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Calorie restriction reduces biomarkers of cellular senescence in humans.
Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJA, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK. Aversa Z, et al. Among authors: atkinson ej. Aging Cell. 2024 Feb;23(2):e14038. doi: 10.1111/acel.14038. Epub 2023 Nov 14. Aging Cell. 2024. PMID: 37961856 Free PMC article.
Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet …
Using plasma specimens from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) phase 2 study, w …
Distal radius fractures and risk of incident neurocognitive disorders in older adults: a retrospective cohort study.
Baruth JM, Lapid MI, Clarke B, Shin AY, Atkinson EJ, Eberhard J, Zavatta G, Åstrand J. Baruth JM, et al. Among authors: atkinson ej. Osteoporos Int. 2022 Nov;33(11):2307-2314. doi: 10.1007/s00198-022-06497-6. Epub 2022 Jul 15. Osteoporos Int. 2022. PMID: 35835861
This study reports that DRF are also associated with greater risk of developing neurocognitive disorders in older adults. Timely intervention may improve early recognition and long-term outcomes for older adults at risk of cognitive decline....
This study reports that DRF are also associated with greater risk of developing neurocognitive disorders in older adults. Timely interventio …
Fisetin for COVID-19 in skilled nursing facilities: Senolytic trials in the COVID era.
Verdoorn BP, Evans TK, Hanson GJ, Zhu Y, Langhi Prata LGP, Pignolo RJ, Atkinson EJ, Wissler-Gerdes EO, Kuchel GA, Mannick JB, Kritchevsky SB, Khosla S, Rizza SA, Walston JD, Musi N, Lipsitz LA, Kiel DP, Yung R, LeBrasseur NK, Singh RJ, McCarthy T, Puskarich MA, Niedernhofer LJ, Robbins PD, Sorenson M, Tchkonia T, Kirkland JL. Verdoorn BP, et al. Among authors: atkinson ej. J Am Geriatr Soc. 2021 Nov;69(11):3023-3033. doi: 10.1111/jgs.17416. Epub 2021 Aug 20. J Am Geriatr Soc. 2021. PMID: 34375437 Free PMC article.
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, consent procedures, methods for obtaining biospecimens and clinical data, staffing, investigational product administration issues, and potent …
We consider logistic challenges of conducting trials in long-term care settings in the SARS-CoV-2 era, including restricted access, c …
Reproductive history and progressive multiple sclerosis risk in women.
Zeydan B, Atkinson EJ, Weis DM, Smith CY, Gazzuola Rocca L, Rocca WA, Keegan BM, Weinshenker BG, Kantarci K, Kantarci OH. Zeydan B, et al. Among authors: atkinson ej. Brain Commun. 2020 Nov 17;2(2):fcaa185. doi: 10.1093/braincomms/fcaa185. eCollection 2020. Brain Commun. 2020. PMID: 33409489 Free PMC article.

Menarche age was similar between multiple sclerosis and control females (P = 0.306). Females with multiple sclerosis had fewer full-term pregnancies than the controls (P < 0.001). Non-natural menopause was more common in multiple sclerosis (40.7%) than in controls (30.1

…
Menarche age was similar between multiple sclerosis and control females (P = 0.306). Females with multiple sclerosis had fewer full-term …
Relapse recovery: The forgotten variable in multiple sclerosis clinical trials.
Kantarci OH, Zeydan B, Atkinson EJ, Conway BL, Castrillo-Viguera C, Rodriguez M. Kantarci OH, et al. Among authors: atkinson ej. Neurol Neuroimmunol Neuroinflamm. 2019 Dec 17;7(2):e653. doi: 10.1212/NXI.0000000000000653. Print 2020 Mar. Neurol Neuroimmunol Neuroinflamm. 2019. PMID: 31848231 Free PMC article.
OBJECTIVE: To determine whether basing the decision to initiate immediate vs delayed disease-modifying therapy (DMT) on extent of recovery after initial relapse affects long-term disability accumulation in a multiple sclerosis (MS) evidence-based setting. ...HRs for EDSS s …
OBJECTIVE: To determine whether basing the decision to initiate immediate vs delayed disease-modifying therapy (DMT) on extent of recovery a …
External validation of the United Kingdom-primary biliary cholangitis risk scores of patients with primary biliary cholangitis treated with ursodeoxycholic acid.
Cheung AC, Gulamhusein AF, Juran BD, Schlicht EM, McCauley BM, de Andrade M, Atkinson EJ, Lazaridis KN. Cheung AC, et al. Among authors: atkinson ej. Hepatol Commun. 2018 Apr 24;2(6):676-682. doi: 10.1002/hep4.1186. eCollection 2018 Jun. Hepatol Commun. 2018. PMID: 29881819 Free PMC article.
Conclusion: In patients assessed at a North American tertiary medical center, the UK-PBC risk score had excellent discrimination and was reasonably calibrated both in the short and long term. (Hepatology Communications 2018;2:676-682)....
Conclusion: In patients assessed at a North American tertiary medical center, the UK-PBC risk score had excellent discrimination and was rea …
Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis.
Eaton JE, Barr Fritcher EG, Gores GJ, Atkinson EJ, Tabibian JH, Topazian MD, Gossard AA, Halling KC, Kipp BR, Lazaridis KN. Eaton JE, et al. Among authors: atkinson ej. Am J Gastroenterol. 2015 Feb;110(2):299-309. doi: 10.1038/ajg.2014.433. Epub 2015 Jan 27. Am J Gastroenterol. 2015. PMID: 25623660 Free PMC article.
However, a subset of PSC patients with polysomy do not manifest CCA even after long-term follow-up. It is unknown if patients with chromosomal gains detected by FISH in multiple areas of the biliary tree (i.e., multifocal polysomy, MFP) are more likely to be diagnosed with …
However, a subset of PSC patients with polysomy do not manifest CCA even after long-term follow-up. It is unknown if patients with ch …
Predictors of excess mortality after fracture: a population-based cohort study.
Melton LJ 3rd, Atkinson EJ, St Sauver JL, Achenbach SJ, Therneau TM, Rocca WA, Amin S. Melton LJ 3rd, et al. Among authors: atkinson ej. J Bone Miner Res. 2014 Jul;29(7):1681-90. doi: 10.1002/jbmr.2193. J Bone Miner Res. 2014. PMID: 24677169 Free PMC article.
However, the predominant comorbid conditions were mainly those responsible for mortality in the general population, rather than the specific diseases most closely associated with secondary osteoporosis. To reduce long-term deaths in the fracture population as a whole, a mo …
However, the predominant comorbid conditions were mainly those responsible for mortality in the general population, rather than the specific …
Long-term mortality following fractures at different skeletal sites: a population-based cohort study.
Melton LJ 3rd, Achenbach SJ, Atkinson EJ, Therneau TM, Amin S. Melton LJ 3rd, et al. Among authors: atkinson ej. Osteoporos Int. 2013 May;24(5):1689-96. doi: 10.1007/s00198-012-2225-1. Epub 2012 Dec 5. Osteoporos Int. 2013. PMID: 23212281 Free PMC article.
Adjusting for age, sex, and precipitating cause, the relative risk of death was increased following fractures at most skeletal sites. INTRODUCTION: This study aims to determine long-term survival following fractures due to any cause at each skeletal site. ...Adjusting for …
Adjusting for age, sex, and precipitating cause, the relative risk of death was increased following fractures at most skeletal sites. INTROD …
Influence of hysterectomy on long-term fracture risk.
Melton LJ 3rd, Achenbach SJ, Gebhart JB, Babalola EO, Atkinson EJ, Bharucha AE. Melton LJ 3rd, et al. Among authors: atkinson ej. Fertil Steril. 2007 Jul;88(1):156-62. doi: 10.1016/j.fertnstert.2006.11.080. Epub 2007 Jan 30. Fertil Steril. 2007. PMID: 17270180 Free PMC article.
OBJECTIVE: To assess long-term fracture risk after hysterectomy, with or without oophorectomy. ...CONCLUSION(S): Hysterectomy does not appear to pose much long-term risk for fractures, but the association of fractures with surgery for uterine prolapse deserves furth …
OBJECTIVE: To assess long-term fracture risk after hysterectomy, with or without oophorectomy. ...CONCLUSION(S): Hysterectomy does no …
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