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The influence of a supervised group exercise intervention combined with active lifestyle recommendations on breast cancer survivors' health, physical functioning, and quality of life indices: study protocol for a randomized and controlled trial.
Riani Costa LA, F Barreto R, de Leandrini SMM, Gurgel ARB, de Sales GT, Voltarelli VA, de Castro G Jr, Fenton SAM, Turner JE, Klausener C, Neves LM, Ugrinowitsch C, Farah JC, Forjaz CLM, Brito CMM, Brum PC. Riani Costa LA, et al. Among authors: brum pc. Trials. 2021 Dec 18;22(1):934. doi: 10.1186/s13063-021-05843-z. Trials. 2021. PMID: 34922621 Free PMC article.
Studies have shown that both supervised exercise and unsupervised physical activity programs have low adherence and limited long-term benefits among cancer survivors. Therefore, interventions focused on increasing physical activity levels have clinical and psychological re …
Studies have shown that both supervised exercise and unsupervised physical activity programs have low adherence and limited long-term …
Chronic Sympathetic Hyperactivity Triggers Electrophysiological Remodeling and Disrupts Excitation-Contraction Coupling in Heart.
Joca HC, Santos-Miranda A, Joviano-Santos JV, Maia-Joca RPM, Brum PC, Williams GSB, Cruz JS. Joca HC, et al. Among authors: brum pc. Sci Rep. 2020 May 14;10(1):8001. doi: 10.1038/s41598-020-64949-7. Sci Rep. 2020. PMID: 32409748 Free PMC article.
Prolonged adrenergic receptor activation, however, has deleterious long-term effects leading to hypertrophy and the development of heart failure. ...
Prolonged adrenergic receptor activation, however, has deleterious long-term effects leading to hypertrophy and the development of he …
Moderate Continuous Aerobic Exercise Training Improves Cardiomyocyte Contractility in Β1 Adrenergic Receptor Knockout Mice.
Rodrigues AC, Natali AJ, Cunha DNQD, Costa AJLD, Moura AG, Araújo Carneiro-Júnior M, Félix LB, Brum PC, Prímola-Gomes TN. Rodrigues AC, et al. Among authors: brum pc. Arq Bras Cardiol. 2018 Mar;110(3):256-262. doi: 10.5935/abc.20180025. Epub 2018 Feb 19. Arq Bras Cardiol. 2018. PMID: 29466489 Free PMC article.
BACKGROUND: The lack of cardiac beta1-adrenergic receptors (beta1-AR) negatively affects the regulation of both cardiac inotropy and lusitropy, leading, in the long term, to heart failure (HF). Moderate-intensity aerobic exercise (MCAE) is recommended as an adjunctive ther …
BACKGROUND: The lack of cardiac beta1-adrenergic receptors (beta1-AR) negatively affects the regulation of both cardiac inotropy and lusitro …
Loss of strength capacity is associated with mortality, but resistance exercise training promotes only modest effects during cachexia progression.
das Neves W, Alves CR, de Almeida NR, Guimarães FL, Ramires PR, Brum PC, Lancha AH Jr. das Neves W, et al. Among authors: brum pc. Life Sci. 2016 Oct 15;163:11-22. doi: 10.1016/j.lfs.2016.08.025. Epub 2016 Aug 26. Life Sci. 2016. PMID: 27575705
However, the role of RET to counteract cancer cachexia is still speculative. This study aimed to verify whether short-term RET would counteract skeletal muscle wasting in a severe cancer cachexia rat model. ...SIGNIFICANCE: These results demonstrated that bone marrow injec …
However, the role of RET to counteract cancer cachexia is still speculative. This study aimed to verify whether short-term RET would …
Overnutrition during lactation leads to impairment in insulin signaling, up-regulation of GLUT1 and increased mitochondrial carbohydrate oxidation in heart of weaned mice.
Bernardo AF, Cortez E, Neves FA, Vieira AK, Soares Vde M, Rodrigues-Cunha AC, Andrade DC, Thole AA, Gabriel-Costa D, Brum PC, Moura AS, Garcia-Souza ÉP. Bernardo AF, et al. Among authors: brum pc. J Nutr Biochem. 2016 Mar;29:124-32. doi: 10.1016/j.jnutbio.2015.09.021. Epub 2015 Oct 3. J Nutr Biochem. 2016. PMID: 26608021
Several studies have demonstrated that overnutrition during early postnatal period can increase the long-term risk of developing obesity and cardiac disorders, yet the short-term effects of postnatal overfeeding in cardiac metabolism remains unknown. ...In conclusio …
Several studies have demonstrated that overnutrition during early postnatal period can increase the long-term risk of developing obes …
Long-term aerobic exercise protects against cisplatin-induced nephrotoxicity by modulating the expression of IL-6 and HO-1.
Miyagi MY, Seelaender M, Castoldi A, de Almeida DC, Bacurau AV, Andrade-Oliveira V, Enjiu LM, Pisciottano M, Hayashida CY, Hiyane MI, Brum PC, Camara NO, Amano MT. Miyagi MY, et al. Among authors: brum pc. PLoS One. 2014 Oct 1;9(10):e108543. doi: 10.1371/journal.pone.0108543. eCollection 2014. PLoS One. 2014. PMID: 25272046 Free PMC article.
Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Giα-coupled β2-adrenoceptor signaling pathway.
Davel AP, Brum PC, Rossoni LV. Davel AP, et al. Among authors: brum pc. PLoS One. 2014 Mar 12;9(3):e91877. doi: 10.1371/journal.pone.0091877. eCollection 2014. PLoS One. 2014. PMID: 24622771 Free PMC article.
CONCLUSIONS: The beta2-adrenoceptor/Gialpha signaling pathway is implicated in the enhanced vasoconstrictor response and eNOS uncoupling-mediated oxidative stress due to ISO treatment. Thus, long-term beta2-AR activation might results in endothelial dysfunction....
CONCLUSIONS: The beta2-adrenoceptor/Gialpha signaling pathway is implicated in the enhanced vasoconstrictor response and eNOS uncoupling-med …
High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats.
Moreira JB, Bechara LR, Bozi LH, Jannig PR, Monteiro AW, Dourado PM, Wisløff U, Brum PC. Moreira JB, et al. Among authors: brum pc. J Appl Physiol (1985). 2013 Apr;114(8):1029-41. doi: 10.1152/japplphysiol.00760.2012. Epub 2013 Feb 21. J Appl Physiol (1985). 2013. PMID: 23429866 Free article.
Poor skeletal muscle performance was shown to strongly predict mortality and long-term prognosis in a variety of diseases, including heart failure (HF). ...
Poor skeletal muscle performance was shown to strongly predict mortality and long-term prognosis in a variety of diseases, including …
Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats.
da Luz PL, Tanaka L, Brum PC, Dourado PM, Favarato D, Krieger JE, Laurindo FR. da Luz PL, et al. Among authors: brum pc. Atherosclerosis. 2012 Sep;224(1):136-42. doi: 10.1016/j.atherosclerosis.2012.06.007. Epub 2012 Jun 26. Atherosclerosis. 2012. PMID: 22818625
OBJECTIVE: To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to 0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. ...
OBJECTIVE: To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to 0.15 mg% r …
Impact of 6 months of therapy with carvedilol on muscle sympathetic nerve activity in heart failure patients.
De Matos LD, Gardenghi G, Rondon MU, Soufen HN, Tirone AP, Barretto AC, Brum PC, Middlekauff HR, Negrão CE. De Matos LD, et al. Among authors: brum pc. J Card Fail. 2004 Dec;10(6):496-502. doi: 10.1016/j.cardfail.2004.03.006. J Card Fail. 2004. PMID: 15599840 Clinical Trial.
BACKGROUND: The long-term effects of carvedilol on muscle sympathetic nerve activity (MSNA) and muscle blood flow at rest and exercise in patients with chronic heart failure (CHF) remain unknown. ...
BACKGROUND: The long-term effects of carvedilol on muscle sympathetic nerve activity (MSNA) and muscle blood flow at rest and exercis …