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4D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applications.
Kalogeropoulou M, Díaz-Payno PJ, Mirzaali MJ, van Osch GJVM, Fratila-Apachitei LE, Zadpoor AA. Kalogeropoulou M, et al. Among authors: van osch gjvm. Biofabrication. 2024 Feb 9;16(2). doi: 10.1088/1758-5090/ad1e6f. Biofabrication. 2024. PMID: 38224616 Review.
Here, we present an overview of the current developments of the 4D printing technology for TERM, with a focus on approaches to achieve temporal changes of the shape of the printed constructs that would enable biofabrication of highly complex structures. ...On the other han …
Here, we present an overview of the current developments of the 4D printing technology for TERM, with a focus on approaches to achiev …
Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair.
Zhou L, Xu J, Schwab A, Tong W, Xu J, Zheng L, Li Y, Li Z, Xu S, Chen Z, Zou L, Zhao X, van Osch GJVM, Wen C, Qin L. Zhou L, et al. Among authors: van osch gjvm. Bioact Mater. 2023 May 2;26:490-512. doi: 10.1016/j.bioactmat.2023.03.008. eCollection 2023 Aug. Bioact Mater. 2023. PMID: 37304336 Free PMC article. Review.
However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short-term durability. It prompts an urgent need for innovative approaches to pattern a pro-regenerative microenvironment and yield hyalin …
However, these treatments frequently result in mechanically inferior fibrocartilage, low cost-effectiveness, donor site morbidity, and short …
Intra-articular injection of triamcinolone acetonide sustains macrophage levels and aggravates osteophytosis during degenerative joint disease in mice.
Ferrao Blanco MN, Bastiaansen Jenniskens YM, Kops N, Chavli A, Narcisi R, Botter SM, Leenen PJM, van Osch GJVM, Fahy N. Ferrao Blanco MN, et al. Among authors: van osch gjvm. Br J Pharmacol. 2022 Jun;179(11):2771-2784. doi: 10.1111/bph.15780. Epub 2022 Jan 26. Br J Pharmacol. 2022. PMID: 34907535 Free PMC article.
CONCLUSION AND IMPLICATIONS: Intra-articular injection of TAA increases long-term synovial macrophage numbers and osteophytosis. Our findings suggest that TAA accentuates the progression of osteoarthritis-associated features when applied to an acutely inflamed knee....
CONCLUSION AND IMPLICATIONS: Intra-articular injection of TAA increases long-term synovial macrophage numbers and osteophytosis. Our …
Mechanically stimulated osteochondral organ culture for evaluation of biomaterials in cartilage repair studies.
Vainieri ML, Wahl D, Alini M, van Osch GJVM, Grad S. Vainieri ML, et al. Among authors: van osch gjvm. Acta Biomater. 2018 Nov;81:256-266. doi: 10.1016/j.actbio.2018.09.058. Epub 2018 Sep 28. Acta Biomater. 2018. PMID: 30273741 Free article.
The aim of current research is to develop a testing system to assess biomaterials for implants, that can permanently replace damaged cartilage with the original hyaline structure and can withstand the mechanical forces long term. Here, we present an osteochondral ex vivo c …
The aim of current research is to develop a testing system to assess biomaterials for implants, that can permanently replace damaged cartila …
Encapsulation of allogeneic mesenchymal stem cells in alginate extends local presence and therapeutic function.
Leijs MJ, Villafuertes E, Haeck JC, Koevoet WJ, Fernandez-Gutierrez B, Hoogduijn MJ, Verhaar JA, Bernsen MR, van Buul GM, van Osch GJ. Leijs MJ, et al. Among authors: van osch gj. Eur Cell Mater. 2017 Jan 30;33:43-58. doi: 10.22203/eCM.v033a04. Eur Cell Mater. 2017. PMID: 28138954 Free article.
Most studies investigating the properties of MSCs for therapeutic application use short term cultures of cells in monolayer. Since the physical environment of MSCs can influence their functionality, we evaluated the feasibility of preserving the immunomodulatory properties …
Most studies investigating the properties of MSCs for therapeutic application use short term cultures of cells in monolayer. Since th …
High fat diet accelerates cartilage repair in DBA/1 mice.
Wei W, Bastiaansen-Jenniskens YM, Suijkerbuijk M, Kops N, Bos PK, Verhaar JAN, Zuurmond AM, Dell'Accio F, van Osch GJVM. Wei W, et al. Among authors: van osch gjvm. J Orthop Res. 2017 Jun;35(6):1258-1264. doi: 10.1002/jor.23280. Epub 2017 Apr 18. J Orthop Res. 2017. PMID: 27147295 Free article.
In contrast to common wisdom, HFD accelerated intrinsic cartilage repair in DBA/1 mice on the short term. Resistance to HFD induced inflammatory and metabolic changes could be associated with accelerated cartilage repair. 2017 Orthopaedic Research Society. ...
In contrast to common wisdom, HFD accelerated intrinsic cartilage repair in DBA/1 mice on the short term. Resistance to HFD induced i …
Long-term expansion, enhanced chondrogenic potential, and suppression of endochondral ossification of adult human MSCs via WNT signaling modulation.
Narcisi R, Cleary MA, Brama PA, Hoogduijn MJ, Tüysüz N, ten Berge D, van Osch GJ. Narcisi R, et al. Among authors: van osch gj. Stem Cell Reports. 2015 Mar 10;4(3):459-72. doi: 10.1016/j.stemcr.2015.01.017. Epub 2015 Feb 26. Stem Cell Reports. 2015. PMID: 25733021 Free PMC article.
Here we report that the signaling protein WNT3A, in combination with FGF2, supports long-term expansion of human bone marrow-derived MSCs. The cells retained their chondrogenic potential and other phenotypic and functional properties of multipotent MSCs, which were gradual …
Here we report that the signaling protein WNT3A, in combination with FGF2, supports long-term expansion of human bone marrow-derived …
Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture.
van Buul GM, Villafuertes E, Bos PK, Waarsing JH, Kops N, Narcisi R, Weinans H, Verhaar JA, Bernsen MR, van Osch GJ. van Buul GM, et al. Among authors: van osch gj. Osteoarthritis Cartilage. 2012 Oct;20(10):1186-96. doi: 10.1016/j.joca.2012.06.003. Epub 2012 Jul 5. Osteoarthritis Cartilage. 2012. PMID: 22771777 Free article.
Clinically translatable cell tracking and quantification by MRI in cartilage repair using superparamagnetic iron oxides.
van Buul GM, Kotek G, Wielopolski PA, Farrell E, Bos PK, Weinans H, Grohnert AU, Jahr H, Verhaar JA, Krestin GP, van Osch GJ, Bernsen MR. van Buul GM, et al. Among authors: van osch gj. PLoS One. 2011 Feb 23;6(2):e17001. doi: 10.1371/journal.pone.0017001. PLoS One. 2011. PMID: 21373640 Free PMC article.
We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity, cell viability, long term metabolic cell activity, chondrogenic differentiation and hBMSC secretion profile. ...
We studied superparamagnetic iron oxides (SPIO) for labeling human bone marrow-derived mesenchymal stem cells (hBMSCs) regarding effectivity …
17 results