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Data-driven systematic analysis of waterborne viruses and health risks during the wastewater reclamation process.
Ma JX, Wang X, Pan YR, Wang ZY, Guo X, Liu J, Ren NQ, Butler D. Ma JX, et al. Among authors: butler d. Environ Sci Ecotechnol. 2023 Oct 6;19:100328. doi: 10.1016/j.ese.2023.100328. eCollection 2024 May. Environ Sci Ecotechnol. 2023. PMID: 37965045 Free PMC article.
This study focused on identifying viral epidemic patterns in municipal wastewater reused for recreational applications based on long-term, spatially explicit global literature data during 2000-2021, and modelled human health risks from multiple exposure pathways using a we …
This study focused on identifying viral epidemic patterns in municipal wastewater reused for recreational applications based on long-term …
Resistance to PRMT5-targeted therapy in mantle cell lymphoma.
Long ME, Koirala S, Sloan S, Brown-Burke F, Weigel C, Villagomez L, Corps K, Sharma A, Hout I, Harper M, Helmig-Mason J, Tallada S, Chen Z, Scherle P, Vaddi K, Chen-Kiang S, Di Liberto M, Meydan C, Foox J, Butler D, Mason C, Alinari L, Blaser BW, Baiocchi R. Long ME, et al. Among authors: butler d. Blood Adv. 2024 Jan 9;8(1):150-163. doi: 10.1182/bloodadvances.2023010554. Blood Adv. 2024. PMID: 37782774 Free PMC article.

Bulk RNA sequencing of resistant cell lines and PDX relative to sensitive or short-term-treated cells, respectively, highlighted shared upregulation of multiple pathways including mechanistic target of rapamycin kinase [mTOR] signaling (P < 10-5 and z score > 0.3 or

…
Bulk RNA sequencing of resistant cell lines and PDX relative to sensitive or short-term-treated cells, respectively, highlighted shar …
Large-scale capture of hidden fluorescent labels for training generalizable markerless motion capture models.
Butler DJ, Keim AP, Ray S, Azim E. Butler DJ, et al. Nat Commun. 2023 Sep 26;14(1):5866. doi: 10.1038/s41467-023-41565-3. Nat Commun. 2023. PMID: 37752123 Free PMC article.
Moreover, due to inherent limitations in manual annotation, only a sparse set of landmarks are typically labeled. To address these issues, we developed an approach, which we term GlowTrack, for generating orders of magnitude more training data, enabling models that general …
Moreover, due to inherent limitations in manual annotation, only a sparse set of landmarks are typically labeled. To address these issues, w …
Global resilience analysis of combined sewer systems under continuous hydrologic simulation.
Rodriguez M, Fu G, Butler D, Yuan Z, Cook L. Rodriguez M, et al. Among authors: butler d. J Environ Manage. 2023 Oct 15;344:118607. doi: 10.1016/j.jenvman.2023.118607. Epub 2023 Jul 13. J Environ Manage. 2023. PMID: 37453297 Free article.
., rainfall) and impacts (e.g., CSOs) through continuous and long-term simulation, accommodating various rainfall patterns, including extreme events. ...
., rainfall) and impacts (e.g., CSOs) through continuous and long-term simulation, accommodating various rainfall patterns, including …
Neonatal subarachnoid hemorrhage disrupts multiple aspects of cerebellar development.
Butler DF, Skibo J, Traudt CM, Millen KJ. Butler DF, et al. Front Mol Neurosci. 2023 Apr 28;16:1161086. doi: 10.3389/fnmol.2023.1161086. eCollection 2023. Front Mol Neurosci. 2023. PMID: 37187957 Free PMC article.
To address this gap in knowledge, we developed a novel model of early isolated posterior fossa subarachnoid hemorrhage (SAH) in neonatal mice and investigated both acute and long-term effects. Following SAH on postnatal day 6 (P6), we found significant decreased levels of …
To address this gap in knowledge, we developed a novel model of early isolated posterior fossa subarachnoid hemorrhage (SAH) in neonatal mic …
Treatment Strategies for Chronic Pruritus and Eczema/Dermatitis in Older Adults Under the Category of Chronic Eczematous Eruptions of Aging (CEEA).
Shahin TB, Sreekantaswamy SA, Hawkes JE, Butler DC. Shahin TB, et al. Among authors: butler dc. Am J Clin Dermatol. 2023 May;24(3):405-418. doi: 10.1007/s40257-023-00767-7. Epub 2023 Mar 15. Am J Clin Dermatol. 2023. PMID: 36920748 Review.
The literature has not yet established a single ubiquitous disease or term for these eruptions in adults over the age of 65 years. Instead, CEEA is attributed various names, including immunologic eruption of aging, and eruption of immunosenescence. ...
The literature has not yet established a single ubiquitous disease or term for these eruptions in adults over the age of 65 years. In …
Neonatal Subarachnoid Hemorrhage Disrupts Multiple Aspects of Cerebellar Development.
Butler DF, Skibo J, Traudt CM, Millen KJ. Butler DF, et al. bioRxiv [Preprint]. 2023 Feb 10:2023.02.10.528048. doi: 10.1101/2023.02.10.528048. bioRxiv. 2023. PMID: 36798230 Free PMC article. Updated. Preprint.
To address this gap in knowledge, we developed a novel model of early isolated posterior fossa subarachnoid hemorrhage (SAH) in neonatal mice and investigated both acute and long-term effects. Following SAH on postnatal day 6 (P6), we found significant decreased levels of …
To address this gap in knowledge, we developed a novel model of early isolated posterior fossa subarachnoid hemorrhage (SAH) in neonatal mic …
Evolution of functional tissue engineering for tendon and ligament repair.
Butler DL. Butler DL. J Tissue Eng Regen Med. 2022 Dec;16(12):1091-1108. doi: 10.1002/term.3360. Epub 2022 Nov 17. J Tissue Eng Regen Med. 2022. PMID: 36397198 Review.
This review emphasizes the need for broader and more inclusive collaborations by surgeons, biologists and engineers in the short term with involvement of those in biomaterials, manufacturing, and regulation of new products in the longer term....
This review emphasizes the need for broader and more inclusive collaborations by surgeons, biologists and engineers in the short term …
TauLUM, an in vivo Drosophila sensor of tau multimerization, identifies neuroprotective interventions in tauopathy.
Levy SA, Zuniga G, Gonzalez EM, Butler D, Temple S, Frost B. Levy SA, et al. Among authors: butler d. Cell Rep Methods. 2022 Sep 9;2(9):100292. doi: 10.1016/j.crmeth.2022.100292. eCollection 2022 Sep 19. Cell Rep Methods. 2022. PMID: 36160048 Free PMC article.
In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term "tau(LUM)," allows investigators to quantify tau multimerization at individual time points or longitudinally in adult, living animals housed in a 9 …
In the current study, we develop a Drosophila split-luciferase-based sensor of tau-tau interaction. This model, which we term "tau(LU …
Outcomes and endpoints in clinical trials supporting the marketing authorisation of treatments in paediatric acute lymphoblastic leukaemia.
Micallef B, Nistico R, Bjerrum OW, Sarac SB, Butler D, Serracino-Inglott A, Borg JJ. Micallef B, et al. Among authors: butler d. Drug Discov Today. 2022 Sep;27(9):2440-2466. doi: 10.1016/j.drudis.2022.05.015. Epub 2022 May 18. Drug Discov Today. 2022. PMID: 35597514 Review.
Survival and response rates remain the most-prevalent endpoints in paediatric ALL research, but other intermediate clinical endpoints and molecular biomarkers for efficacy and mid- and long-term safety endpoints are also being investigated. The success of current ALL treat …
Survival and response rates remain the most-prevalent endpoints in paediatric ALL research, but other intermediate clinical endpoints and mo …
56 results