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Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.
Allard JS, Perez EJ, Fukui K, Carpenter P, Ingram DK, de Cabo R. Allard JS, et al. Behav Brain Res. 2016 Mar 15;301:1-9. doi: 10.1016/j.bbr.2015.12.012. Epub 2015 Dec 14. Behav Brain Res. 2016. PMID: 26698400 Free PMC article.
Long-term use of anti-diabetic agents has become commonplace as rates of obesity, metabolic syndrome and diabetes continue to escalate. ...In this study, we examined the effect of long-term metformin treatment on brain neurotrophins and cognition in aged male C57Bl/ …
Long-term use of anti-diabetic agents has become commonplace as rates of obesity, metabolic syndrome and diabetes continue to escalat …
SIRT1 is essential for normal cognitive function and synaptic plasticity.
Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. Michán S, et al. Among authors: allard js. J Neurosci. 2010 Jul 21;30(29):9695-707. doi: 10.1523/JNEUROSCI.0027-10.2010. J Neurosci. 2010. PMID: 20660252 Free PMC article.
Dietary interventions to extend life span and health span based on calorie restriction.
Minor RK, Allard JS, Younts CM, Ward TM, de Cabo R. Minor RK, et al. Among authors: allard js. J Gerontol A Biol Sci Med Sci. 2010 Jul;65(7):695-703. doi: 10.1093/gerona/glq042. Epub 2010 Apr 6. J Gerontol A Biol Sci Med Sci. 2010. PMID: 20371545 Free PMC article. Review.
The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, …
The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long …