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Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
Aakre KM, Apple FS, Mills NL, Meex SJR, Collinson PO; International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB). Aakre KM, et al. Among authors: collinson po. Clin Chem. 2024 Mar 2;70(3):497-505. doi: 10.1093/clinchem/hvad185. Clin Chem. 2024. PMID: 38102065 Review.
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but requir …
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for lo …
Implementation of a high sensitivity cardiac troponin I assay and risk of myocardial infarction or death at five years: observational analysis of a stepped wedge, cluster randomised controlled trial.
Lee KK, Doudesis D, Ferry AV, Chapman AR, Kimenai DM, Fujisawa T, Bularga A, Lowry MTH, Taggart C, Schulberg S, Wereski R, Tuck C, Strachan FE, Newby DE, Anand A, Shah ASV, Mills NL; High-STEACS Investigators. Lee KK, et al. BMJ. 2023 Nov 27;383:e075009. doi: 10.1136/bmj-2023-075009. BMJ. 2023. PMID: 38011922 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients with suspected acute coronary syndrome. ...
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients w …
Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week.
Jaffe AS, Body R, Mills NL, Aakre KM, Collinson PO, Saenger A, Hammarsten O, Wereski R, Omland T, Sandoval Y, Ordonez-Llanos J, Apple FS; IFCC Committee on Cardiac Bio-Markers. Jaffe AS, et al. Among authors: collinson po. J Am Coll Cardiol. 2023 Jul 4;82(1):60-69. doi: 10.1016/j.jacc.2023.04.040. J Am Coll Cardiol. 2023. PMID: 37380305 Review.
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on presentation to exclude acute myocardial infarction with high clinical sensitivity and negative predictive value. ...
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on p …
Ischemia-modified albumin predicts short-term outcome and 1-year mortality in patients attending the emergency department for acute ischemic chest pain.
Consuegra-Sanchez L, Bouzas-Mosquera A, Sinha MK, Collinson PO, Gaze DC, Kaski JC. Consuegra-Sanchez L, et al. Among authors: collinson po. Heart Vessels. 2008 May;23(3):174-80. doi: 10.1007/s00380-007-1031-8. Epub 2008 May 17. Heart Vessels. 2008. PMID: 18484160
A total of 31 (15%) patients experienced the 30-day composite end point and 16 patients (7.7%) died during the 1-year follow-up. Short-term combined end point (9.6% vs 20.4%, P = 0.03) and 1-year mortality rate (11.7% vs 3.8%, log rank 3.978, P = 0.046) were significantly …
A total of 31 (15%) patients experienced the 30-day composite end point and 16 patients (7.7%) died during the 1-year follow-up. Short-te …
Defective endovascular trophoblast invasion in the first trimester is associated with increased maternal serum ischemia-modified albumin.
Papageorghiou AT, Prefumo F, Leslie K, Gaze DC, Collinson PO, Thilaganathan B. Papageorghiou AT, et al. Among authors: collinson po. Hum Reprod. 2008 Apr;23(4):803-6. doi: 10.1093/humrep/den029. Epub 2008 Feb 16. Hum Reprod. 2008. PMID: 18281685
First trimester maternal serum IMA concentrations in those subsequently developing pre-term pre-eclampsia (n = 19) were compared to randomly chosen controls with normal pregnancy outcome (n = 69). ...
First trimester maternal serum IMA concentrations in those subsequently developing pre-term pre-eclampsia (n = 19) were compared to r …
Meta-analysis of ischemia-modified albumin to rule out acute coronary syndromes in the emergency department.
Peacock F, Morris DL, Anwaruddin S, Christenson RH, Collinson PO, Goodacre SW, Januzzi JL, Jesse RL, Kaski JC, Kontos MC, Lefevre G, Mutrie D, Sinha MK, Uettwiller-Geiger D, Pollack CV. Peacock F, et al. Among authors: collinson po. Am Heart J. 2006 Aug;152(2):253-62. doi: 10.1016/j.ahj.2005.12.024. Am Heart J. 2006. PMID: 16875905
The TPT sensitivity and NPV for acute ACS were 94.4% and 97.1% and, for longer-term outcomes, were 89.2% and 94.5%, respectively. CONCLUSIONS: A negative TPT of a nondiagnostic electrocardiogram, negative troponin, and negative IMA has a high NPV for excluding ACS in the E …
The TPT sensitivity and NPV for acute ACS were 94.4% and 97.1% and, for longer-term outcomes, were 89.2% and 94.5%, respectively. CON …
Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes.
Stubbs PJ, Al-Obaidi MK, Conroy RM, Collinson PO, Graham IM, Noble IM. Stubbs PJ, et al. Among authors: collinson po. Circulation. 2000 Aug 8;102(6):605-10. doi: 10.1161/01.cir.102.6.605. Circulation. 2000. PMID: 10931798
We evaluated the relationship between plasma homocysteine and short-term (28 days) and long-term (median 2.5 years) prognosis in acute coronary syndromes. ...In the 203 unstable angina and 214 myocardial infarction survivors, an apparent threshold effect was seen on …
We evaluated the relationship between plasma homocysteine and short-term (28 days) and long-term (median 2.5 years) prognosis …
Troponin T or troponin I or CK-MB (or none?).
Collinson PO. Collinson PO. Eur Heart J. 1998 Nov;19 Suppl N:N16-24. Eur Heart J. 1998. PMID: 9857934
Improvements in diagnostic accuracy can reduce inappropriate long-term drug therapy. In systems with a more aggressive laboratory investigation strategy, rationalization of test numbers will provide an immediate cost reduction while improving quality. ...
Improvements in diagnostic accuracy can reduce inappropriate long-term drug therapy. In systems with a more aggressive laboratory inv …