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The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer.
Garsed DW, Pandey A, Fereday S, Kennedy CJ, Takahashi K, Alsop K, Hamilton PT, Hendley J, Chiew YE, Traficante N, Provan P, Ariyaratne D, Au-Yeung G, Bateman NW, Bowes L, Brand A, Christie EL, Cunningham JM, Friedlander M, Grout B, Harnett P, Hung J, McCauley B, McNally O, Piskorz AM, Saner FAM, Vierkant RA, Wang C, Winham SJ, Pharoah PDP, Brenton JD, Conrads TP, Maxwell GL, Ramus SJ, Pearce CL, Pike MC, Nelson BH, Goode EL, DeFazio A, Bowtell DDL. Garsed DW, et al. Nat Genet. 2022 Dec;54(12):1853-1864. doi: 10.1038/s41588-022-01230-9. Epub 2022 Dec 1. Nat Genet. 2022. PMID: 36456881 Free PMC article.
We analyzed 60 patients with advanced-stage HGSC who survived more than 10 years after diagnosis using whole-genome sequencing, transcriptome and methylome profiling of their primary tumor samples, comparing this data to 66 short- or moderate-term survivors. Tumors of long …
We analyzed 60 patients with advanced-stage HGSC who survived more than 10 years after diagnosis using whole-genome sequencing, transcriptom …
FDG PET/CT for tumoral and systemic immune response monitoring of advanced melanoma during first-line combination ipilimumab and nivolumab treatment.
Iravani A, Osman MM, Weppler AM, Wallace R, Galligan A, Lasocki A, Hunter MO, Akhurst T, Hofman MS, Lau PKH, Kee D, Au-Yeung G, Sandhu S, Hicks RJ. Iravani A, et al. Eur J Nucl Med Mol Imaging. 2020 Nov;47(12):2776-2786. doi: 10.1007/s00259-020-04815-w. Epub 2020 Apr 21. Eur J Nucl Med Mol Imaging. 2020. PMID: 32338306
CONCLUSION: FDG-PET/CT response evaluation predicts the long-term outcome of patients treated with first-line combination-ICIs. Long-term treatment response monitoring for detection of extracranial secondary progression is feasible by FDG-PET/CT. ...
CONCLUSION: FDG-PET/CT response evaluation predicts the long-term outcome of patients treated with first-line combination-ICIs. Long- …
A closer look at immune-mediated myocarditis in the era of combined checkpoint blockade and targeted therapies.
Guo CW, Alexander M, Dib Y, Lau PKH, Weppler AM, Au-Yeung G, Lee B, Khoo C, Mooney D, Joshi SB, Creati L, Sandhu S. Guo CW, et al. Eur J Cancer. 2020 Jan;124:15-24. doi: 10.1016/j.ejca.2019.09.009. Eur J Cancer. 2020. PMID: 31707280
The sixth patient improved with cardiac failure management alone. Three of the four patients responding to ICI derived long-term benefit. Clinical vigilance, prompt multimodal diagnosis and multidisciplinary management are paramount for the treatment of immune-mediated myo …
The sixth patient improved with cardiac failure management alone. Three of the four patients responding to ICI derived long-term bene …
Human embryonic stem cell-derived oligodendrocyte progenitors remyelinate the brain and rescue behavioral deficits following radiation.
Piao J, Major T, Auyeung G, Policarpio E, Menon J, Droms L, Gutin P, Uryu K, Tchieu J, Soulet D, Tabar V. Piao J, et al. Among authors: auyeung g. Cell Stem Cell. 2015 Feb 5;16(2):198-210. doi: 10.1016/j.stem.2015.01.004. Cell Stem Cell. 2015. PMID: 25658373 Free PMC article.
Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is associated with significant and irreversible long-term side effects, including cognitive decline and impairment of motor coordination. ...
Radiation therapy to the brain is a powerful tool in the management of many cancers, but it is associated with significant and irreversible …
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L. Kriks S, et al. Among authors: auyeung g. Nature. 2011 Nov 6;480(7378):547-51. doi: 10.1038/nature10648. Nature. 2011. PMID: 22056989 Free PMC article.
In vivo survival and function is demonstrated in Parkinson's disease models using three host species. Long-term engraftment in 6-hydroxy-dopamine-lesioned mice and rats demonstrates robust survival of midbrain DA neurons derived from human embryonic stem (ES) cells, comple …
In vivo survival and function is demonstrated in Parkinson's disease models using three host species. Long-term engraftment in 6-hydr …