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Effects of apricitabine and other nucleoside reverse transcriptase inhibitors on replication of mitochondrial DNA in HepG2 cells.
Antiviral Res. 2007 Oct;76(1):68-74. doi: 10.1016/j.antiviral.2007.05.004. Epub 2007 Jun 21.
Antiviral Res. 2007.
PMID: 17628710
These results suggest that apricitabine shows a favorable mitochondrial toxicity profile, which is important for long-term clinical use. Further studies are warranted to define the clinical implications of these findings....
These results suggest that apricitabine shows a favorable mitochondrial toxicity profile, which is important for long-term clinical u …
Mitochondrial DNA depletion in HIV-infected patients is more pronounced with chronic hepatitis C and enhanced following treatment with pegylated interferon plus ribavirin.
de Mendoza C, Sánchez-Conde M, Timmermans E, Buitelaar M, de Baar MP, Gonzalez-Lahoz J, Soriano V.
de Mendoza C, et al. Among authors: de baar mp.
Antivir Ther. 2005;10(4):557-61.
Antivir Ther. 2005.
PMID: 16038482
BACKGROUND: Mitochondrial DNA (mtDNA) damage seems to be responsible for many of the toxicities associated with the long-term use of nucleoside analogues in HIV-infected patients. These adverse effects, mainly lipoatrophy, seem to be even more pronounced in subjects with h …
BACKGROUND: Mitochondrial DNA (mtDNA) damage seems to be responsible for many of the toxicities associated with the long-term use of …
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