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Ceftriaxone to prevent early ventilator-associated pneumonia in patients with acute brain injury: a multicentre, randomised, double-blind, placebo-controlled, assessor-masked superiority trial.
Dahyot-Fizelier C, Lasocki S, Kerforne T, Perrigault PF, Geeraerts T, Asehnoune K, Cinotti R, Launey Y, Cottenceau V, Laffon M, Gaillard T, Boisson M, Aleyrat C, Frasca D, Mimoz O; PROPHY-VAP Study Group and the ATLANREA Study Group. Dahyot-Fizelier C, et al. Among authors: asehnoune k. Lancet Respir Med. 2024 May;12(5):375-385. doi: 10.1016/S2213-2600(23)00471-X. Epub 2024 Jan 20. Lancet Respir Med. 2024. PMID: 38262428 Clinical Trial.
BACKGROUND: Patients with acute brain injury are at high risk of ventilator-associated pneumonia (VAP). The benefit of short-term antibiotic prophylaxis remains debated. We aimed to establish the effect of an early, single dose of the antibiotic ceftriaxone on the incidenc …
BACKGROUND: Patients with acute brain injury are at high risk of ventilator-associated pneumonia (VAP). The benefit of short-term ant …
Anxiety and depression symptoms in relatives of moderate-to-severe traumatic brain injury survivors - A multicentre cohort.
Cinotti R, Chopin A, Moyer JD, Huet O, Lasocki S, Cohen B, Dahyot-Fizelier C, Chalard K, Seguin P, Martin FP, Lerebourg C, Guitteny M, Chenet A, Perrouin-Verbe B, Asehnoune K, Feuillet F, Sébille V, Roquilly A; Atlanréa Group and the Société Française d’Anesthésie-Réanimation–SFAR Research Network. Cinotti R, et al. Among authors: asehnoune k. Anaesth Crit Care Pain Med. 2023 Oct;42(5):101232. doi: 10.1016/j.accpm.2023.101232. Epub 2023 Apr 11. Anaesth Crit Care Pain Med. 2023. PMID: 37054915 Clinical Trial.
Anxiety and depression were inversely correlated with the patient's mental health status at 6 months. CONCLUSIONS: Long-term follow-up must provide psychological care to relatives after TBI....
Anxiety and depression were inversely correlated with the patient's mental health status at 6 months. CONCLUSIONS: Long-term follow-u …
Long-Term Outcome of Severe Metabolic Acidemia in ICU Patients, a BICAR-ICU Trial Post Hoc Analysis.
Bendiab E, Garnier F, Soler M, Fosset M, Jaber S, Molinari N, Jung B; BICAR-ICU Investigators. Bendiab E, et al. Crit Care Med. 2023 Jan 1;51(1):e1-e12. doi: 10.1097/CCM.0000000000005706. Epub 2022 Nov 8. Crit Care Med. 2023. PMID: 36351174 Clinical Trial.
OBJECTIVES: Long-term prognosis of ICU survivors is a major issue. Severe acidemia upon ICU admission is associated with very high short-term mortality. Since the long-term prognosis of these patients is unknown, we aimed to determine the long-term hea …
OBJECTIVES: Long-term prognosis of ICU survivors is a major issue. Severe acidemia upon ICU admission is associated with very high sh …
Intracranial pressure monitoring in patients with acute brain injury in the intensive care unit (SYNAPSE-ICU): an international, prospective observational cohort study.
Robba C, Graziano F, Rebora P, Elli F, Giussani C, Oddo M, Meyfroidt G, Helbok R, Taccone FS, Prisco L, Vincent JL, Suarez JI, Stocchetti N, Citerio G; SYNAPSE-ICU Investigators. Robba C, et al. Lancet Neurol. 2021 Jul;20(7):548-558. doi: 10.1016/S1474-4422(21)00138-1. Lancet Neurol. 2021. PMID: 34146513 Free article.
The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world and to assess variations in indications for ICP monitoring and interventions, and their association with long-term patient outcomes. ME …
The aims of this study were to describe current ICP monitoring practises for patients with acute brain injury at centres around the world an …
Circulating Regulatory T Cells Expressing Tumor Necrosis Factor Receptor Type 2 Contribute to Sepsis-Induced Immunosuppression in Patients During Septic Shock.
Gaborit BJ, Chaumette T, Chauveau M, Asquier-Khati A, Roquilly A, Boutoille D, Josien R, Salomon BL, Asehnoune K. Gaborit BJ, et al. Among authors: asehnoune k. J Infect Dis. 2021 Dec 15;224(12):2160-2169. doi: 10.1093/infdis/jiab276. J Infect Dis. 2021. PMID: 34019653
BACKGROUND: Septic shock remains a major cause of death that can be complicated by long-term impairment in immune function. Among regulatory T (Treg) cells, the tumor necrosis factor receptor 2 positive (TNFR2pos) Treg-cell subset endorses significant immunosuppressive fun …
BACKGROUND: Septic shock remains a major cause of death that can be complicated by long-term impairment in immune function. Among reg …
Digital ischaemia aetiologies and mid-term follow-up: A cohort study of 323 patients.
Raimbeau A, Pistorius MA, Goueffic Y, Connault J, Plissonneau-Duquene P, Maurel B, Reignier J, Asehnoune K, Artifoni M, Didier Q, Gautier G, Trochu JN, Rozec B, N'Gohou C, Durant C, Pottier P, Denis Le Sève J, Brebion N, Agard C, Espitia O. Raimbeau A, et al. Among authors: asehnoune k. Medicine (Baltimore). 2021 May 21;100(20):e25659. doi: 10.1097/MD.0000000000025659. Medicine (Baltimore). 2021. PMID: 34011027 Free PMC article.
Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study.
Cinotti R, Lascarrou JB, Azais MA, Colin G, Quenot JP, Mahé PJ, Roquilly A, Gaultier A, Asehnoune K, Reignier J. Cinotti R, et al. Among authors: asehnoune k. Crit Care. 2021 Mar 10;25(1):98. doi: 10.1186/s13054-021-03509-5. Crit Care. 2021. PMID: 33691730 Free PMC article. Clinical Trial.
Trial registration NCT02345681, Registered January 26 2015, Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02345681?term=02345681&draw=2&rank=1 ....
Trial registration NCT02345681, Registered January 26 2015, Prospectively registered, https://clinicaltrials.gov/ct2/show/NCT02345681?ter …
Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.
Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, Rooze P, Broquet A, Misme-Aucouturier B, Chaumette T, Vourc'h M, Cinotti R, Marec N, Gauttier V, McWilliam HEG, Altare F, Poschmann J, Villadangos JA, Asehnoune K. Roquilly A, et al. Among authors: asehnoune k. Nat Immunol. 2020 Aug;21(8):962. doi: 10.1038/s41590-020-0739-9. Nat Immunol. 2020. PMID: 32581370
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis.
Roquilly A, Jacqueline C, Davieau M, Mollé A, Sadek A, Fourgeux C, Rooze P, Broquet A, Misme-Aucouturier B, Chaumette T, Vourc'h M, Cinotti R, Marec N, Gauttier V, McWilliam HEG, Altare F, Poschmann J, Villadangos JA, Asehnoune K. Roquilly A, et al. Among authors: asehnoune k. Nat Immunol. 2020 Jun;21(6):636-648. doi: 10.1038/s41590-020-0673-x. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424365
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