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Caloric Restriction Improves Spatial Learning Deficits in Tau Mice.
Cogut V, McNeely TL, Bussian TJ, Graves SI, Baker DJ. Cogut V, et al. Among authors: baker dj. J Alzheimers Dis. 2024;98(3):925-940. doi: 10.3233/JAD-231117. J Alzheimers Dis. 2024. PMID: 38517786
While its effects on amyloid pathology in Alzheimer's disease (AD) mouse models are well-documented, its effects on tauopathy, another hallmark of AD, are less explored. OBJECTIVE: To assess the impact of a short-term 30% CR regimen on age-dependent spatial learning defici …
While its effects on amyloid pathology in Alzheimer's disease (AD) mouse models are well-documented, its effects on tauopathy, another hallm …
Senescence Targeting Methods Impact Alzheimer's Disease Features in 3xTg Mice.
Ng PY, Zhang C, Li H, Baker DJ. Ng PY, et al. Among authors: baker dj. J Alzheimers Dis. 2024;97(4):1751-1763. doi: 10.3233/JAD-230465. J Alzheimers Dis. 2024. PMID: 38306030 Free PMC article.
Using RNA sequencing, we found evidence that synaptic dysfunction and neuroinflammation were attenuated with treatment. These beneficial effects were not observed with short-term senolytic treatment in mice with more advanced disease. CONCLUSIONS: Overall, our results furt …
Using RNA sequencing, we found evidence that synaptic dysfunction and neuroinflammation were attenuated with treatment. These beneficial eff …
An untapped window of opportunity for glioma: targeting therapy-induced senescence prior to recurrence.
Riviere-Cazaux C, Carlstrom LP, Neth BJ, Olson IE, Rajani K, Rahman M, Ikram S, Mansour MA, Mukherjee B, Warrington AE, Short SC, von Zglinicki T, Brown DA, Burma S, Tchkonia T, Schafer MJ, Baker DJ, Kizilbash SH, Kirkland JL, Burns TC. Riviere-Cazaux C, et al. Among authors: baker dj. NPJ Precis Oncol. 2023 Nov 29;7(1):126. doi: 10.1038/s41698-023-00476-8. NPJ Precis Oncol. 2023. PMID: 38030881 Free PMC article. Review.
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven durable salvage therapies for patients that have failed conventional treatments. ...We also discuss how senescent cell clearance can decrease …
High-grade gliomas are primary brain tumors that are incredibly refractory long-term to surgery and chemoradiation, with no proven du …
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning.
Nickbakhsh S, Hughes J, Christofidis N, Griffiths E, Shaaban S, Enright J, Smollett K, Nomikou K, Palmalux N, Tong L, Carmichael S, Sreenu VB, Orton R, Goldstein EJ, Tomb RM; COVID-19 Genomics UK (COG-UK) Consortium; Templeton K, Gunson RN, da Silva Filipe A, Milosevic C, Thomson E, Robertson DL, Holden MTG, Illingworth CJR, Smith-Palmer A. Nickbakhsh S, et al. Sci Rep. 2022 Jul 19;12(1):11735. doi: 10.1038/s41598-022-15661-1. Sci Rep. 2022. PMID: 35853960 Free PMC article.
One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. ...The impact of student infections on the local …
One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of …
Behavioural and neurochemical mechanisms underpinning the feeding-suppressive effect of GLP-1/CCK combinatorial therapy.
Roth E, Benoit S, Quentin B, Lam B, Will S, Ma M, Heeley N, Darwish T, Shrestha Y, Gribble F, Reimann F, Pshenichnaya I, Yeo G, Baker DJ, Trevaskis JL, Blouet C. Roth E, et al. Among authors: baker dj. Mol Metab. 2021 Jan;43:101118. doi: 10.1016/j.molmet.2020.101118. Epub 2020 Nov 19. Mol Metab. 2021. PMID: 33221554 Free PMC article.
The goal of this study was to identify the brain sites and neuronal populations engaged during the co-administration of GLP-1R and CCK1R agonists, an efficient combination therapy in obese rodents. METHODS: We measured acute and long-term feeding and body weight responses …
The goal of this study was to identify the brain sites and neuronal populations engaged during the co-administration of GLP-1R and CCK1R ago …
Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL.
Zhang Y, Gundelach J, Lindquist LD, Baker DJ, van Deursen J, Bram RJ. Zhang Y, et al. Among authors: baker dj. PLoS One. 2019 Oct 29;14(10):e0224172. doi: 10.1371/journal.pone.0224172. eCollection 2019. PLoS One. 2019. PMID: 31661505 Free PMC article.
Unfortunately, they are frequently accompanied by unintended negative impacts, including the induction of cellular senescence and long-term toxicities in normal host tissues. Whether these senescent cells resulting from therapy increase the susceptibility to relapse or sec …
Unfortunately, they are frequently accompanied by unintended negative impacts, including the induction of cellular senescence and long-te …
The power to detect regional declines in common bird populations using continental monitoring data.
Baker DJ, Clarke RH, McGeoch MA. Baker DJ, et al. Ecol Appl. 2019 Jul;29(5):e01918. doi: 10.1002/eap.1918. Epub 2019 Jun 4. Ecol Appl. 2019. PMID: 31162764
Large declines in the abundance of historically common species are now emerging as a major concern. Identifying declining populations through long-term biodiversity monitoring is vital for implementing timely conservation measures. It is, therefore, critical to evaluate th …
Large declines in the abundance of historically common species are now emerging as a major concern. Identifying declining populations throug …
Conserving the abundance of nonthreatened species.
Baker DJ, Garnett ST, O'Connor J, Ehmke G, Clarke RH, Woinarski JCZ, McGeoch MA. Baker DJ, et al. Conserv Biol. 2019 Apr;33(2):319-328. doi: 10.1111/cobi.13197. Epub 2018 Oct 24. Conserv Biol. 2019. PMID: 30047186
Although most conservation effort is directed at species threatened with extinction in the very near term, the value of retaining abundance regardless of global extinction risk is justifiable based on many biodiversity or ecosystem service metrics, including cultural servi …
Although most conservation effort is directed at species threatened with extinction in the very near term, the value of retaining abu …
Gut check on diabesity: leveraging gut mechanisms for the treatment of type 2 diabetes and obesity.
Will S, Hornigold DC, Baker DJ, Coghlan MP, Mesquita M, Trevaskis JL, Naylor J. Will S, et al. Among authors: baker dj. Curr Opin Pharmacol. 2017 Dec;37:10-15. doi: 10.1016/j.coph.2017.07.010. Epub 2017 Aug 10. Curr Opin Pharmacol. 2017. PMID: 28802873 Review.
Subsequent weight loss is accrued over weeks to months but is sustained into the long term. Hence, there exists great enthusiasm to recapitulate these changes in gut hormones in the form of novel combination drugs for type 2 diabetes and obesity....
Subsequent weight loss is accrued over weeks to months but is sustained into the long term. Hence, there exists great enthusiasm to r …
16 results