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The inorganic NItrate and eXercise performance in Heart Failure (iNIX-HF) phase II clinical trial: Rationale and study design.
Coggan AR, Park LK, Racette SB, Davila-Roman VG, Lenzen P, Vehe K, Dore PM, Schechtman KB, Peterson LR. Coggan AR, et al. Contemp Clin Trials Commun. 2023 Oct 2;36:101208. doi: 10.1016/j.conctc.2023.101208. eCollection 2023 Dec. Contemp Clin Trials Commun. 2023. PMID: 37842318 Free PMC article.
The aim of this clinical trial (iNIX-HF) is to determine the acute and longer-term effectiveness of inorganic nitrate supplementation on exercise performance in patients with HF with reduced ejection fraction (HFrEF). ...Endpoints include the acute effects of a single dose …
The aim of this clinical trial (iNIX-HF) is to determine the acute and longer-term effectiveness of inorganic nitrate supplementation …
Short-term beetroot juice supplementation improves muscle speed and power but does not reduce blood pressure or oxidative stress in 65-79 y old men and women.
Zoughaib WS, Hoffman RL, Yates BA, Moorthi RN, Lim K, Coggan AR. Zoughaib WS, et al. Among authors: coggan ar. Nitric Oxide. 2023 Sep 1;138-139:34-41. doi: 10.1016/j.niox.2023.05.005. Epub 2023 May 25. Nitric Oxide. 2023. PMID: 37244392 Clinical Trial.
Using a double-blind, placebo-controlled, crossover design, we therefore studied 16 community-dwelling older (age 71 5 y) individuals after both acute and short-term (i.e., daily for 2 wk) BRJ supplementation. Blood samples were drawn and blood pressure was measured period …
Using a double-blind, placebo-controlled, crossover design, we therefore studied 16 community-dwelling older (age 71 5 y) individuals after …
A Diet Rich in Medium-Chain Fatty Acids Improves Systolic Function and Alters the Lipidomic Profile in Patients With Type 2 Diabetes: A Pilot Study.
Airhart S, Cade WT, Jiang H, Coggan AR, Racette SB, Korenblat K, Spearie CA, Waller S, O'Connor R, Bashir A, Ory DS, Schaffer JE, Novak E, Farmer M, Waggoner AD, Dávila-Román VG, Javidan-Nejad C, Peterson LR. Airhart S, et al. Among authors: coggan ar. J Clin Endocrinol Metab. 2016 Feb;101(2):504-12. doi: 10.1210/jc.2015-3292. Epub 2015 Dec 10. J Clin Endocrinol Metab. 2016. PMID: 26652763 Free PMC article. Clinical Trial.
CONCLUSIONS: Although a diet high in MCFAs does not change cardiac steatosis, our findings suggest that the MCFA-rich diet alters the plasma lipidome and may benefit or at least not harm cardiac function and fasting insulin levels in humans with type 2 diabetes. Larger, long-t …
CONCLUSIONS: Although a diet high in MCFAs does not change cardiac steatosis, our findings suggest that the MCFA-rich diet alters the plasma …
Ten days of exercise training reduces glucose production and utilization during moderate-intensity exercise.
Mendenhall LA, Swanson SC, Habash DL, Coggan AR. Mendenhall LA, et al. Among authors: coggan ar. Am J Physiol. 1994 Jan;266(1 Pt 1):E136-43. doi: 10.1152/ajpendo.1994.266.1.E136. Am J Physiol. 1994. PMID: 8304438

After 12 wk of training, Ra during exercise was further reduced to 21.5 +/- 3.1 mumol.min-1.kg-1 (P < 0.001 vs. 10 days), but hormone concentrations were not significantly different from 10-day values. The lower glucose Ra during exercise after short-term (10 days) trai

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After 12 wk of training, Ra during exercise was further reduced to 21.5 +/- 3.1 mumol.min-1.kg-1 (P < 0.001 vs. 10 days), but hormone con

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