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The natural history of medication compliance in a drug trial: limitations of pill counts.
Rudd P, Byyny RL, Zachary V, LoVerde ME, Titus C, Mitchell WD, Marshall G. Rudd P, et al. Among authors: byyny rl. Clin Pharmacol Ther. 1989 Aug;46(2):169-76. doi: 10.1038/clpt.1989.122. Clin Pharmacol Ther. 1989. PMID: 2667837 Clinical Trial.
We concluded that weekly pill counts indicated marked intersubject and intrasubject variability, obscured by long-term averages; that compliance lapses appeared to be random; and that excessive medication-taking was the most consistent with "pill dumping."...
We concluded that weekly pill counts indicated marked intersubject and intrasubject variability, obscured by long-term averages; that …