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Autophagy prevents graft failure during murine graft-versus-host disease.
Lineburg KE, Leveque-El Mouttie L, Hunter CR, Le Texier L, McGirr C, Teal B, Blazar BR, Lane SW, Hill GR, Lévesque JP, MacDonald KPA. Lineburg KE, et al. Among authors: blazar br. Blood Adv. 2024 Apr 23;8(8):2032-2043. doi: 10.1182/bloodadvances.2023010972. Blood Adv. 2024. PMID: 38295282
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic stem cells (HSC). We investigated the contribution of autophagy to HSC fitness during allogeneic transplantation and graft-versus-host disease …
Autophagy is an intracellular survival process that has established roles in the long-term survival and function of hematopoietic ste …
Notch signaling drives intestinal graft-versus-host disease in mice and nonhuman primates.
Tkachev V, Vanderbeck A, Perkey E, Furlan SN, McGuckin C, Gómez Atria D, Gerdemann U, Rui X, Lane J, Hunt DJ, Zheng H, Colonna L, Hoffman M, Yu A, Outen R, Kelly S, Allman A, Koch U, Radtke F, Ludewig B, Burbach B, Shimizu Y, Panoskaltsis-Mortari A, Chen G, Carpenter SM, Harari O, Kuhnert F, Thurston G, Blazar BR, Kean LS, Maillard I. Tkachev V, et al. Among authors: blazar br. Sci Transl Med. 2023 Jun 28;15(702):eadd1175. doi: 10.1126/scitranslmed.add1175. Epub 2023 Jun 28. Sci Transl Med. 2023. PMID: 37379368
To assess whether Notch's effects are evolutionarily conserved and to identify the mechanisms of Notch signaling inhibition, we studied antibody-mediated DLL4 blockade in a nonhuman primate (NHP) model similar to human allo-HCT. Short-term DLL4 blockade improved posttransp …
To assess whether Notch's effects are evolutionarily conserved and to identify the mechanisms of Notch signaling inhibition, we studied anti …
Antibody based conditioning for allogeneic hematopoietic stem cell transplantation.
Saha A, Blazar BR. Saha A, et al. Among authors: blazar br. Front Immunol. 2022 Oct 20;13:1031334. doi: 10.3389/fimmu.2022.1031334. eCollection 2022. Front Immunol. 2022. PMID: 36341432 Free PMC article. Review.
However, these procedures also result in nonspecific tissue injury that can cause short- and long-term adverse effects as well as incite and amplify graft-versus-host-disease (GVHD). ...
However, these procedures also result in nonspecific tissue injury that can cause short- and long-term adverse effects as well as inc …
Targeting the Retinoid X Receptor Pathway Prevents and Ameliorates Murine Chronic Graft-Versus-Host Disease.
Thangavelu G, Zaiken MC, Mohamed FA, Flynn R, Du J, Rhee SY, Riddle MJ, Aguilar EG, Panoskaltsis-Mortari A, Sanders ME, Blazar BR. Thangavelu G, et al. Among authors: blazar br. Front Immunol. 2022 Mar 11;13:765319. doi: 10.3389/fimmu.2022.765319. eCollection 2022. Front Immunol. 2022. PMID: 35359939 Free PMC article.
Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%-70% incidence of chronic graft-versus-host disease (cGVHD), a major cause of mortality and morbidity in long-term survivors. While systemi …
Most allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients receive peripheral blood stem cell grafts resulting in a 30%-70% i …
Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.
Ludwig LM, Hawley KM, Banks DB, Thomas-Toth AT, Blazar BR, McNerney ME, Leverson JD, LaBelle JL. Ludwig LM, et al. Among authors: blazar br. Cell Death Dis. 2021 Oct 27;12(11):1005. doi: 10.1038/s41419-021-04285-4. Cell Death Dis. 2021. PMID: 34707089 Free PMC article.
Here we focus on the BCL-2 specific inhibitor venetoclax (ABT-199) and its effects following short-term and long-term BCL-2 blockade on T cell subsets. Seven day "short-term" ex vivo and in vivo BCL-2 inhibition led to divergent cell death sensitivity pattern …
Here we focus on the BCL-2 specific inhibitor venetoclax (ABT-199) and its effects following short-term and long-term BCL-2 bl …
Emerging approaches to improve allogeneic hematopoietic cell transplantation outcomes for nonmalignant diseases.
DeFilipp Z, Hefazi M, Chen YB, Blazar BR. DeFilipp Z, et al. Among authors: blazar br. Blood. 2022 Jun 23;139(25):3583-3593. doi: 10.1182/blood.2020009014. Blood. 2022. PMID: 34614174 Free PMC article. Review.
Unique features that distinguish the use of allogeneic HCT in this population include higher rates of graft failure, immune-mediated cytopenias, and the potential to achieve long-term disease-free survival in a mixed chimerism state. Additionally, in contrast to patients w …
Unique features that distinguish the use of allogeneic HCT in this population include higher rates of graft failure, immune-mediated cytopen …
An irradiated marrow niche reveals a small noncollagenous protein mediator of homing, dermatopontin.
Kramer AC, Astuti Y, Elfstrum A, Lehrke MJ, Tolar J, Blazar BR, Blake AL, Taisto ME, Furcich JW, Nolan EE, Durose WW, Webber BR, Geisness A, Wood DK, Lund TC. Kramer AC, et al. Among authors: blazar br. Blood Adv. 2021 Sep 28;5(18):3609-3622. doi: 10.1182/bloodadvances.2021004475. Blood Adv. 2021. PMID: 34448828 Free PMC article.
Interestingly, we found that coincubation of zebrafish or murine hematopoietic cells with recombinant DPT impedes hematopoietic stem and progenitor cell homing by 50% and 86%, respectively. Similarly, this translated into a 24% reduction in long-term engraftment (vs contro …
Interestingly, we found that coincubation of zebrafish or murine hematopoietic cells with recombinant DPT impedes hematopoietic stem and pro …
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2020 Highly morbid forms report.
Wolff D, Radojcic V, Lafyatis R, Cinar R, Rosenstein RK, Cowen EW, Cheng GS, Sheshadri A, Bergeron A, Williams KM, Todd JL, Teshima T, Cuvelier GDE, Holler E, McCurdy SR, Jenq RR, Hanash AM, Jacobsohn D, Santomasso BD, Jain S, Ogawa Y, Steven P, Luo ZK, Dietrich-Ntoukas T, Saban D, Bilic E, Penack O, Griffith LM, Cowden M, Martin PJ, Greinix HT, Sarantopoulos S, Socie G, Blazar BR, Pidala J, Kitko CL, Couriel DR, Cutler C, Schultz KR, Pavletic SZ, Lee SJ, Paczesny S. Wolff D, et al. Among authors: blazar br. Transplant Cell Ther. 2021 Oct;27(10):817-835. doi: 10.1016/j.jtct.2021.06.001. Epub 2021 Jun 10. Transplant Cell Ther. 2021. PMID: 34217703 Free PMC article.
The working group made the following recommendations: (1) Phenotype chronic GVHD clinically and biologically in future cohorts, to describe the incidence, prognostic factors, mechanisms of organ damage, and clinical evolution of highly morbid conditions including long-term …
The working group made the following recommendations: (1) Phenotype chronic GVHD clinically and biologically in future cohorts, to describe …
Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol.
MacDonald KN, Ivison S, Hippen KL, Hoeppli RE, Hall M, Zheng G, Dijke IE, Aklabi MA, Freed DH, Rebeyka I, Gandhi S, West LJ, Piret JM, Blazar BR, Levings MK. MacDonald KN, et al. Among authors: blazar br. Cytotherapy. 2019 Dec;21(12):1216-1233. doi: 10.1016/j.jcyt.2019.10.011. Epub 2019 Dec 3. Cytotherapy. 2019. PMID: 31810768 Free PMC article.
The ability to cryopreserve expanded Tregs will have broad-ranging applications including enabling centralized manufacturing and long-term storage of cell products....
The ability to cryopreserve expanded Tregs will have broad-ranging applications including enabling centralized manufacturing and long-ter …
Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease.
Chung J, Radojcic V, Perkey E, Parnell TJ, Niknafs Y, Jin X, Friedman A, Labrecque N, Blazar BR, Brennan TV, Siebel CW, Maillard I. Chung J, et al. Among authors: blazar br. J Immunol. 2019 Jul 15;203(2):557-568. doi: 10.4049/jimmunol.1900192. Epub 2019 Jun 10. J Immunol. 2019. PMID: 31182480 Free PMC article.
Notch signals delivered during the first 48 h after transplantation drive proinflammatory cytokine production in conventional T cells (Tconv) and inhibit the expansion of regulatory T cells (Tregs). Short-term Notch inhibition induces long-term GVHD protection. Howe …
Notch signals delivered during the first 48 h after transplantation drive proinflammatory cytokine production in conventional T cells (Tconv …
77 results