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Association Between Ambient Air Pollution and Amyloid Positron Emission Tomography Positivity in Older Adults With Cognitive Impairment.
Iaccarino L, La Joie R, Lesman-Segev OH, Lee E, Hanna L, Allen IE, Hillner BE, Siegel BA, Whitmer RA, Carrillo MC, Gatsonis C, Rabinovici GD. Iaccarino L, et al. Among authors: carrillo mc. JAMA Neurol. 2021 Feb 1;78(2):197-207. doi: 10.1001/jamaneurol.2020.3962. JAMA Neurol. 2021. PMID: 33252608 Free PMC article.
Post hoc analyses showed no effect modification by sex (2002-2003: interaction term beta = 1.01 [95% CI, 0.99-1.04; z score = 1.13; FDR-corrected P = .56]; 2015-2016: beta = 1.02 [95% CI, 0.98-1.07; z score = 0.91; FDR-corrected P = .56]) or clinical stage (2002-2003: inte …
Post hoc analyses showed no effect modification by sex (2002-2003: interaction term beta = 1.01 [95% CI, 0.99-1.04; z score = 1.13; F …
Patient and Caregiver Assessment of the Benefits From the Clinical Use of Amyloid PET Imaging.
Mustafa R, Brosch JR, Rabinovici GD, Dickerson BC, Carrillo MC, Glazier BS, Gao S, Tierney M, Fargo KN, Austrom MG, De Santi S, Clark DG, Apostolova LG. Mustafa R, et al. Among authors: carrillo mc. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):35-42. doi: 10.1097/WAD.0000000000000220. Alzheimer Dis Assoc Disord. 2018. PMID: 29140859 Free PMC article.
Over 88% of respondents had a positive response (10% with neutral and 2% with negative responses) to whether amyloid PET should be offered routinely and be reimbursed. Such information was felt to be useful for long-term legal, financial, and health care planning. Responde …
Over 88% of respondents had a positive response (10% with neutral and 2% with negative responses) to whether amyloid PET should be offered r …
2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease.
Alzheimer's Association National Plan Milestone Workgroup; Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Yaffe K, Bain LJ, Thies WH, Carrillo MC. Alzheimer's Association National Plan Milestone Workgroup, et al. Among authors: carrillo mc. Alzheimers Dement. 2014 Oct;10(5 Suppl):S430-52. doi: 10.1016/j.jalz.2014.08.103. Alzheimers Dement. 2014. PMID: 25341459 Free article.
To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HHS also incorporated into the plan a set of short, medium and long-term milestones. HHS further committed to updating these milestones …
To guide investments, activities, and the measurement of progress toward achieving this 2025 goal, in its first annual plan update (2013) HH …
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR Jr, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, Thies B, Weintraub S, Phelps CH. McKhann GM, et al. Among authors: carrillo mc. Alzheimers Dement. 2011 May;7(3):263-9. doi: 10.1016/j.jalz.2011.03.005. Epub 2011 Apr 21. Alzheimers Dement. 2011. PMID: 21514250 Free PMC article.
On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the term possible AD dementia, but redefined it in a manner more focused than before. ...
On the basis of the past 27 years of experience, we made several changes in the clinical criteria for the diagnosis. We also retained the …
Neuroprotection by propargylamines in Parkinson's disease: suppression of apoptosis and induction of prosurvival genes.
Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, Naoi M. Maruyama W, et al. Among authors: carrillo mc. Neurotoxicol Teratol. 2002 Sep-Oct;24(5):675-82. doi: 10.1016/s0892-0362(02)00221-0. Neurotoxicol Teratol. 2002. PMID: 12200198 Review.
Rasagiline prevented the PT in mitochondria directly and also indirectly through induction of antiapoptotic Bcl-2 and a neurotrophic factor, glial cell line-derived neurotrophic factor (GDNF). Long-term administration of propargylamines to rats increased the activities of …
Rasagiline prevented the PT in mitochondria directly and also indirectly through induction of antiapoptotic Bcl-2 and a neurotrophic factor, …
Mechanism underlying anti-apoptotic activity of a (-)deprenyl-related propargylamine, rasagiline.
Maruyama W, Yamamoto T, Kitani K, Carrillo MC, Youdim M, Naoi M. Maruyama W, et al. Among authors: carrillo mc. Mech Ageing Dev. 2000 Jul 31;116(2-3):181-91. doi: 10.1016/s0047-6374(00)00144-5. Mech Ageing Dev. 2000. PMID: 10996018
A potent inhibitor of type B monoamine oxidase, (-)deprenyl, is known to protect or rescue dying neurons, independent of inhibition of the enzyme activity. After long term administration to rodents, a propargylamine structurally related to (-)deprenyl, (R)(+)-N-propargyl-1 …
A potent inhibitor of type B monoamine oxidase, (-)deprenyl, is known to protect or rescue dying neurons, independent of inhibition of the e …
Assessing the effects of deprenyl on longevity and antioxidant defenses in different animal models.
Kitani K, Kanai S, Ivy GO, Carrillo MC. Kitani K, et al. Among authors: carrillo mc. Ann N Y Acad Sci. 1998 Nov 20;854:291-306. doi: 10.1111/j.1749-6632.1998.tb09910.x. Ann N Y Acad Sci. 1998. PMID: 9928438 Review.
We have observed, however, significantly positive effects on SOD (in Cu, Zn-, and Mn-) as well as CAT (but not glutathione peroxidase) activities in the brain dopaminergic system such as in the S. nigra and striatum (but not in hippocampus) in all rats, mice, and dogs, although t …
We have observed, however, significantly positive effects on SOD (in Cu, Zn-, and Mn-) as well as CAT (but not glutathione peroxidase) activ …
Upregulation of antioxidant enzyme activities by deprenyl. Implications for life span extension.
Kitani K, Miyasaka K, Kanai S, Carrillo MC, Ivy GO. Kitani K, et al. Among authors: carrillo mc. Ann N Y Acad Sci. 1996 Jun 15;786:391-409. doi: 10.1111/j.1749-6632.1996.tb39079.x. Ann N Y Acad Sci. 1996. PMID: 8687037
Continued subcutaneous infusion of deprenyl for 3 weeks caused a 2-3-fold increase in activities of both Cu Zn- and Mn-SOD and a 50-60% increase in CAT activities in striatum and substantia nigra but not in hippocampus, cerebellum or the liver. Further, long-term treatment …
Continued subcutaneous infusion of deprenyl for 3 weeks caused a 2-3-fold increase in activities of both Cu Zn- and Mn-SOD and a 50-60% incr …
Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain.
Carrillo MC, Kitani K, Kanai S, Sato Y, Ivy GO, Miyasaka K. Carrillo MC, et al. Life Sci. 1996;59(13):1047-57. doi: 10.1016/0024-3205(96)00420-1. Life Sci. 1996. PMID: 8809224
Together with the results from our previous study with short term (-)deprenyl treatment in old mice, these results replicate our previous findings in old female rats. We showed that longer term treatment with (-)deprenyl reduces the optimal dose for increasing antio …
Together with the results from our previous study with short term (-)deprenyl treatment in old mice, these results replicate our prev …
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