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Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials.
Petrushina I, Hovakimyan A, Harahap-Carrillo IS, Davtyan H, Antonyan T, Chailyan G, Kazarian K, Antonenko M, Jullienne A, Hamer MM, Obenaus A, King O, Zagorski K, Blurton-Jones M, Cribbs DH, Lander H, Ghochikyan A, Agadjanyan MG. Petrushina I, et al. Among authors: agadjanyan mg. Neurobiol Dis. 2020 Jun;139:104823. doi: 10.1016/j.nbd.2020.104823. Epub 2020 Feb 28. Neurobiol Dis. 2020. PMID: 32119976 Free PMC article. Review.
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations with three doses of AV-1959D. ...
In Tg2576 mice with established amyloid pathology, we did not observe short- or long-term toxicities after multiple immunizations wit …
Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology.
Joly-Amado A, Davtyan H, Serraneau K, Jules P, Zitnyar A, Pressman E, Zagorski K, Antonyan T, Hovakimyan A, Paek HJ, Gordon MN, Cribbs DH, Petrovsky N, Agadjanyan MG, Ghochikyan A, Morgan D. Joly-Amado A, et al. Among authors: agadjanyan mg. Neurobiol Dis. 2020 Feb;134:104636. doi: 10.1016/j.nbd.2019.104636. Epub 2019 Oct 17. Neurobiol Dis. 2020. PMID: 31629891 Free PMC article.
These experimental animals displayed an improvement in short-term memory during a novel object recognition test. However, impairments in other behavioral tasks were not prevented by AV-1980R/A vaccinations. ...
These experimental animals displayed an improvement in short-term memory during a novel object recognition test. However, impairments …
Epitope-based DNA vaccine for Alzheimer's disease: translational study in macaques.
Evans CF, Davtyan H, Petrushina I, Hovakimyan A, Davtyan A, Hannaman D, Cribbs DH, Agadjanyan MG, Ghochikyan A. Evans CF, et al. Among authors: agadjanyan mg. Alzheimers Dement. 2014 May;10(3):284-95. doi: 10.1016/j.jalz.2013.04.505. Epub 2013 Jul 31. Alzheimers Dement. 2014. PMID: 23916838 Free PMC article.
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long-term, potent anti-Abeta antibodies and cellular immune responses specific to foreign T-helper epitopes but not to self-Abeta. ...
Functional activities of anti-Abeta antibodies generated in response to vaccination were assessed in vitro. RESULTS: AV-1955 generates long- …