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Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.
de Baar MP, de Rooij ER, Smolders KG, van Schijndel HB, Timmermans EC, Bethell R. de Baar MP, et al. Antiviral Res. 2007 Oct;76(1):68-74. doi: 10.1016/j.antiviral.2007.05.004. Epub 2007 Jun 21. Antiviral Res. 2007. PMID: 17628710
These results suggest that apricitabine shows a favorable mitochondrial toxicity profile, which is important for long-term clinical use. Further studies are warranted to define the clinical implications of these findings....
These results suggest that apricitabine shows a favorable mitochondrial toxicity profile, which is important for long-term clinical u …
Mitochondrial DNA depletion in HIV-infected patients is more pronounced with chronic hepatitis C and enhanced following treatment with pegylated interferon plus ribavirin.
de Mendoza C, Sánchez-Conde M, Timmermans E, Buitelaar M, de Baar MP, Gonzalez-Lahoz J, Soriano V. de Mendoza C, et al. Among authors: de baar mp. Antivir Ther. 2005;10(4):557-61. Antivir Ther. 2005. PMID: 16038482
BACKGROUND: Mitochondrial DNA (mtDNA) damage seems to be responsible for many of the toxicities associated with the long-term use of nucleoside analogues in HIV-infected patients. These adverse effects, mainly lipoatrophy, seem to be even more pronounced in subjects with h …
BACKGROUND: Mitochondrial DNA (mtDNA) damage seems to be responsible for many of the toxicities associated with the long-term use of …