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Cortisol awakening response and developmental outcomes at 6-7 years in children born extremely preterm.
Lowe J, Fuller JF, Dempsey AG, Do B, Bann CM, Das A, Gustafson KE, Vohr BR, Hintz SR, Watterberg KL; SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Lowe J, et al. Pediatr Res. 2023 Feb;93(3):689-695. doi: 10.1038/s41390-022-02113-9. Epub 2022 Jun 17. Pediatr Res. 2023. PMID: 35715492 Free PMC article. Clinical Trial.
BACKGROUND: Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. ...RESULTS: Cortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were s …
BACKGROUND: Extremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at s …
Physiologically Based Pharmacokinetic Modeling of Meropenem in Preterm and Term Infants.
Ganguly S, Edginton AN, Gerhart JG, Cohen-Wolkowiez M, Greenberg RG, Gonzalez D; Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee. Ganguly S, et al. Clin Pharmacokinet. 2021 Dec;60(12):1591-1604. doi: 10.1007/s40262-021-01046-6. Epub 2021 Jun 22. Clin Pharmacokinet. 2021. PMID: 34155614 Free PMC article.
We applied physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of meropenem in preterm and term infants. METHODS: An adult meropenem PBPK model was developed in PK-Sim() (Version 8) and scaled to infants accounting for renal transporter on …
We applied physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of meropenem in preterm and term inf …
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH; NEOLEV2 INVESTIGATORS. Sharpe C, et al. Among authors: arnell k. Pediatrics. 2020 Jun;145(6):e20193182. doi: 10.1542/peds.2019-3182. Epub 2020 May 8. Pediatrics. 2020. PMID: 32385134 Free PMC article. Clinical Trial.
Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed....
Higher-dose studies of levetiracetam are warranted, and definitive studies with long-term outcome measures are needed....
Behavioral Deficits at 18-22 Months of Age Are Associated with Early Cerebellar Injury and Cognitive and Language Performance in Children Born Extremely Preterm.
Duncan AF, Bann CM, Dempsey A, Peralta-Carcelen M, Hintz S; Eunice Kennedy Shriver National Institute of Child Health and Development Neonatal Research Network. Duncan AF, et al. J Pediatr. 2019 Jan;204:148-156.e4. doi: 10.1016/j.jpeds.2018.08.059. Epub 2018 Oct 3. J Pediatr. 2019. PMID: 30292492 Free PMC article. Clinical Trial.
We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. Mean BITSEA and Bayley-III scores were compared using ANOVA and positive screen rates with the chi(2) test. ...CONCLUSIONS: Social-emotional …
We examined associations of Problem and Competence scores and positive screen rates with cranial ultrasonography and near-term MRI. M …
Assessing the Feasibility of Providing a Real-Time Response to Seizures Detected With Continuous Long-Term Neonatal Electroencephalography Monitoring.
Sharpe C, Davis SL, Reiner GE, Lee LI, Gold JJ, Nespeca M, Wang SG, Joe P, Kuperman R, Gardner M, Honold J, Lane B, Knodel E, Rowe D, Battin MR, Bridge R, Goodmar J, Castro B, Rasmussen M, Arnell K, Harbert M, Haas R. Sharpe C, et al. Among authors: arnell k. J Clin Neurophysiol. 2019 Jan;36(1):9-13. doi: 10.1097/WNP.0000000000000525. J Clin Neurophysiol. 2019. PMID: 30289769 Free PMC article.
Outcome of Preterm Infants with Transient Cystic Periventricular Leukomalacia on Serial Cranial Imaging Up to Term Equivalent Age.
Sarkar S, Shankaran S, Barks J, Do BT, Laptook AR, Das A, Ambalavanan N, Van Meurs KP, Bell EF, Sanchez PJ, Hintz SR, Wyckoff MH, Stoll BJ, Carlo WA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Sarkar S, et al. J Pediatr. 2018 Apr;195:59-65.e3. doi: 10.1016/j.jpeds.2017.12.010. Epub 2018 Feb 2. J Pediatr. 2018. PMID: 29398046 Free PMC article.
Providing a Placental Transfusion in Newborns Who Need Resuscitation.
Katheria AC, Brown MK, Rich W, Arnell K. Katheria AC, et al. Among authors: arnell k. Front Pediatr. 2017 Jan 25;5:1. doi: 10.3389/fped.2017.00001. eCollection 2017. Front Pediatr. 2017. PMID: 28180126 Free PMC article. Review.
Allowing a placental transfusion to occur by delaying the clamping of the umbilical cord is an extremely effective method of enhancing arterial oxygen content, increasing cardiac output, and improving oxygen delivery. However, premature and term newborns who require resusc …
Allowing a placental transfusion to occur by delaying the clamping of the umbilical cord is an extremely effective method of enhancing arter …
Neuroimaging and neurodevelopmental outcome in extremely preterm infants.
Hintz SR, Barnes PD, Bulas D, Slovis TL, Finer NN, Wrage LA, Das A, Tyson JE, Stevenson DK, Carlo WA, Walsh MC, Laptook AR, Yoder BA, Van Meurs KP, Faix RG, Rich W, Newman NS, Cheng H, Heyne RJ, Vohr BR, Acarregui MJ, Vaucher YE, Pappas A, Peralta-Carcelen M, Wilson-Costello DE, Evans PW, Goldstein RF, Myers GJ, Poindexter BB, McGowan EC, Adams-Chapman I, Fuller J, Higgins RD; SUPPORT Study Group of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Hintz SR, et al. Pediatrics. 2015 Jan;135(1):e32-42. doi: 10.1542/peds.2014-0898. Epub 2014 Dec 1. Pediatrics. 2015. PMID: 25554820 Free PMC article. Clinical Trial.
BACKGROUND: Extremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, but near-term brain MRI has been reported to better predict outcomes. We prospectively evaluated MRI white matter abnormality (WMA) …
BACKGROUND: Extremely preterm infants are at risk for neurodevelopmental impairment (NDI). Early cranial ultrasound (CUS) is usual practice, …
25 results