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Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study.
Campbell GA, Patrie JT, Gaylinn BD, Thorner MO, Bolton WK. Campbell GA, et al. Among authors: bolton wk. Nephrol Dial Transplant. 2018 Mar 1;33(3):523-530. doi: 10.1093/ndt/gfw474. Nephrol Dial Transplant. 2018. PMID: 28340044 Free PMC article. Clinical Trial.
CONCLUSIONS: MK-0677 increased serum IGF-1 levels with minimal adverse effects in hemodialysis subjects. Studies are needed to evaluate whether long-term therapy with MK-0677 improves PEW, lean body mass, physical strength, quality of life and survival in CKD/ESRD patients …
CONCLUSIONS: MK-0677 increased serum IGF-1 levels with minimal adverse effects in hemodialysis subjects. Studies are needed to evaluate whet …
Pimagedine: a novel therapy for diabetic nephropathy.
Abdel-Rahman E, Bolton WK. Abdel-Rahman E, et al. Among authors: bolton wk. Expert Opin Investig Drugs. 2002 Apr;11(4):565-74. doi: 10.1517/13543784.11.4.565. Expert Opin Investig Drugs. 2002. PMID: 11922864 Review.
Hyperglycaemia is directly involved in causing long-term diabetic complications. The non-enzymatic glycation of proteins, yielding irreversible advanced glycation end products and advanced glycation end products-derived protein crosslinking, participates in the development …
Hyperglycaemia is directly involved in causing long-term diabetic complications. The non-enzymatic glycation of proteins, yielding ir …
Methylprednisolone therapy for acute crescentic rapidly progressive glomerulonephritis.
Bolton WK, Sturgill BC. Bolton WK, et al. Am J Nephrol. 1989;9(5):368-75. doi: 10.1159/000167998. Am J Nephrol. 1989. PMID: 2801784
Twenty-one percent of responding patients lost function at 19.8 months. The long-term response for non-anti-GBM patients was 62%. Patients with low chronicity on biopsy had shorter duration of disease (p = 0.006) and 92% initial, 85% long-term improvement; those wit …
Twenty-one percent of responding patients lost function at 19.8 months. The long-term response for non-anti-GBM patients was 62%. Pat …