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Investigator-led clinical research consortia: the Canadian Critical Care Trials Group.
Marshall JC, Cook DJ; Canadian Critical Care Trials Group. Marshall JC, et al. Crit Care Med. 2009 Jan;37(1 Suppl):S165-72. doi: 10.1097/CCM.0b013e3181921079. Crit Care Med. 2009. PMID: 19104219
Its members have been highly successful in obtaining funding for, completing, and publishing well-designed studies that have informed international practice in areas such as transfusion, stress ulcer prophylaxis, long term outcomes from acute respiratory distress syndrome, …
Its members have been highly successful in obtaining funding for, completing, and publishing well-designed studies that have informed intern …
Sex differences in thromboprophylaxis of the critically ill: a secondary analysis of a randomized trial.
Burns KEA, Heels-Ansdell D, Thabane L, Kahn SR, Lauzier F, Mehta S, Ostermann M, Bhuptani P, Crowther MA, Finfer S, Cook DJ; PROTECT Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Burns KEA, et al. Can J Anaesth. 2023 Jun;70(6):1008-1018. doi: 10.1007/s12630-023-02457-8. Epub 2023 Jun 13. Can J Anaesth. 2023. PMID: 37310606 Clinical Trial. English.
METHODS: We conducted unadjusted analyses using Cox proportional hazards analysis, stratified by centre and admission diagnostic category, including sex, treatment, and an interaction term. Additionally, we performed adjusted analyses and assessed the credibility of our fi …
METHODS: We conducted unadjusted analyses using Cox proportional hazards analysis, stratified by centre and admission diagnostic category, i …
Clinically important venous thromboembolism in pediatric critical care: a Canadian survey.
Kotsakis A, Cook D, Griffith L, Anton N, Massicotte P, MacFarland K, Farrell R, Hutchison J; Canadian Critical Care Trials Group. Kotsakis A, et al. J Crit Care. 2005 Dec;20(4):373-80. doi: 10.1016/j.jcrc.2005.09.012. J Crit Care. 2005. PMID: 16310610
MATERIALS AND METHODS: Our definition of clinically important VTE was a VTE likely to result in short- or long-term morbidity or mortality if left untreated. We asked respondents to rate the likelihood that patient factors and radiological features make a venous thrombosis …
MATERIALS AND METHODS: Our definition of clinically important VTE was a VTE likely to result in short- or long-term morbidity or mort …
Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study.
Bosma KJ, Martin CM, Burns KEA, Mancebo Cortes J, Suárez Montero JC, Skrobik Y, Thorpe KE, Amaral ACK, Arabi Y, Basmaji J, Beduneau G, Beloncle F, Carteaux G, Charbonney E, Demoule A, Dres M, Fanelli V, Geagea A, Goligher E, Lellouche F, Maraffi T, Mercat A, Rodriguez PO, Shahin J, Sibley S, Spadaro S, Vaporidi K, Wilcox ME, Brochard L; Canadian Critical Care Trials Group and; REVA Network. Bosma KJ, et al. Trials. 2023 Mar 27;24(1):232. doi: 10.1186/s13063-023-07163-w. Trials. 2023. PMID: 36973743 Free PMC article.
The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload within a normal range. Short-term and physiological benefits of this mode compared to pressure support ventilation (PSV) include better p …
The proportional assistance, called the gain, can be adjusted by the clinician to maintain the patient's respiratory effort or workload with …
Safety of cell therapy with mesenchymal stromal cells (SafeCell): a systematic review and meta-analysis of clinical trials.
Lalu MM, McIntyre L, Pugliese C, Fergusson D, Winston BW, Marshall JC, Granton J, Stewart DJ; Canadian Critical Care Trials Group. Lalu MM, et al. PLoS One. 2012;7(10):e47559. doi: 10.1371/journal.pone.0047559. Epub 2012 Oct 25. PLoS One. 2012. PMID: 23133515 Free PMC article. Review.
The primary outcome adverse events were grouped according to immediate events (acute infusional toxicity, fever), organ system complications, infection, and longer term adverse events (death, malignancy). 2347 citations were reviewed and 36 studies met inclusion criteria. …
The primary outcome adverse events were grouped according to immediate events (acute infusional toxicity, fever), organ system complications …
Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol.
Turgeon AF, Fergusson DA, Clayton L, Patton MP, Zarychanski R, English S, Docherty A, Walsh T, Griesdale D, Kramer AH, Scales D, Burns KEA, Boyd JG, Marshall JC, Kutsogiannis DJ, Ball I, Hébert PC, Lamontagne F, Costerousse O, St-Onge M, Lessard Bonaventure P, Moore L, Neveu X, Rigamonti A, Khwaja K, Green RS, Laroche V, Fox-Robichaud A, Lauzier F; HEMOTION Trial Team, the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Turgeon AF, et al. BMJ Open. 2022 Oct 10;12(10):e067117. doi: 10.1136/bmjopen-2022-067117. BMJ Open. 2022. PMID: 36216432 Free PMC article.
INTRODUCTION: Traumatic brain injury (TBI) is the leading cause of mortality and long-term disability in young adults. Despite the high prevalence of anaemia and red blood cell transfusion in patients with TBI, the optimal haemoglobin (Hb) transfusion threshold is unknown. …
INTRODUCTION: Traumatic brain injury (TBI) is the leading cause of mortality and long-term disability in young adults. Despite the hi …
Partial ventilatory support modalities in acute lung injury and acute respiratory distress syndrome-a systematic review.
McMullen SM, Meade M, Rose L, Burns K, Mehta S, Doyle R, Henzler D; Canadian Critical Care Trials Group (CCCTG). McMullen SM, et al. PLoS One. 2012;7(8):e40190. doi: 10.1371/journal.pone.0040190. Epub 2012 Aug 16. PLoS One. 2012. PMID: 22916094 Free PMC article. Review.
CONCLUSIONS: The use of partial ventilatory support modalities is often feasible in patients with ALI/ARDS, and may be associated with short-term physiological benefits without appreciable impact on clinically important outcomes....
CONCLUSIONS: The use of partial ventilatory support modalities is often feasible in patients with ALI/ARDS, and may be associated with short …
Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study.
Teo K, Fowler RA, Adhikari NKJ, Rishu A, Tsang JLY, Binnie A, Murthy S; Canadian Critical Care Trials Group. Teo K, et al. CMAJ Open. 2023 Jul 4;11(4):E615-E620. doi: 10.9778/cmajo.20220129. Print 2023 Jul-Aug. CMAJ Open. 2023. PMID: 37402556 Free PMC article.
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term funding of platform trials that engage academic and community hospitals are potential solutions to improve trial start-up efficiency....
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term fu …
Cardiac arrhythmias associated with severe traumatic brain injury and hypothermia therapy.
Bourdages M, Bigras JL, Farrell CA, Hutchison JS, Lacroix J; Canadian Critical Care Trials Group. Bourdages M, et al. Pediatr Crit Care Med. 2010 May;11(3):408-14. Pediatr Crit Care Med. 2010. PMID: 20464781 Clinical Trial.
The objective is to determine the effect of moderate and short-term (24 hrs) hypothermia therapy on the incidence and severity of cardiac arrhythmias in children with severe traumatic brain injury compared with normothermic control subject using a 24-hr Holter recording. . …
The objective is to determine the effect of moderate and short-term (24 hrs) hypothermia therapy on the incidence and severity of car …
A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards.
Daneman N, Rishu AH, Pinto R, Arabi Y, Belley-Cote EP, Cirone R, Downing M, Cook DJ, Hall R, McGuinness S, McIntyre L, Muscedere J, Parke R, Reynolds S, Rogers BA, Shehabi Y, Shin P, Whitlock R, Fowler RA; Canadian Critical Care Trials Group. Daneman N, et al. Trials. 2020 Jan 15;21(1):92. doi: 10.1186/s13063-019-4033-9. Trials. 2020. PMID: 31941546 Free PMC article. Clinical Trial.
20 results