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A multi-country analysis of COVID-19 hospitalizations by vaccination status.
Gonçalves BP, Jassat W, Baruch J, Hashmi M, Rojek A, Dasgupta A, Martin-Loeches I, Reyes LF, Piubelli C, Citarella BW, Kartsonaki C, Lefèvre B, López Revilla JW, Lunn M, Harrison EM, Kraemer MUG, Shrapnel S, Horby P, Bisoffi Z, Olliaro PL, Merson L; ISARIC Clinical Characterisation Group. Gonçalves BP, et al. Med. 2023 Nov 10;4(11):797-812.e2. doi: 10.1016/j.medj.2023.08.005. Epub 2023 Sep 21. Med. 2023. PMID: 37738979 Free PMC article.
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term international studies to characterize changes in clinical profile of hospitalized COVID-19 patients related to vaccination history. ...
CONCLUSIONS: These findings will inform allocation of healthcare resources in future surges as well as design of longer-term internat …
A natural variation-based screen in mouse cells reveals USF2 as a regulator of the DNA damage response and cellular senescence.
Kang T, Moore EC, Kopania EEK, King CD, Schilling B, Campisi J, Good JM, Brem RB. Kang T, et al. Among authors: campisi j. G3 (Bethesda). 2023 Jul 5;13(7):jkad091. doi: 10.1093/g3journal/jkad091. G3 (Bethesda). 2023. PMID: 37097016 Free PMC article.
In acute irradiation experiments, cells lacking USF2 had compromised DNA damage repair and response. Longer-term senescent cultures without USF2 mounted an exaggerated senescence regulatory program-shutting down cell cycle and DNA repair pathways, and turning up cytokine e …
In acute irradiation experiments, cells lacking USF2 had compromised DNA damage repair and response. Longer-term senescent cultures w …
Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.
Kuehnemann C, Hughes JB, Desprez PY, Melov S, Wiley CD, Campisi J. Kuehnemann C, et al. Among authors: campisi j. Aging Cell. 2023 Jan;22(1):e13750. doi: 10.1111/acel.13750. Epub 2022 Dec 20. Aging Cell. 2023. PMID: 36539941 Free PMC article.
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. However, long-term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nuc …
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. How …
Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.
Writing Committee for the REMAP-CAP Investigators; Higgins AM, Berry LR, Lorenzi E, Murthy S, McQuilten Z, Mouncey PR, Al-Beidh F, Annane D, Arabi YM, Beane A, van Bentum-Puijk W, Bhimani Z, Bonten MJM, Bradbury CA, Brunkhorst FM, Burrell A, Buzgau A, Buxton M, Charles WN, Cove M, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Girard TD, Goligher EC, Goossens H, Haniffa R, Hills T, Horvat CM, Huang DT, Ichihara N, Lamontagne F, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McVerry BJ, Neal MD, Nichol AD, Parke RL, Parker JC, Parry-Billings K, Peters SEC, Reyes LF, Rowan KM, Saito H, Santos MS, Saunders CT, Serpa-Neto A, Seymour CW, Shankar-Hari M, Stronach LM, Turgeon AF, Turner AM, van de Veerdonk FL, Zarychanski R, Green C, Lewis RJ, Angus DC, McArthur CJ, Berry S, Derde LPG, Gordon AC, Webb SA, Lawler PR. Writing Committee for the REMAP-CAP Investigators, et al. JAMA. 2023 Jan 3;329(1):39-51. doi: 10.1001/jama.2022.23257. JAMA. 2023. PMID: 36525245 Free PMC article.
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. DESIGN, SETTING, AN …
IMPORTANCE: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. OBJECTIVE: T …
Social media use while listening to new material negatively affects short-term memory in college students.
Spence A, Beasley K, Gravenkemper H, Hoefler A, Ngo A, Ortiz D, Campisi J. Spence A, et al. Among authors: campisi j. Physiol Behav. 2020 Dec 1;227:113172. doi: 10.1016/j.physbeh.2020.113172. Epub 2020 Sep 17. Physiol Behav. 2020. PMID: 32950505 Clinical Trial.
Therefore, in the current study we examined if social media use during or after being presented new information affected short-term memory in college students. Additionally, we assessed if the type or quantity of topics displayed had a modulatory impact on memory. ...Subje …
Therefore, in the current study we examined if social media use during or after being presented new information affected short-term m …
Strategies to Prevent or Remediate Cancer and Treatment-Related Aging.
Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, Dietrich J, Fuldner R, Gallicchio L, Green PA, Hurria A, Janelsins MC, Jhappan C, Kirkland JL, Kohanski R, Longo V, Meydani S, Mohile S, Niedernhofer LJ, Nelson C, Perna F, Schadler K, Scott JM, Schrack JA, Tracy RP, van Deursen J, Ness KK. Guida JL, et al. Among authors: campisi j. J Natl Cancer Inst. 2021 Feb 1;113(2):112-122. doi: 10.1093/jnci/djaa060. J Natl Cancer Inst. 2021. PMID: 32348501 Free PMC article.
The meeting identified research and resource needs, including geroscience-guided clinical trials; comprehensive assessments of functional, cognitive, and psychosocial vulnerabilities to assess and predict age-related outcomes; preclinical and clinical research to determine the op …
The meeting identified research and resource needs, including geroscience-guided clinical trials; comprehensive assessments of functional, c …
Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors.
Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O'Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A. Guida JL, et al. Among authors: campisi j. J Natl Cancer Inst. 2019 Dec 1;111(12):1245-1254. doi: 10.1093/jnci/djz136. J Natl Cancer Inst. 2019. PMID: 31321426 Free PMC article.
In aggregate, cancer- and treatment-related physical, cognitive, and psychosocial late- and long-term morbidities experienced by cancer survivors are hypothesized to represent accelerated or accentuated aging trajectories. ...Through the resulting deliberations, several re …
In aggregate, cancer- and treatment-related physical, cognitive, and psychosocial late- and long-term morbidities experienced by canc …
Epithelial innate immunity mediates tubular cell senescence after kidney injury.
Jin H, Zhang Y, Ding Q, Wang SS, Rastogi P, Dai DF, Lu D, Purvis M, Cao C, Wang A, Liu D, Ren C, Elhadi S, Hu MC, Chai Y, Zepeda-Orozco D, Campisi J, Attanasio M. Jin H, et al. Among authors: campisi j. JCI Insight. 2019 Jan 24;4(2):e125490. doi: 10.1172/jci.insight.125490. JCI Insight. 2019. PMID: 30674725 Free PMC article.
Our data reveal a cell-autonomous role for epithelial innate immunity in controlling TEC senescence after kidney injury, and additionally suggest that early therapeutic intervention is required for effective reduction of long-term sequelae of AKI....
Our data reveal a cell-autonomous role for epithelial innate immunity in controlling TEC senescence after kidney injury, and additionally su …
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Among authors: campisi j. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, in …
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist a …
Placental membrane aging and HMGB1 signaling associated with human parturition.
Menon R, Behnia F, Polettini J, Saade GR, Campisi J, Velarde M. Menon R, et al. Among authors: campisi j. Aging (Albany NY). 2016 Feb;8(2):216-30. doi: 10.18632/aging.100891. Aging (Albany NY). 2016. PMID: 26851389 Free PMC article.
Here, we investigated whether cellular senescence-the loss of cell division potential as a consequence of stress-is involved in placental membrane function at term. We show telomere reduction, p38 MAPK activation, increase in p21 expression, loss of lamin B1 loss, increase …
Here, we investigated whether cellular senescence-the loss of cell division potential as a consequence of stress-is involved in placental me …
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