Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Filters applied: . Clear all
Page 1
13C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock.
Wolfschmitt EM, Vogt JA, Hogg M, Wachter U, Stadler N, Kapapa T, Datzmann T, Messerer DAC, Hoffmann A, Gröger M, Münz F, Mathieu R, Mayer S, Merz T, Asfar P, Calzia E, Radermacher P, Zink F. Wolfschmitt EM, et al. Among authors: asfar p. Front Immunol. 2024 Jan 9;14:1319986. doi: 10.3389/fimmu.2023.1319986. eCollection 2023. Front Immunol. 2024. PMID: 38332911 Free PMC article.
To uncover the potential impact of increased oxygen fractions on circulating immune cells during intensive care, we have performed a (13)C-metabolic flux analysis (MFA) on PBMCs and granulocytes isolated from two long-term, resuscitated models of combined acute subdural he …
To uncover the potential impact of increased oxygen fractions on circulating immune cells during intensive care, we have performed a (13)C-m …
Long-term immunosuppressive treatment is not associated with worse outcome in patients hospitalized in the intensive care unit for septic shock: the PACIFIC study.
Vaidie J, Peju E, Jandeaux LM, Lesouhaitier M, Lacherade JC, Guillon A, Wittebole X, Asfar P, Evrard B, Daix T, Vignon P, François B. Vaidie J, et al. Among authors: asfar p. Crit Care. 2023 Sep 2;27(1):340. doi: 10.1186/s13054-023-04626-z. Crit Care. 2023. PMID: 37660107 Free PMC article.
Neither in univariate nor in multivariate analysis immunosuppressive therapy was associated with a higher ICU mortality (OR: 0.95; [95% CI 0.56-1.58]: p = 0.86 and 1.13 [95% CI 0.61-2.05]: p = 0.69, respectively) or 3-month mortality (OR: 1.13; [95% CI 0.69-1.82]: p = 0.62 and OR …
Neither in univariate nor in multivariate analysis immunosuppressive therapy was associated with a higher ICU mortality (OR: 0.95; [95% CI 0 …
Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis.
Richards-Belle A, Hylands M, Muttalib F, Taran S, Rochwerg B, Day A, Mouncey PR, Radermacher P, Couban R, Asfar P, Adhikari NKJ, Lamontagne F. Richards-Belle A, et al. Among authors: asfar p. Crit Care Med. 2023 Feb 1;51(2):254-266. doi: 10.1097/CCM.0000000000005736. Epub 2022 Nov 18. Crit Care Med. 2023. PMID: 36398968 Free PMC article.
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- and longer-term mortality, use of life-sustaining therapies, vasopressor-related complications, neurologic outcome, and quality of l …
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- …
The effect of targeted hyperoxemia in a randomized controlled trial employing a long-term resuscitated, model of combined acute subdural hematoma and hemorrhagic shock in swine with coronary artery disease: An exploratory, hypothesis-generating study.
Datzmann T, Messerer DAC, Münz F, Hoffmann A, Gröger M, Mathieu R, Mayer S, Gässler H, Zink F, McCook O, Merz T, Scheuerle A, Wolfschmitt EM, Thebrath T, Zuech S, Calzia E, Asfar P, Radermacher P, Kapapa T. Datzmann T, et al. Among authors: asfar p. Front Med (Lausanne). 2022 Aug 22;9:971882. doi: 10.3389/fmed.2022.971882. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36072939 Free PMC article.
Therefore, this study investigated the impact of targeted hyperoxemia in a long-term, resuscitated model of combined acute subdural hematoma (ASDH)-induced brain injury and HS. ...
Therefore, this study investigated the impact of targeted hyperoxemia in a long-term, resuscitated model of combined acute subdural h …
Menstrual Toxic Shock Syndrome: A French Nationwide Multicenter Retrospective Study.
Contou D, Colin G, Travert B, Jochmans S, Conrad M, Lascarrou JB, Painvin B, Ferré A, Schnell D, La Combe B, Coudroy R, Ehrmann S, Rambaud J, Wiedemann A, Asfar P, Kalfon P, Guérot E, Préau S, Argaud L, Daviet F, Dellamonica J, Dupont A, Fartoukh M, Kamel T, Béduneau G, Canouï-Poitrine F, Boutin E, Lina G, Mekontso Dessap A, Tristan A, de Prost N; French m-TSS Study Group. Contou D, et al. Among authors: asfar p. Clin Infect Dis. 2022 Jan 29;74(2):246-253. doi: 10.1093/cid/ciab378. Clin Infect Dis. 2022. PMID: 33906228
BACKGROUND: Studies describing the clinical features and short-term prognosis of patients admitted to the intensive care unit (ICU) for menstrual toxic shock syndrome (m-TSS) are lacking. ...The aim of the study was to describe the clinical features and short-term p …
BACKGROUND: Studies describing the clinical features and short-term prognosis of patients admitted to the intensive care unit (ICU) f …
Unexpected cardiac arrests occurring inside the ICU: outcomes of a French prospective multicenter study.
Leloup M, Briatte I, Langlois A, Cariou A, Lesieur O; ACIR study group. Leloup M, et al. Intensive Care Med. 2020 May;46(5):1005-1015. doi: 10.1007/s00134-020-05992-w. Epub 2020 Mar 9. Intensive Care Med. 2020. PMID: 32152653
We hypothesize that certain patient characteristics and treatments are associated with survival and long-term functional outcome following in-ICU cardiac arrest. METHODS: Over a 12-month period, cardiac arrests with resuscitation attempts were prospectively investigated in …
We hypothesize that certain patient characteristics and treatments are associated with survival and long-term functional outcome foll …
Early vasopressor use following traumatic injury: a systematic review.
Hylands M, Toma A, Beaudoin N, Frenette AJ, D'Aragon F, Belley-Côté É, Charbonney E, Møller MH, Laake JH, Vandvik PO, Siemieniuk RA, Rochwerg B, Lauzier F, Green RS, Ball I, Scales D, Murthy S, Kwong JSW, Guyatt G, Rizoli S, Asfar P, Lamontagne F. Hylands M, et al. Among authors: asfar p. BMJ Open. 2017 Nov 17;7(11):e017559. doi: 10.1136/bmjopen-2017-017559. BMJ Open. 2017. PMID: 29151048 Free PMC article. Review.
Across observational studies, vasopressor use was associated with increased short-term mortality, with unadjusted risk ratios ranging from 2.31 to 7.39. ...Two clinical trials are currently ongoing. No study measured long-term quality of life or cognitive function. …
Across observational studies, vasopressor use was associated with increased short-term mortality, with unadjusted risk ratios ranging …
Does hyperoxia enhance susceptibility to secondary pulmonary infection in the ICU?
Nußbaum B, Radermacher P, Asfar P, Hartmann C. Nußbaum B, et al. Among authors: asfar p. Crit Care. 2016 Aug 16;20(1):239. doi: 10.1186/s13054-016-1427-x. Crit Care. 2016. PMID: 27526848 Free PMC article.
Consequently, hyperoxia during the peri-operative period has been advocated for surgical patients in order to reduce surgical site infection. However, there is ample evidence that long-term exposure to hyperoxia impaired bacterial phagocytosis and thereby aggravated both b …
Consequently, hyperoxia during the peri-operative period has been advocated for surgical patients in order to reduce surgical site infection …
Mean arterial pressure target in patients with septic shock.
Beloncle F, Radermacher P, Guerin C, Asfar P. Beloncle F, et al. Among authors: asfar p. Minerva Anestesiol. 2016 Jul;82(7):777-84. Epub 2016 Mar 11. Minerva Anestesiol. 2016. PMID: 26967829 Free article.
Moreover, sympathetic over-stimulation due to high doses of vasopressor (needed to achieve high mean arterial pressure targets) may be associated with numerous harmful effects. Observational and small short term interventional studies did not provide a definitive answer to …
Moreover, sympathetic over-stimulation due to high doses of vasopressor (needed to achieve high mean arterial pressure targets) may be assoc …
Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update.
Hafner S, Beloncle F, Koch A, Radermacher P, Asfar P. Hafner S, et al. Among authors: asfar p. Ann Intensive Care. 2015 Dec;5(1):42. doi: 10.1186/s13613-015-0084-6. Epub 2015 Nov 19. Ann Intensive Care. 2015. PMID: 26585328 Free PMC article.
On the other hand, "oxygen toxicity" due to the increased formation of reactive oxygen species limits its use, because it may cause serious deleterious side effects, especially in conditions of ischemia/reperfusion. While these effects are particularly pronounced during long-t …
On the other hand, "oxygen toxicity" due to the increased formation of reactive oxygen species limits its use, because it may cause serious …
26 results