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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1988 1
1989 1
1990 2
1991 4
1992 2
1993 4
1994 1
1995 1
1996 1
1998 1
1999 2
2000 1
2001 1
2003 1
2004 1
2005 1
2006 7
2007 4
2008 6
2009 3
2010 5
2011 3
2012 7
2013 9
2014 18
2015 21
2016 26
2017 24
2018 34
2019 39
2020 39
2021 53
2022 76
2023 67
2024 25

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446 results

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Page 1
A transcription factor atlas of directed differentiation.
Joung J, Ma S, Tay T, Geiger-Schuller KR, Kirchgatterer PC, Verdine VK, Guo B, Arias-Garcia MA, Allen WE, Singh A, Kuksenko O, Abudayyeh OO, Gootenberg JS, Fu Z, Macrae RK, Buenrostro JD, Regev A, Zhang F. Joung J, et al. Cell. 2023 Jan 5;186(1):209-229.e26. doi: 10.1016/j.cell.2022.11.026. Cell. 2023. PMID: 36608654 Free PMC article.
To comprehensively understand TFs and the programs they control, we created a barcoded library of all annotated human TF splice isoforms (>3,500) and applied it to build a TF Atlas charting expression profiles of human embryonic stem cells (hESCs) overexpressing each TF …
To comprehensively understand TFs and the programs they control, we created a barcoded library of all annotated human TF splice isofo …
Emerging therapeutic opportunities for integrin inhibitors.
Slack RJ, Macdonald SJF, Roper JA, Jenkins RG, Hatley RJD. Slack RJ, et al. Nat Rev Drug Discov. 2022 Jan;21(1):60-78. doi: 10.1038/s41573-021-00284-4. Epub 2021 Sep 17. Nat Rev Drug Discov. 2022. PMID: 34535788 Free PMC article. Review.
Optimized single-nucleus transcriptional profiling by combinatorial indexing.
Martin BK, Qiu C, Nichols E, Phung M, Green-Gladden R, Srivatsan S, Blecher-Gonen R, Beliveau BJ, Trapnell C, Cao J, Shendure J. Martin BK, et al. Nat Protoc. 2023 Jan;18(1):188-207. doi: 10.1038/s41596-022-00752-0. Epub 2022 Oct 19. Nat Protoc. 2023. PMID: 36261634 Free PMC article. Review.
Here, we report a simplified, optimized version of the sci-RNA-seq protocol with three rounds of split-pool indexing that is faster, more robust and more sensitive and has a higher yield than the original protocol, with reagent costs on the order of 1 cent per cell or less. The t …
Here, we report a simplified, optimized version of the sci-RNA-seq protocol with three rounds of split-pool indexing that is faster, more ro …
Functional viromic screens uncover regulatory RNA elements.
Seo JJ, Jung SJ, Yang J, Choi DE, Kim VN. Seo JJ, et al. Cell. 2023 Jul 20;186(15):3291-3306.e21. doi: 10.1016/j.cell.2023.06.007. Epub 2023 Jul 5. Cell. 2023. PMID: 37413987
Here, we conducted a screening of 30,367 viral segments from 143 species representing 96 genera and 37 families. Using a library of viral segments in 3' UTR, we identified hundreds of elements impacting RNA abundance, translation, and nucleocytoplasmic distribution. ...
Here, we conducted a screening of 30,367 viral segments from 143 species representing 96 genera and 37 families. Using a library of v …
Respiratory syncytial virus entry and how to block it.
Battles MB, McLellan JS. Battles MB, et al. Nat Rev Microbiol. 2019 Apr;17(4):233-245. doi: 10.1038/s41579-019-0149-x. Nat Rev Microbiol. 2019. PMID: 30723301 Free PMC article. Review.
RNA-guided DNA insertion with CRISPR-associated transposases.
Strecker J, Ladha A, Gardner Z, Schmid-Burgk JL, Makarova KS, Koonin EV, Zhang F. Strecker J, et al. Science. 2019 Jul 5;365(6448):48-53. doi: 10.1126/science.aax9181. Epub 2019 Jun 6. Science. 2019. PMID: 31171706 Free PMC article.
Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases.
Yarnall MTN, Ioannidi EI, Schmitt-Ulms C, Krajeski RN, Lim J, Villiger L, Zhou W, Jiang K, Garushyants SK, Roberts N, Zhang L, Vakulskas CA, Walker JA 2nd, Kadina AP, Zepeda AE, Holden K, Ma H, Xie J, Gao G, Foquet L, Bial G, Donnelly SK, Miyata Y, Radiloff DR, Henderson JM, Ujita A, Abudayyeh OO, Gootenberg JS. Yarnall MTN, et al. Nat Biotechnol. 2023 Apr;41(4):500-512. doi: 10.1038/s41587-022-01527-4. Epub 2022 Nov 24. Nat Biotechnol. 2023. PMID: 36424489 Free PMC article.
Non-viral precision T cell receptor replacement for personalized cell therapy.
Foy SP, Jacoby K, Bota DA, Hunter T, Pan Z, Stawiski E, Ma Y, Lu W, Peng S, Wang CL, Yuen B, Dalmas O, Heeringa K, Sennino B, Conroy A, Bethune MT, Mende I, White W, Kukreja M, Gunturu S, Humphrey E, Hussaini A, An D, Litterman AJ, Quach BB, Ng AHC, Lu Y, Smith C, Campbell KM, Anaya D, Skrdlant L, Huang EY, Mendoza V, Mathur J, Dengler L, Purandare B, Moot R, Yi MC, Funke R, Sibley A, Stallings-Schmitt T, Oh DY, Chmielowski B, Abedi M, Yuan Y, Sosman JA, Lee SM, Schoenfeld AJ, Baltimore D, Heath JR, Franzusoff A, Ribas A, Rao AV, Mandl SJ. Foy SP, et al. Nature. 2023 Mar;615(7953):687-696. doi: 10.1038/s41586-022-05531-1. Epub 2022 Nov 10. Nature. 2023. PMID: 36356599 Free PMC article. Clinical Trial.
We also inserted into the TRAC locus two chains of a neoantigen-specific TCR (neoTCR) isolated from circulating T cells of patients. The neoTCRs were isolated using a personalized library of soluble predicted neoantigen-HLA capture reagents. Sixteen patients with different …
We also inserted into the TRAC locus two chains of a neoantigen-specific TCR (neoTCR) isolated from circulating T cells of patients. The neo …
Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials.
Chiavaroli L, Lee D, Ahmed A, Cheung A, Khan TA, Blanco S, Mejia, Mirrahimi A, Jenkins DJA, Livesey G, Wolever TMS, Rahelić D, Kahleová H, Salas-Salvadó J, Kendall CWC, Sievenpiper JL. Chiavaroli L, et al. BMJ. 2021 Aug 4;374:n1651. doi: 10.1136/bmj.n1651. BMJ. 2021. PMID: 34348965 Free PMC article.
DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: Medline, Embase, and the Cochrane Library searched up to 13 May 2021. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomised controlled trials of three or more weeks investigating th …
DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: Medline, Embase, and the Cochrane Library …
446 results