Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

19 results

Filters applied: . Clear all
Page 1
Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification.
Aakre KM, Apple FS, Mills NL, Meex SJR, Collinson PO; International Federation of Clinical Chemistry Committee on Clinical Applications of Cardiac Biomarkers (IFCC C-CB). Aakre KM, et al. Among authors: apple fs. Clin Chem. 2024 Mar 2;70(3):497-505. doi: 10.1093/clinchem/hvad185. Clin Chem. 2024. PMID: 38102065 Review.
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for long-term risk prediction of cardiovascular disease. Accelerated diagnostic pathways prevent unnecessary hospital admission, but requir …
BACKGROUND: Cardiac troponin measurements are indispensable for the diagnosis of myocardial infarction and provide useful information for lo …
Implementation of a high sensitivity cardiac troponin I assay and risk of myocardial infarction or death at five years: observational analysis of a stepped wedge, cluster randomised controlled trial.
Lee KK, Doudesis D, Ferry AV, Chapman AR, Kimenai DM, Fujisawa T, Bularga A, Lowry MTH, Taggart C, Schulberg S, Wereski R, Tuck C, Strachan FE, Newby DE, Anand A, Shah ASV, Mills NL; High-STEACS Investigators. Lee KK, et al. BMJ. 2023 Nov 27;383:e075009. doi: 10.1136/bmj-2023-075009. BMJ. 2023. PMID: 38011922 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients with suspected acute coronary syndrome. ...
OBJECTIVE: To evaluate the impact of implementing a high sensitivity assay for cardiac troponin I on long term outcomes in patients w …
Single Troponin Measurement to Rule Out Myocardial Infarction: JACC Review Topic of the Week.
Jaffe AS, Body R, Mills NL, Aakre KM, Collinson PO, Saenger A, Hammarsten O, Wereski R, Omland T, Sandoval Y, Ordonez-Llanos J, Apple FS; IFCC Committee on Cardiac Bio-Markers. Jaffe AS, et al. Among authors: apple fs. J Am Coll Cardiol. 2023 Jul 4;82(1):60-69. doi: 10.1016/j.jacc.2023.04.040. J Am Coll Cardiol. 2023. PMID: 37380305 Review.
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on presentation to exclude acute myocardial infarction with high clinical sensitivity and negative predictive value. ...
The term "single-sample rule-out" refers to the ability of very low concentrations of high-sensitivity cardiac troponin (hs-cTn) on p …
Rapid, robust, and sustainable antibody responses to mRNA COVID-19 vaccine in convalescent COVID-19 individuals.
Racine-Brzostek SE, Yee JK, Sukhu A, Qiu Y, Rand S, Barone PD, Hao Y, Yang HS, Meng QH, Apple FS, Shi Y, Chadburn A, Golden E, Formenti SC, Cushing MM, Zhao Z. Racine-Brzostek SE, et al. Among authors: apple fs. JCI Insight. 2021 Oct 22;6(20):e151477. doi: 10.1172/jci.insight.151477. JCI Insight. 2021. PMID: 34499052 Free PMC article.
Also, despite decreasing levels in TAb and SNAb over time, long-term avidity may be a measure worth evaluating and possibly correlating to vaccine efficacy....
Also, despite decreasing levels in TAb and SNAb over time, long-term avidity may be a measure worth evaluating and possibly correlati …
Cardiac Troponin Testing in Patients with COVID-19: A Strategy for Testing and Reporting Results.
Kavsak PA, Hammarsten O, Worster A, Smith SW, Apple FS. Kavsak PA, et al. Among authors: apple fs. Clin Chem. 2021 Jan 8;67(1):107-113. doi: 10.1093/clinchem/hvaa225. Clin Chem. 2021. PMID: 33045044 Free PMC article. Review.
CONTENT: The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview the strengths and weaknesses of selected studies evaluating cardiac troponin in patients with COVID-19, and c) to recommend testing strategies …
CONTENT: The purpose of this mini-review is: a) to review the pathophysiology of SARS-CoV-2 and the cardiovascular system, b) to overview th …
Copeptin to rule out myocardial infarction in Blacks versus Caucasians.
Beri N, Daniels LB, Jaffe A, Mueller C, Anand I, Peacock WF, Hollander JE, DeFilippi C, Schreiber D, McCord J, Limkakeng AT, Wu AHB, Apple FS, Diercks DB, Nagurney JT, Nowak RM, Cannon CM, Clopton P, Neath SX, Christenson RH, Hogan C, Vilke G, Maisel A. Beri N, et al. Among authors: apple fs. Eur Heart J Acute Cardiovasc Care. 2019 Aug;8(5):395-403. doi: 10.1177/2048872618772500. Epub 2018 May 8. Eur Heart J Acute Cardiovasc Care. 2019. PMID: 29737180 Clinical Trial.
After controlling for age, hypertension, heart failure, chronic kidney disease and body mass index in a logistic regression model, the interaction term had a P value of 0.03. A cut-off of 6 pmol/l showed similar sensitivity in Caucasians as 14 pmol/l in Blacks. ...
After controlling for age, hypertension, heart failure, chronic kidney disease and body mass index in a logistic regression model, the inter …
Type 1 and 2 Myocardial Infarction and Myocardial Injury: Clinical Transition to High-Sensitivity Cardiac Troponin I.
Sandoval Y, Smith SW, Sexter A, Thordsen SE, Bruen CA, Carlson MD, Dodd KW, Driver BE, Hu Y, Jacoby K, Johnson BK, Love SA, Moore JC, Schulz K, Scott NL, Apple FS. Sandoval Y, et al. Among authors: apple fs. Am J Med. 2017 Dec;130(12):1431-1439.e4. doi: 10.1016/j.amjmed.2017.05.049. Epub 2017 Jul 21. Am J Med. 2017. PMID: 28739197
Compared with patients without myonecrosis, type 2 myocardial infarction and myocardial injury have worse short-term outcomes, with mortality rates >20% at 2 years. hs-cTnI assay does not lead to more myocardial injury or infarction....
Compared with patients without myonecrosis, type 2 myocardial infarction and myocardial injury have worse short-term outcomes, with m …
High-sensitivity cardiac troponin assays and unstable angina.
Sandoval Y, Apple FS, Smith SW. Sandoval Y, et al. Among authors: apple fs. Eur Heart J Acute Cardiovasc Care. 2018 Mar;7(2):120-128. doi: 10.1177/2048872616658591. Epub 2016 Jul 7. Eur Heart J Acute Cardiovasc Care. 2018. PMID: 27388716 Review.
The term unstable angina has been conventionally applied to patients with myocardial ischemia without myocardial necrosis. ...
The term unstable angina has been conventionally applied to patients with myocardial ischemia without myocardial necrosis. ...
Midregional proadrenomedullin predicts mortality and major adverse cardiac events in patients presenting with chest pain: results from the CHOPIN trial.
Shah KS, Marston NA, Mueller C, Neath SX, Christenson RH, McCord J, Nowak RM, Vilke GM, Daniels LB, Hollander JE, Apple FS, Cannon CM, Nagurney J, Schreiber D, deFilippi C, Hogan CJ, Diercks DB, Limkakeng A, Anand IS, Wu AH, Clopton P, Jaffe AS, Peacock WF, Maisel AS. Shah KS, et al. Among authors: apple fs. Acad Emerg Med. 2015 May;22(5):554-63. doi: 10.1111/acem.12649. Epub 2015 Apr 23. Acad Emerg Med. 2015. PMID: 25908114 Free article. Clinical Trial.
MR-proADM, history of coronary artery disease (CAD), and hypertension were predictors of short-term MACE, while history of CAD, hypertension, cTnI, and MR-proADM were predictors of long-term MACE. ...
MR-proADM, history of coronary artery disease (CAD), and hypertension were predictors of short-term MACE, while history of CAD, hyper …
Multiple biomarkers including cardiac troponins T and I measured by high-sensitivity assays, as predictors of long-term mortality in patients with chronic renal failure who underwent dialysis.
Hickman PE, McGill D, Potter JM, Koerbin G, Apple FS, Talaulikar G. Hickman PE, et al. Among authors: apple fs. Am J Cardiol. 2015 Jun 1;115(11):1601-6. doi: 10.1016/j.amjcard.2015.02.066. Epub 2015 Mar 14. Am J Cardiol. 2015. PMID: 25851798
There is a high cardiac mortality in patients on long-term renal dialysis. No studies have reported long-term outcomes relating to both high-sensitivity cardiac troponin T (hs-cTnT) and high-sensitivity cardiac troponin I (hs-cTnI) in these patients. Patients who un …
There is a high cardiac mortality in patients on long-term renal dialysis. No studies have reported long-term outcomes relatin …
19 results