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Long-term use of selective decontamination of the digestive tract does not increase antibiotic resistance: a 5-year prospective cohort study.
Ochoa-Ardila ME, García-Cañas A, Gómez-Mediavilla K, González-Torralba A, Alía I, García-Hierro P, Taylor N, van Saene HK, de la Cal MA. Ochoa-Ardila ME, et al. Among authors: van saene hk. Intensive Care Med. 2011 Sep;37(9):1458-65. doi: 10.1007/s00134-011-2307-0. Epub 2011 Jul 19. Intensive Care Med. 2011. PMID: 21769683
PURPOSE: Despite the evidence, the use of selective decontamination of the digestive tract (SDD) remains controversial, largely because of concerns that it may promote the emergence of antibiotic-resistant strains. The purpose of this study was to evaluate the long-term in …
PURPOSE: Despite the evidence, the use of selective decontamination of the digestive tract (SDD) remains controversial, largely because of c …
Surgical strategies in the management of ecthyma gangrenosum in paediatric oncology patients.
Khalil BA, Baillie CT, Kenny SE, Lamont GL, Turnock RR, Pizer BL, van Saene HF, Losty PD. Khalil BA, et al. Among authors: van saene hf. Pediatr Surg Int. 2008 Jul;24(7):793-7. doi: 10.1007/s00383-008-2159-z. Epub 2008 Apr 22. Pediatr Surg Int. 2008. PMID: 18427811
Between 1994 and 2005, all children with EG were identified. Case notes were reviewed. Hospital course and long-term outcome were documented. Ten patients were identified. Eight had acute lymphoblastic leukaemia, one child had acute myeloid leukaemia and another had rhabdo …
Between 1994 and 2005, all children with EG were identified. Case notes were reviewed. Hospital course and long-term outcome were doc …
Most nosocomial pneumonias are not due to nosocomial bacteria in ventilated patients. Evaluation of the accuracy of the 48 h time cut-off using carriage as the gold standard.
Silvestri L, Sarginson RE, Hughes J, Milanese M, Gregori D, Van Saene HK. Silvestri L, et al. Among authors: van saene hk. Anaesth Intensive Care. 2002 Jun;30(3):275-82. doi: 10.1177/0310057X0203000303. Anaesth Intensive Care. 2002. PMID: 12075633
A prospective observational cohort study was undertaken with two endpoints: (1) to compare the time cut-off of 48h and the carrier state criterion for classifying lower airway infections in adult and paediatric long-term ventilated patients, and (2) to evaluate the potenti …
A prospective observational cohort study was undertaken with two endpoints: (1) to compare the time cut-off of 48h and the carrier state cri …
Selective decontamination of the digestive tract: a life saver.
Silvestri L, Mannucci F, van Saene HK. Silvestri L, et al. Among authors: van saene hk. J Hosp Infect. 2000 Jul;45(3):185-90. doi: 10.1053/jhin.2000.0737. J Hosp Infect. 2000. PMID: 10896796 Review.
Selective decontamination of the digestive tract (SDD), a strategy designed to prevent or minimize the impact of infection by potentially pathogenic micro-organisms in critically ill patients requiring long-term mechanical ventilation, comprises four component protocols, a …
Selective decontamination of the digestive tract (SDD), a strategy designed to prevent or minimize the impact of infection by potentially pa …
Bactericidal activity against coagulase-negative staphylococci is impaired in infants receiving long-term parenteral nutrition.
Okada Y, Klein NJ, van Saene HK, Webb G, Holzel H, Pierro A. Okada Y, et al. Among authors: van saene hk. Ann Surg. 2000 Feb;231(2):276-81. doi: 10.1097/00000658-200002000-00018. Ann Surg. 2000. PMID: 10674621 Free PMC article.
RESULTS: In study 1, infants receiving a normal enteral diet showed a high capacity to ingest and kill coagulase-negative staphylococci. In contrast, the blood of infants receiving long-term TPN showed a reduction in coagulase-negative staphylococci phagocytosis and killin …
RESULTS: In study 1, infants receiving a normal enteral diet showed a high capacity to ingest and kill coagulase-negative staphylococci. In …
[Selective decontamination of the digestive tract reduces mortality in intensive care patients].
Rommes JH, Zandstra DF, van Saene HK. Rommes JH, et al. Among authors: van saene hk. Ned Tijdschr Geneeskd. 1999 Mar 20;143(12):602-6. Ned Tijdschr Geneeskd. 1999. PMID: 10321285 Review. Dutch.
Selective decontamination of the digestive tract (SDD) is a strategy designed to prevent or minimize the impact of infections by potentially pathogenic micro-organisms in critically ill patients requiring long-term mechanical ventilation. SDD is a four-component protocol t …
Selective decontamination of the digestive tract (SDD) is a strategy designed to prevent or minimize the impact of infections by potentially …
Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic.
Cheng K, Smyth RL, Govan JR, Doherty C, Winstanley C, Denning N, Heaf DP, van Saene H, Hart CA. Cheng K, et al. Among authors: van saene h. Lancet. 1996 Sep 7;348(9028):639-42. doi: 10.1016/S0140-6736(96)05169-0. Lancet. 1996. PMID: 8782753
INTERPRETATION: This study provides the first molecular evidence of a long-term outbreak of P aeruginosa in a CF centre. We suggest that careful surveillance of the prevalence of antibiotic resistance in CF centres should be instituted with measures to prevent cross-infect …
INTERPRETATION: This study provides the first molecular evidence of a long-term outbreak of P aeruginosa in a CF centre. We suggest t …
Microbial translocation in neonates and infants receiving long-term parenteral nutrition.
Pierro A, van Saene HK, Donnell SC, Hughes J, Ewan C, Nunn AJ, Lloyd DA. Pierro A, et al. Among authors: van saene hk. Arch Surg. 1996 Feb;131(2):176-9. doi: 10.1001/archsurg.1996.01430140066018. Arch Surg. 1996. PMID: 8611075
OBJECTIVE: To explore whether episodes of endogenous septicemias due to microbial translocation are clinically relevant in neonates and infants who are receiving long-term parenteral nutrition (PN). DESIGN: Prospective observational cohort study of 2 years. ...
OBJECTIVE: To explore whether episodes of endogenous septicemias due to microbial translocation are clinically relevant in neonates and infa …
Hypoalbuminaemia in surgical neonates receiving parenteral nutrition.
Kenny SE, Pierro A, Isherwood D, Donnell SC, Van Saene HK, Lloyd DA. Kenny SE, et al. Among authors: van saene hk. J Pediatr Surg. 1995 Mar;30(3):454-7. doi: 10.1016/0022-3468(95)90054-3. J Pediatr Surg. 1995. PMID: 7760241

The reference range (27.9 to 50.9 g/L) for serum albumin was derived from measurements taken in 37 (22 term and 15 preterm) normal enterally fed newborn infants. HA group (serum albumin < 27.9 g/L) included 15 infants (27%); NA group (serum albumin > or = 27.9 g/L) i

The reference range (27.9 to 50.9 g/L) for serum albumin was derived from measurements taken in 37 (22 term and 15 preterm) normal en …
13 results