clinical Trial.
Although intravenous inotropic therapy usually produces beneficial hemodynamic effects and is labeled for use in the care of such patients, the effect of such therapy on intermediate-term clinical outcomes is uncertain. OBJECTIVE: To prospectively test whether a strategy t …
Although intravenous inotropic therapy usually produces beneficial hemodynamic effects and is labeled for use in the care of such patients, …
Acute hemodynamic and clinical effects of levosimendan in patients with severe heart failure. Study Investigators.
Slawsky MT, Colucci WS, Gottlieb SS, Greenberg BH, Haeusslein E, Hare J, Hutchins S, Leier CV, LeJemtel TH, Loh E, Nicklas J, Ogilby D, Singh BN, Smith W. Slawsky MT, et al. Among authors: colucci ws. Circulation. 2000 Oct 31;102(18):2222-7. doi: 10.1161/01.cir.102.18.2222. Circulation. 2000. PMID: 11056096 Clinical Trial.
BACKGROUND: We determined the short-term hemodynamic and clinical effects of levosimendan, a novel calcium-sensitizing agent, in patients with decompensated heart failure. ...These hemodynamic effects appeared to be accompanied by symptom improvement and were not associate …
BACKGROUND: We determined the short-term hemodynamic and clinical effects of levosimendan, a novel calcium-sensitizing agent, in pati …
29 results