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Neurostimulation for Advanced Parkinson Disease and Quality of Life at 5 Years: A Nonrandomized Controlled Trial.
Jost ST, Aloui S, Evans J, Ashkan K, Sauerbier A, Rizos A, Petry-Schmelzer JN, Gronostay A, Fink GR, Visser-Vandewalle V, Antonini A, Silverdale M, Timmermann L, Martinez-Martin P, Chaudhuri KR, Dafsari HS; International Parkinson and Movement Disorders Society Non-Motor Parkinson’s Disease Study Group and EUROPAR. Jost ST, et al. JAMA Netw Open. 2024 Jan 2;7(1):e2352177. doi: 10.1001/jamanetworkopen.2023.52177. JAMA Netw Open. 2024. PMID: 38236600 Free PMC article. Clinical Trial.
However, controlled studies with more than 3 years of follow-up are lacking. OBJECTIVE: To investigate the long-term effects of STN-DBS on QOL compared with standard-of-care medication (MED). ...The association between changes in QOL and ADL, but not motor impairment or co …
However, controlled studies with more than 3 years of follow-up are lacking. OBJECTIVE: To investigate the long-term effects of STN-D …
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice.
Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U, Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN. Sato T, et al. Among authors: brooks dj. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2214396119. doi: 10.1073/pnas.2214396119. Epub 2022 Dec 6. Proc Natl Acad Sci U S A. 2022. PMID: 36472957 Free PMC article.
Furthermore, SK-124 treatment increased bone formation by osteoblasts and boosted trabecular bone mass without evidence of short-term toxicity. Taken together, these findings demonstrate PTH-like effects in bone and mineral metabolism upon in vivo treatment with orally ava …
Furthermore, SK-124 treatment increased bone formation by osteoblasts and boosted trabecular bone mass without evidence of short-term …
In vivo vesicular acetylcholine transporter density in human peripheral organs: an [18F]FEOBV PET/CT study.
Horsager J, Okkels N, Van Den Berge N, Jacobsen J, Schact A, Munk OL, Vang K, Bender D, Brooks DJ, Borghammer P. Horsager J, et al. Among authors: brooks dj. EJNMMI Res. 2022 Apr 1;12(1):17. doi: 10.1186/s13550-022-00889-9. EJNMMI Res. 2022. PMID: 35362761 Free PMC article.
Registered 31 May 2018. https://clinicaltrials.gov/ct2/show/NCT03554551?term=NCT03554551&draw=2&rank=1 ....
Registered 31 May 2018. https://clinicaltrials.gov/ct2/show/NCT03554551?term=NCT03554551&draw=2&rank=1 ....
Beneficial effect of 24-month bilateral subthalamic stimulation on quality of sleep in Parkinson's disease.
Dafsari HS, Ray-Chaudhuri K, Ashkan K, Sachse L, Mahlstedt P, Silverdale M, Rizos A, Strack M, Jost ST, Reker P, Samuel M, Visser-Vandewalle V, Evans J, Antonini A, Martinez-Martin P, Timmermann L; EUROPAR, the IPMDS Non Motor P.D. Study Group. Dafsari HS, et al. J Neurol. 2020 Jun;267(6):1830-1841. doi: 10.1007/s00415-020-09743-1. Epub 2020 Mar 9. J Neurol. 2020. PMID: 32152689 Free PMC article.
BACKGROUND: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's disease (PD). However, the long-term effects of STN-DBS on sleep and its relationship with QoL outcome are unclear. ...
BACKGROUND: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and sleep symptoms in Parkinson's …
Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.
Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomašević Z, Denduluri N, Šeparović R, Gokmen E, Bashford A, Ruiz Borrego M, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M, Chan A; ExteNET Study Group. Martin M, et al. Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13. Lancet Oncol. 2017. PMID: 29146401 Clinical Trial.
Treatment-emergent serious adverse events occurred in 103 (7%) women in the neratinib group and 85 (6%) women in the placebo group. No evidence of increased risk of long-term toxicity or long-term adverse consequences of neratinib-associated diarrhoea were identifie …
Treatment-emergent serious adverse events occurred in 103 (7%) women in the neratinib group and 85 (6%) women in the placebo group. No evide …
Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: a case-control study.
Stokholm MG, Iranzo A, Østergaard K, Serradell M, Otto M, Svendsen KB, Garrido A, Vilas D, Borghammer P, Santamaria J, Møller A, Gaig C, Brooks DJ, Tolosa E, Pavese N. Stokholm MG, et al. Among authors: brooks dj. Lancet Neurol. 2017 Oct;16(10):789-796. doi: 10.1016/S1474-4422(17)30173-4. Epub 2017 Jul 3. Lancet Neurol. 2017. PMID: 28684245
Further studies, including more participants than were in this study and longitudinal follow-up, are needed to support our findings and evaluate whether the presence of activated microglia in patients with IRBD represents a marker of short-term conversion to a clinically d …
Further studies, including more participants than were in this study and longitudinal follow-up, are needed to support our findings and eval …
Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice.
Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Ko FC, et al. Among authors: brooks dj. J Bone Miner Res. 2017 Apr;32(4):814-820. doi: 10.1002/jbmr.3052. Epub 2017 Jan 17. J Bone Miner Res. 2017. PMID: 27925290 Free PMC article.
Bisphosphonates are being increasingly used to treat pediatric patients with skeletal disorders. However, the effects of long-term bisphosphonate therapy and cessation of therapy during growth are unclear. ...
Bisphosphonates are being increasingly used to treat pediatric patients with skeletal disorders. However, the effects of long-term bi …
Amyloid pathology and axonal injury after brain trauma.
Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJ. Scott G, et al. Among authors: brooks dj. Neurology. 2016 Mar 1;86(9):821-8. doi: 10.1212/WNL.0000000000002413. Epub 2016 Feb 3. Neurology. 2016. PMID: 26843562 Free PMC article.
OBJECTIVE: To image beta-amyloid (Abeta) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic axonal injury and Abeta are correlated, and compare the spatial distribution of Abeta to Alzheimer disease (AD). ...
OBJECTIVE: To image beta-amyloid (Abeta) plaque burden in long-term survivors of traumatic brain injury (TBI), test whether traumatic …
Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study.
Nombela C, Rowe JB, Winder-Rhodes SE, Hampshire A, Owen AM, Breen DP, Duncan GW, Khoo TK, Yarnall AJ, Firbank MJ, Chinnery PF, Robbins TW, O'Brien JT, Brooks DJ, Burn DJ; ICICLE-PD study group; Barker RA. Nombela C, et al. Among authors: brooks dj. Brain. 2014 Oct;137(Pt 10):2743-58. doi: 10.1093/brain/awu201. Epub 2014 Jul 30. Brain. 2014. PMID: 25080285 Free PMC article.
Longitudinal data will confirm the extent to which these early neurocognitive changes, and their genetic factors, influence the long-term risk of dementia in Parkinson's disease. The combination of genetics and functional neuroimaging provides a potentially useful method f …
Longitudinal data will confirm the extent to which these early neurocognitive changes, and their genetic factors, influence the long-term …
Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP.
Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A. Riaño Barros DA, et al. Among authors: brooks dj. Neuroimage. 2014 Aug 15;97:151-62. doi: 10.1016/j.neuroimage.2014.04.020. Epub 2014 Apr 13. Neuroimage. 2014. PMID: 24736184 Free PMC article.
We used seven quantification methods: reversible compartmental models with one and two tissue classes, two and four rate constants, and a variable blood volume term (2kbv; 4kbv); model-free (spectral) analyses with and without regularisation, including one with voxel-wise …
We used seven quantification methods: reversible compartmental models with one and two tissue classes, two and four rate constants, and a va …
34 results