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Bioinspired Theranostic Coordination Polymer Nanoparticles for Intranasal Dopamine Replacement in Parkinson's Disease.
García-Pardo J, Novio F, Nador F, Cavaliere I, Suárez-García S, Lope-Piedrafita S, Candiota AP, Romero-Gimenez J, Rodríguez-Galván B, Bové J, Vila M, Lorenzo J, Ruiz-Molina D. García-Pardo J, et al. Among authors: bove j. ACS Nano. 2021 May 25;15(5):8592-8609. doi: 10.1021/acsnano.1c00453. Epub 2021 Apr 22. ACS Nano. 2021. PMID: 33885286 Free PMC article.
Symptomatic therapy for PD has been centered in the precursor l-DOPA administration, an amino acid precursor of DA that crosses the blood-brain barrier (BBB) while DA does not, although this approach presents medium- to long-term side effects. To overcome this limitation, …
Symptomatic therapy for PD has been centered in the precursor l-DOPA administration, an amino acid precursor of DA that crosses the blood-br …
Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson's disease patients.
Recasens A, Carballo-Carbajal I, Parent A, Bové J, Gelpi E, Tolosa E, Vila M. Recasens A, et al. Among authors: bove j. Acta Neuropathol Commun. 2018 Feb 8;6(1):8. doi: 10.1186/s40478-018-0509-1. Acta Neuropathol Commun. 2018. PMID: 29422109 Free PMC article.
In contrast to our previous findings using nigral LB extracts, intracerebral inoculation of SG-derived LB into mice did not trigger long-term nigrostriatal neurodegeneration nor alpha-synuclein pathology. ...
In contrast to our previous findings using nigral LB extracts, intracerebral inoculation of SG-derived LB into mice did not trigger long- …
Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells.
Sánchez-Danés A, Consiglio A, Richaud Y, Rodríguez-Pizà I, Dehay B, Edel M, Bové J, Memo M, Vila M, Raya A, Izpisua Belmonte JC. Sánchez-Danés A, et al. Among authors: bove j. Hum Gene Ther. 2012 Jan;23(1):56-69. doi: 10.1089/hum.2011.054. Epub 2011 Nov 17. Hum Gene Ther. 2012. PMID: 21877920 Free PMC article.
We show that clonal lines of hESC engineered to contain one or two copies of this lentiviral vector retain long-term self-renewing ability and pluripotent differentiation capacity. ...
We show that clonal lines of hESC engineered to contain one or two copies of this lentiviral vector retain long-term self-renewing ab …
Long-term granulocyte transfusion in patients with malignant neoplasms.
Buchholz DH, Blumberg N, Bove JR. Buchholz DH, et al. Among authors: bove jr. Arch Intern Med. 1979 Mar;139(3):317-20. Arch Intern Med. 1979. PMID: 426576
Seventy-four percent of recipients were alive 21 days after completion of transfusions; of the ten deaths, five could be classified as granulocyte transfusion failures. This study suggests that long-term granulocyte transfusion may be required in infected recipients when a …
Seventy-four percent of recipients were alive 21 days after completion of transfusions; of the ten deaths, five could be classified as granu …