Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1995 1
1999 1
2006 1
2010 1
2011 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

5 results

Results by year

Filters applied: . Clear all
Page 1
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.
Rozkalne A, Hyman BT, Spires-Jones TL. Rozkalne A, et al. Neurobiol Dis. 2011 Mar;41(3):650-4. doi: 10.1016/j.nbd.2010.11.014. Epub 2010 Dec 4. Neurobiol Dis. 2011. PMID: 21134458 Free PMC article.
In this study, we pharmacologically inhibited calcineurin with FK506 treatment to test the hypothesis that calcineurin inhibition will allow recovery of plaque-associated synapse loss. We found that in plaque bearing transgenic mice, short term (1 week) FK506 treatment res …
In this study, we pharmacologically inhibited calcineurin with FK506 treatment to test the hypothesis that calcineurin inhibition will allow …
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.
Broekman ML, Comer LA, Hyman BT, Sena-Esteves M. Broekman ML, et al. Neuroscience. 2006;138(2):501-10. doi: 10.1016/j.neuroscience.2005.11.057. Epub 2006 Jan 18. Neuroscience. 2006. PMID: 16414198
Adeno-associated virus (AAV) vectors have gained a preeminent position in the field of gene delivery to the normal brain through their ability to achieve extensive transduction of neurons and to mediate long-term gene expression with no apparent toxicity. In adult animals …
Adeno-associated virus (AAV) vectors have gained a preeminent position in the field of gene delivery to the normal brain through their abili …
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.
Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK. Chapman PF, et al. Nat Neurosci. 1999 Mar;2(3):271-6. doi: 10.1038/6374. Nat Neurosci. 1999. PMID: 10195221
Although aged APP transgenic mice exhibit normal fast synaptic transmission and short term plasticity, they are severely impaired in in-vitro and in-vivo long-term potentiation (LTP) in both the CA1 and dentate gyrus regions of the hippocampus. ...
Although aged APP transgenic mice exhibit normal fast synaptic transmission and short term plasticity, they are severely impaired in …
CA3 neuronal degeneration follows chronic entorhinal cortex lesions.
Poduri A, Beason-Held LL, Moss MB, Rosene DL, Hyman BT. Poduri A, et al. Neurosci Lett. 1995 Sep 1;197(1):1-4. doi: 10.1016/0304-3940(95)11879-2. Neurosci Lett. 1995. PMID: 8545043 Free article.
Entorhinal cortex lesions are a common experimental paradigm to study memory function and neural plasticity after hippocampal deafferentation. The long term consequences of such lesions are of particular interest both in the context of these models and because pathological …
Entorhinal cortex lesions are a common experimental paradigm to study memory function and neural plasticity after hippocampal deafferentatio …
The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease.
Rebeck GW, Marzloff K, Hyman BT. Rebeck GW, et al. Neurosci Lett. 1993 Apr 2;152(1-2):165-8. doi: 10.1016/0304-3940(93)90509-j. Neurosci Lett. 1993. PMID: 7685863
NADPH diaphorase is thought to reflect the presence of nitric oxide synthase. Because nitric oxide has been implicated in long-term potentiation, changes in its expression could reflect loss of synapses important for memory formation....
NADPH diaphorase is thought to reflect the presence of nitric oxide synthase. Because nitric oxide has been implicated in long-term p …