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Term neonate born with right upper extremity skin necrosis at Birth: A Case Report.
Siddappa AM, Shaik L, Slusher T, Gayken J, Bjorklund A. Siddappa AM, et al. Among authors: bjorklund a. J Burn Care Res. 2024 Feb 6:irae017. doi: 10.1093/jbcr/irae017. Online ahead of print. J Burn Care Res. 2024. PMID: 38320324
The case report is followed by a literature review and discussion of previously published reports of neonatal skin necrosis. A term female neonate was admitted to our hospital at 24 hours of age for skin necrosis of right forearm with sloughing and edema below the right el …
The case report is followed by a literature review and discussion of previously published reports of neonatal skin necrosis. A term f …
Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients.
Sarén T, Ramachandran M, Gammelgård G, Lövgren T, Mirabello C, Björklund ÅK, Wikström K, Hashemi J, Freyhult E, Ahlström H, Amini RM, Hagberg H, Loskog A, Enblad G, Essand M. Sarén T, et al. Among authors: bjorklund ak. Clin Cancer Res. 2023 Oct 13;29(20):4139-4152. doi: 10.1158/1078-0432.CCR-23-0178. Clin Cancer Res. 2023. PMID: 37540566 Free PMC article.
PURPOSE: Although CD19 chimeric antigen receptor T cells (CAR-T) therapy has shown remarkable success in B-cell malignancies, a substantial fraction of patients do not obtain a long-term clinical response. This could be influenced by the quality of the individual CAR-T inf …
PURPOSE: Although CD19 chimeric antigen receptor T cells (CAR-T) therapy has shown remarkable success in B-cell malignancies, a substantial …
Impact of a multifaceted early mobility intervention for critically ill children - the PICU Up! trial: study protocol for a multicenter stepped-wedge cluster randomized controlled trial.
Azamfirei R, Mennie C, Dinglas VD, Fatima A, Colantuoni E, Gurses AP, Balas MC, Needham DM, Kudchadkar SR; on behalf of the PICU Up! Investigators. Azamfirei R, et al. Trials. 2023 Mar 15;24(1):191. doi: 10.1186/s13063-023-07206-2. Trials. 2023. PMID: 36918956 Free PMC article.
This study will provide new and important evidence on ways to optimize short and long-term outcomes for pediatric patients. TRIAL REGISTRATION: ClinicalTrials.gov NCT04989790. ...
This study will provide new and important evidence on ways to optimize short and long-term outcomes for pediatric patients. TRIAL REG …
Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids.
Zhao C, Biondic S, Vandal K, Björklund ÅK, Hagemann-Jensen M, Sommer TM, Canizo J, Clark S, Raymond P, Zenklusen DR, Rivron N, Reik W, Petropoulos S. Zhao C, et al. Among authors: bjorklund ak. Genome Res. 2022 Aug 10;32(9):1627-41. doi: 10.1101/gr.276665.122. Online ahead of print. Genome Res. 2022. PMID: 35948369 Free PMC article.
This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly leading to suboptimal development and longer-term health outcomes....
This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly le …
RNAi prodrugs decrease elevated mRNA levels of Polo-like kinase 1 in ex vivo cultured primary cells from pediatric acute myeloid leukemia patients.
Kolosenko I, Goroshchuk O, Vidarsdottir L, Björklund AC, Dowdy SF, Palm-Apergi C. Kolosenko I, et al. Among authors: bjorklund ac. FASEB J. 2021 May;35(5):e21476. doi: 10.1096/fj.202002454RR. FASEB J. 2021. PMID: 33788972
Pediatric AML patients have a poor prognosis and survivors suffer from long-term side effects. As adult AML cells have an elevated expression of Plk1, AML is a disease candidate for Plk1 inhibition. ...
Pediatric AML patients have a poor prognosis and survivors suffer from long-term side effects. As adult AML cells have an elevated ex …
Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson's Disease.
Shrigley S, Nilsson F, Mattsson B, Fiorenzano A, Mudannayake J, Bruzelius A, Ottosson DR, Björklund A, Hoban DB, Parmar M. Shrigley S, et al. Among authors: bjorklund a. J Parkinsons Dis. 2021;11(2):515-528. doi: 10.3233/JPD-202366. J Parkinsons Dis. 2021. PMID: 33361611 Free PMC article.
A few studies have investigated transplantation of patient-derived dopaminergic (DA) neurons in preclinical models; however, little is known about the long-term integrity and function of grafts derived from patients with PD. ...
A few studies have investigated transplantation of patient-derived dopaminergic (DA) neurons in preclinical models; however, little is known …
Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD.
Hoban DB, Shrigley S, Mattsson B, Breger LS, Jarl U, Cardoso T, Nelander Wahlestedt J, Luk KC, Björklund A, Parmar M. Hoban DB, et al. Among authors: bjorklund a. Proc Natl Acad Sci U S A. 2020 Jun 30;117(26):15209-15220. doi: 10.1073/pnas.2001305117. Epub 2020 Jun 15. Proc Natl Acad Sci U S A. 2020. PMID: 32541058 Free PMC article.
This model gives rise to DA neuron dysfunction and progressive loss of DA neurons from the SN and terminals in the striatum, accompanied by extensive alpha-syn pathology and a prominent inflammatory response, making it an interesting and relevant model in which to examine long- …
This model gives rise to DA neuron dysfunction and progressive loss of DA neurons from the SN and terminals in the striatum, accompanied by …
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson's Disease.
Adler AF, Cardoso T, Nolbrant S, Mattsson B, Hoban DB, Jarl U, Wahlestedt JN, Grealish S, Björklund A, Parmar M. Adler AF, et al. Among authors: bjorklund a. Cell Rep. 2019 Sep 24;28(13):3462-3473.e5. doi: 10.1016/j.celrep.2019.08.058. Cell Rep. 2019. PMID: 31553914 Free PMC article.
Furthermore, we provide evidence that hESC-derived dopaminergic grafts transplanted in a long-term preclinical rat model of Parkinson's disease (PD) receive synaptic input from subtypes of host cortical, striatal, and pallidal neurons that are known to regulate the functio …
Furthermore, we provide evidence that hESC-derived dopaminergic grafts transplanted in a long-term preclinical rat model of Parkinson …
The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective.
Carta M, Björklund A. Carta M, et al. Among authors: bjorklund a. J Neural Transm (Vienna). 2018 Aug;125(8):1195-1202. doi: 10.1007/s00702-018-1865-5. Epub 2018 Feb 26. J Neural Transm (Vienna). 2018. PMID: 29480391 Review.
Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therap …
Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of t …
BDNF over-expression induces striatal serotonin fiber sprouting and increases the susceptibility to l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.
Tronci E, Napolitano F, Muñoz A, Fidalgo C, Rossi F, Björklund A, Usiello A, Carta M. Tronci E, et al. Among authors: bjorklund a. Exp Neurol. 2017 Nov;297:73-81. doi: 10.1016/j.expneurol.2017.07.017. Epub 2017 Jul 27. Exp Neurol. 2017. PMID: 28757258
In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and synaptic plasticity, events strongly implicated in the appearance of l-DOPA-induced dyskinesia (LID), a motor complication occurring in parkin …
In addition to its role in neuronal survival, the brain neurotrophic factor (BDNF) has been shown to influence serotonin transmission and sy …
69 results