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Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study.
Teo K, Fowler RA, Adhikari NKJ, Rishu A, Tsang JLY, Binnie A, Murthy S; Canadian Critical Care Trials Group. Teo K, et al. Among authors: adhikari nkj. CMAJ Open. 2023 Jul 4;11(4):E615-E620. doi: 10.9778/cmajo.20220129. Print 2023 Jul-Aug. CMAJ Open. 2023. PMID: 37402556 Free PMC article.
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term funding of platform trials that engage academic and community hospitals are potential solutions to improve trial start-up efficiency....
Adoption of template clinical trial agreements, greater harmonization or central coordination of ethics submissions, and long-term fu …
Lower Versus Higher Exposure to Vasopressor Therapy in Vasodilatory Hypotension: A Systematic Review With Meta-Analysis.
Richards-Belle A, Hylands M, Muttalib F, Taran S, Rochwerg B, Day A, Mouncey PR, Radermacher P, Couban R, Asfar P, Adhikari NKJ, Lamontagne F. Richards-Belle A, et al. Among authors: adhikari nkj. Crit Care Med. 2023 Feb 1;51(2):254-266. doi: 10.1097/CCM.0000000000005736. Epub 2022 Nov 18. Crit Care Med. 2023. PMID: 36398968 Free PMC article.
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- and longer-term mortality, use of life-sustaining therapies, vasopressor-related complications, neurologic outcome, and quality of l …
DATA EXTRACTION: The primary outcome was 90-day all-cause mortality, with seven prespecified subgroups. Secondary outcomes included shorter- …
Short-and long-term outcomes of sustained low efficiency dialysis vs continuous renal replacement therapy in critically ill patients with acute kidney injury.
Harvey AK, Burns KEA, McArthur E, Adhikari NKJ, Li D, Kitchlu A, Meraz-Munõz A, Garg AX, Nash DM, Perez-Sanchez A, Beaubien-Souligny W, Bagshaw SM, Friedrich JO, Silver SA, Wald R. Harvey AK, et al. Among authors: adhikari nkj. J Crit Care. 2021 Apr;62:76-81. doi: 10.1016/j.jcrc.2020.11.003. Epub 2020 Nov 22. J Crit Care. 2021. PMID: 33290929
However, there is limited information on the short- and long-term outcomes of SLED compared to CRRT. METHODS: We conducted a retrospective cohort study of patients with AKI who commenced either SLED or CRRT in ICUs at a tertiary care hospital in Toronto, Canada. ...
However, there is limited information on the short- and long-term outcomes of SLED compared to CRRT. METHODS: We conducted a retrospe …
Rate and risk factors for rehospitalisation in sepsis survivors: systematic review and meta-analysis.
Shankar-Hari M, Saha R, Wilson J, Prescott HC, Harrison D, Rowan K, Rubenfeld GD, Adhikari NKJ. Shankar-Hari M, et al. Among authors: adhikari nkj. Intensive Care Med. 2020 Apr;46(4):619-636. doi: 10.1007/s00134-019-05908-3. Epub 2020 Jan 23. Intensive Care Med. 2020. PMID: 31974919 Free PMC article. Review.
PURPOSE: Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and independent predictors for rehospitalisation in adult sepsis survivors. ...
PURPOSE: Sepsis survivors have a higher risk of rehospitalisation and of long-term mortality. We assessed the rate, diagnosis, and in …
The harm of high-frequency oscillatory ventilation (HFOV) in ARDS is not related to a high baseline risk of acute cor pulmonale or short-term changes in hemodynamics.
Angriman F, Ferreyro BL, Donaldson L, Cuthbertson BH, Ferguson ND, Bollen CW, Bachman TE, Lamontagne F, Adhikari NKJ. Angriman F, et al. Among authors: adhikari nkj. Intensive Care Med. 2020 Jan;46(1):132-134. doi: 10.1007/s00134-019-05806-8. Epub 2019 Oct 29. Intensive Care Med. 2020. PMID: 31664500 Free PMC article. No abstract available.
Barriers to supportive care during the Ebola virus disease outbreak in West Africa: Results of a qualitative study.
Loignon C, Nouvet E, Couturier F, Benhadj L, Adhikari NKJ, Murthy S, Fowler RA, Lamontagne F. Loignon C, et al. Among authors: adhikari nkj. PLoS One. 2018 Sep 5;13(9):e0201091. doi: 10.1371/journal.pone.0201091. eCollection 2018. PLoS One. 2018. PMID: 30183718 Free PMC article. Clinical Trial.
Addressing these in the inter-outbreak period will be useful to improve patient care and outcomes during inevitable future outbreaks. Promoting community trust and engagement through long-term capacity building of the healthcare workforce and infrastructure would increase …
Addressing these in the inter-outbreak period will be useful to improve patient care and outcomes during inevitable future outbreaks. Promot …
Development of a short course on management of critically ill patients with acute respiratory infection and impact on clinician knowledge in resource-limited intensive care units.
Diaz JV, Ortiz JR, Lister P, Shindo N, Adhikari NKJ; WHO Critical Care Training Short Course collaborators. Diaz JV, et al. Among authors: adhikari nkj. Influenza Other Respir Viruses. 2018 Sep;12(5):649-655. doi: 10.1111/irv.12569. Epub 2018 May 26. Influenza Other Respir Viruses. 2018. PMID: 29727522 Free PMC article.
Collaboration between WHO, clinical experts, instructional designers, Ministries of Health and local clinician-leaders facilitated course delivery. Future work should assess its impact on longer-term knowledge retention and on processes and outcomes of care....
Collaboration between WHO, clinical experts, instructional designers, Ministries of Health and local clinician-leaders facilitated course de …
Effect of Early Versus Late Tracheostomy or Prolonged Intubation in Critically Ill Patients with Acute Brain Injury: A Systematic Review and Meta-Analysis.
McCredie VA, Alali AS, Scales DC, Adhikari NK, Rubenfeld GD, Cuthbertson BH, Nathens AB. McCredie VA, et al. Neurocrit Care. 2017 Feb;26(1):14-25. doi: 10.1007/s12028-016-0297-z. Neurocrit Care. 2017. PMID: 27601069 Review.
Two reviewers extracted data and assessed risk of bias. Outcomes included long-term mortality (primary), short-term mortality, duration of mechanical ventilation, complications, and liberation from ventilation without a tracheostomy. ...However, waiting longer leads …
Two reviewers extracted data and assessed risk of bias. Outcomes included long-term mortality (primary), short-term mortality, …
Risk factors for and prediction of mortality in critically ill medical-surgical patients receiving heparin thromboprophylaxis.
Li G, Thabane L, Cook DJ, Lopes RD, Marshall JC, Guyatt G, Holbrook A, Akhtar-Danesh N, Fowler RA, Adhikari NKJ, Taylor R, Arabi YM, Chittock D, Dodek P, Freitag AP, Walter SD, Heels-Ansdell D, Levine MAH. Li G, et al. Among authors: adhikari nkj. Ann Intensive Care. 2016 Dec;6(1):18. doi: 10.1186/s13613-016-0116-x. Epub 2016 Feb 27. Ann Intensive Care. 2016. PMID: 26921148 Free PMC article.
The new model predicting 60-day hospital mortality incorporated APACHE II score (main effect: hazard ratio (HR) = 0.97 for per-point increase), body mass index (BMI) (main effect: HR = 0.92 for per-point increase), medical admission versus surgical (HR = 1.67), use of inotropes o …
The new model predicting 60-day hospital mortality incorporated APACHE II score (main effect: hazard ratio (HR) = 0.97 for per-point increas …
Changing incidence and outcomes following dialysis-requiring acute kidney injury among critically ill adults: a population-based cohort study.
Wald R, McArthur E, Adhikari NK, Bagshaw SM, Burns KE, Garg AX, Harel Z, Kitchlu A, Mazer CD, Nash DM, Scales DC, Silver SA, Ray JG, Friedrich JO. Wald R, et al. Am J Kidney Dis. 2015 Jun;65(6):870-7. doi: 10.1053/j.ajkd.2014.10.017. Epub 2014 Dec 18. Am J Kidney Dis. 2015. PMID: 25533599
This was accompanied by a significant decline in mortality, but the risk of long-term dialysis dependence continues to affect a substantial minority of surviving patients with no clear evidence of improvement over time....
This was accompanied by a significant decline in mortality, but the risk of long-term dialysis dependence continues to affect a subst …
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