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International Consensus Criteria for Pediatric Sepsis and Septic Shock.
Schlapbach LJ, Watson RS, Sorce LR, Argent AC, Menon K, Hall MW, Akech S, Albers DJ, Alpern ER, Balamuth F, Bembea M, Biban P, Carrol ED, Chiotos K, Chisti MJ, DeWitt PE, Evans I, Flauzino de Oliveira C, Horvat CM, Inwald D, Ishimine P, Jaramillo-Bustamante JC, Levin M, Lodha R, Martin B, Nadel S, Nakagawa S, Peters MJ, Randolph AG, Ranjit S, Rebull MN, Russell S, Scott HF, de Souza DC, Tissieres P, Weiss SL, Wiens MO, Wynn JL, Kissoon N, Zimmerman JJ, Sanchez-Pinto LN, Bennett TD; Society of Critical Care Medicine Pediatric Sepsis Definition Task Force. Schlapbach LJ, et al. Among authors: balamuth f. JAMA. 2024 Feb 27;331(8):665-674. doi: 10.1001/jama.2024.0179. JAMA. 2024. PMID: 38245889
FINDINGS: Based on survey data, most pediatric clinicians used sepsis to refer to infection with life-threatening organ dysfunction, which differed from prior pediatric sepsis criteria that used systemic inflammatory response syndrome (SIRS) criteria, which have poor predictive p …
FINDINGS: Based on survey data, most pediatric clinicians used sepsis to refer to infection with life-threatening organ dysfunction, which d …
Multisystem Inflammatory Syndrome in Children: Examining Emerging Data and Identifying Key Knowledge Gaps.
Sartori LF, Balamuth F. Sartori LF, et al. Among authors: balamuth f. Pediatr Emerg Care. 2022 Feb 1;38(2):83-91. doi: 10.1097/PEC.0000000000002633. Pediatr Emerg Care. 2022. PMID: 35100745 Free PMC article.
However, high-level evidence regarding best practices for treatment and long-term outcomes in MIS-C is limited....
However, high-level evidence regarding best practices for treatment and long-term outcomes in MIS-C is limited....
Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations.
Diorio C, McNerney KO, Lambert M, Paessler M, Anderson EM, Henrickson SE, Chase J, Liebling EJ, Burudpakdee C, Lee JH, Balamuth FB, Blatz AM, Chiotos K, Fitzgerald JC, Giglia TM, Gollomp K, Odom John AR, Jasen C, Leng T, Petrosa W, Vella LA, Witmer C, Sullivan KE, Laskin BL, Hensley SE, Bassiri H, Behrens EM, Teachey DT. Diorio C, et al. Among authors: balamuth fb. Blood Adv. 2020 Dec 8;4(23):6051-6063. doi: 10.1182/bloodadvances.2020003471. Blood Adv. 2020. PMID: 33290544 Free PMC article.
Future studies are needed to determine if hospitalized children with SARS-CoV-2 should be screened for TMA, if TMA-directed management is helpful, and if there are any short- or long-term clinical consequences of complement activation and endothelial damage in children wit …
Future studies are needed to determine if hospitalized children with SARS-CoV-2 should be screened for TMA, if TMA-directed management is he …
Factors Associated with Adverse Outcomes among Febrile Young Infants with Invasive Bacterial Infections.
Pruitt CM, Neuman MI, Shah SS, Shabanova V, Woll C, Wang ME, Alpern ER, Williams DJ, Sartori L, Desai S, Leazer RC, Marble RD, McCulloh RJ, DePorre AG, Rooholamini SN, Lumb CE, Balamuth F, Shin S, Aronson PL; Febrile Young Infant Research Collaborative. Pruitt CM, et al. Among authors: balamuth f. J Pediatr. 2019 Jan;204:177-182.e1. doi: 10.1016/j.jpeds.2018.08.066. Epub 2018 Oct 5. J Pediatr. 2019. PMID: 30297292 Free PMC article.

On adjusted analysis, bacterial meningitis (aOR 16.3, 95% CI 6.5-41.0; P < .001), prematurity (aOR 7.1, 95% CI 2.6-19.7; P < .001), and ill appearance (aOR 3.8, 95% CI 1.6-9.1; P = .002) were associated with adverse outcomes. Among infants who were born at term, not

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On adjusted analysis, bacterial meningitis (aOR 16.3, 95% CI 6.5-41.0; P < .001), prematurity (aOR 7.1, 95% CI 2.6-19.7; P < .001), an

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Association of Delayed Antimicrobial Therapy with One-Year Mortality in Pediatric Sepsis.
Han M, Fitzgerald JC, Balamuth F, Keele L, Alpern ER, Lavelle J, Chilutti M, Grundmeier RW, Nadkarni VM, Thomas NJ, Weiss SL. Han M, et al. Among authors: balamuth f. Shock. 2017 Jul;48(1):29-35. doi: 10.1097/SHK.0000000000000833. Shock. 2017. PMID: 28114166 Free PMC article.
OBJECTIVE: Delayed antimicrobial therapy in sepsis is associated with increased hospital mortality, but the impact of antimicrobial timing on long-term outcomes is unknown. We tested the hypothesis that hourly delays to antimicrobial therapy are associated with 1-year mort …
OBJECTIVE: Delayed antimicrobial therapy in sepsis is associated with increased hospital mortality, but the impact of antimicrobial timing o …