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2009 2
2010 4
2011 2
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15 results

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Page 1
Time is ticking faster for long genes in aging.
Soheili-Nezhad S, Ibáñez-Solé O, Izeta A, Hoeijmakers JHJ, Stoeger T. Soheili-Nezhad S, et al. Trends Genet. 2024 Apr;40(4):299-312. doi: 10.1016/j.tig.2024.01.009. Epub 2024 Mar 21. Trends Genet. 2024. PMID: 38519330 Free article. Review.
Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and their expression in various cell types, species, and diseases. We term this phenomenon gene-length-dependent transcription decline (GL …
Recent studies of aging organisms have identified a systematic phenomenon, characterized by a negative correlation between gene length and t …
Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal.
Kuehnemann C, Hughes JB, Desprez PY, Melov S, Wiley CD, Campisi J. Kuehnemann C, et al. Aging Cell. 2023 Jan;22(1):e13750. doi: 10.1111/acel.13750. Epub 2022 Dec 20. Aging Cell. 2023. PMID: 36539941 Free PMC article.
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. However, long-term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nuc …
Antiretroviral drugs have dramatically improved the prognosis of HIV-infected patients, with strikingly reduced morbidity and mortality. How …
Nutritional Preconditioning in Cancer Treatment in Relation to DNA Damage and Aging.
van den Boogaard WMC, van den Heuvel-Eibrink MM, Hoeijmakers JHJ, Vermeij WP. van den Boogaard WMC, et al. Annu Rev Cancer Biol. 2021 Mar;5:161-179. doi: 10.1146/annurev-cancerbio-060820-090737. Epub 2020 Dec 2. Annu Rev Cancer Biol. 2021. PMID: 35474917 Free PMC article.
Since fasting and DR decrease DNA damage and its effects, nutritional preconditioning holds promise for improving (cancer) therapy and preventing short- and long-term side effects of anticancer treatments. This review provides an overview of the link between aging and canc …
Since fasting and DR decrease DNA damage and its effects, nutritional preconditioning holds promise for improving (cancer) therapy and preve …
Comprehensive miRNA Profiling of Skeletal Muscle and Serum in Induced and Normal Mouse Muscle Atrophy During Aging.
Jung HJ, Lee KP, Milholland B, Shin YJ, Kang JS, Kwon KS, Suh Y. Jung HJ, et al. J Gerontol A Biol Sci Med Sci. 2017 Oct 12;72(11):1483-1491. doi: 10.1093/gerona/glx025. J Gerontol A Biol Sci Med Sci. 2017. PMID: 28329037 Free PMC article.
Muscular atrophy can also be induced by disuse associated with long-term bed rest or disease. Although miRNAs regulate muscle growth, regeneration, and aging, their potential role in acute muscle atrophy is poorly understood. ...Here, we report comprehensive miRNA expressi …
Muscular atrophy can also be induced by disuse associated with long-term bed rest or disease. Although miRNAs regulate muscle growth, …
Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse.
Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Demaria M, et al. Cancer Discov. 2017 Feb;7(2):165-176. doi: 10.1158/2159-8290.CD-16-0241. Epub 2016 Dec 15. Cancer Discov. 2017. PMID: 27979832 Free PMC article.
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, in …
Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist a …
Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain.
Andriani GA, Vijg J, Montagna C. Andriani GA, et al. Mech Ageing Dev. 2017 Jan;161(Pt A):19-36. doi: 10.1016/j.mad.2016.03.007. Epub 2016 Mar 21. Mech Ageing Dev. 2017. PMID: 27013377 Free PMC article. Review.
Aneuploidy is commonly linked to pathological states. It is a hallmark of spontaneous abortions and birth defects and it is observed virtually in every human tumor, therefore being generally regarded as detrimental for the development or the maturation of tissues under phy …
Aneuploidy is commonly linked to pathological states. It is a hallmark of spontaneous abortions and birth defects and it is observed …
Transcriptional profiling reveals progeroid Ercc1(-/Δ) mice as a model system for glomerular aging.
Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE. Schermer B, et al. BMC Genomics. 2013 Aug 16;14:559. doi: 10.1186/1471-2164-14-559. BMC Genomics. 2013. PMID: 23947592 Free PMC article.
An unexpectedly high number of 77 genes were differentially regulated in both WT and Ercc1(-/delta) mice (p < 0.0001). GO term enrichment analysis revealed these genes to be involved in immune and inflammatory response, cell death, and chemotaxis. ...

An unexpectedly high number of 77 genes were differentially regulated in both WT and Ercc1(-/delta) mice (p < 0.0001). GO term enr

…
Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors.
Livi CB, Hardman RL, Christy BA, Dodds SG, Jones D, Williams C, Strong R, Bokov A, Javors MA, Ikeno Y, Hubbard G, Hasty P, Sharp ZD. Livi CB, et al. Aging (Albany NY). 2013 Feb;5(2):100-10. doi: 10.18632/aging.100533. Aging (Albany NY). 2013. PMID: 23454836 Free PMC article.
Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1+/- mice, suggesting that the beneficial response to DR is dependent on pRb1. Since long-term eRapa treatment may at least partially mimic chronic DR in lifespan extension, we …
Previous results showed that diet restriction (DR) had minimal or no effect on the lifespan of Rb1+/- mice, suggesting that the beneficial r …
ATM suppresses SATB1-induced malignant progression in breast epithelial cells.
Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T. Ordinario E, et al. PLoS One. 2012;7(12):e51786. doi: 10.1371/journal.pone.0051786. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251624 Free PMC article.
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two other non-malignant breast epithelial cell lines, 184A1 and 184B4, enabled SATB1 to induce malignant phenotypes similar to that observed for M …
We found the reason for reduction to be phenotypic drift due to long-term cultivation of MCF10A. ATM knockdown in MCF10A-2 and two ot …
15 results