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The association between continuous ambulatory heart rate, heart rate variability, and 24-h rhythms of heart rate with familial longevity and aging.
Wiersema JM, Kamphuis AEP, Rohling JHT, Kervezee L, Akintola AA, Jansen SW, Slagboom PE, van Heemst D, van der Spoel E. Wiersema JM, et al. Among authors: van heemst d. Aging (Albany NY). 2022 Aug 16;14(18):7223-7239. doi: 10.18632/aging.204219. Epub 2022 Aug 16. Aging (Albany NY). 2022. PMID: 35980264 Free PMC article.
Interestingly, middle-aged participants had a less optimal HRV during long-term recordings in both the sleep and awake periods, which might indicate that their heart is less adaptable than that of young participants. ...
Interestingly, middle-aged participants had a less optimal HRV during long-term recordings in both the sleep and awake periods, which …
Validating biomarkers and models for epigenetic inference of alcohol consumption from blood.
Maas SCE, Vidaki A, Teumer A, Costeira R, Wilson R, van Dongen J, Beekman M, Völker U, Grabe HJ, Kunze S, Ladwig KH, van Meurs JBJ, Uitterlinden AG, Voortman T, Boomsma DI, Slagboom PE, van Heemst D, van der Kallen CJH, van den Berg LH, Waldenberger M, Völzke H, Peters A, Bell JT, Ikram MA, Ghanbari M, Kayser M. Maas SCE, et al. Among authors: van heemst d. Clin Epigenetics. 2021 Oct 26;13(1):198. doi: 10.1186/s13148-021-01186-3. Clin Epigenetics. 2021. PMID: 34702360 Free PMC article.
BACKGROUND: Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and other areas. ...
BACKGROUND: Information on long-term alcohol consumption is relevant for medical and public health research, disease therapy, and oth …
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.
Deelen J, Kettunen J, Fischer K, van der Spek A, Trompet S, Kastenmüller G, Boyd A, Zierer J, van den Akker EB, Ala-Korpela M, Amin N, Demirkan A, Ghanbari M, van Heemst D, Ikram MA, van Klinken JB, Mooijaart SP, Peters A, Salomaa V, Sattar N, Spector TD, Tiemeier H, Verhoeven A, Waldenberger M, Würtz P, Davey Smith G, Metspalu A, Perola M, Menni C, Geleijnse JM, Drenos F, Beekman M, Jukema JW, van Duijn CM, Slagboom PE. Deelen J, et al. Among authors: van heemst d. Nat Commun. 2019 Aug 20;10(1):3346. doi: 10.1038/s41467-019-11311-9. Nat Commun. 2019. PMID: 31431621 Free PMC article.
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals (age a …
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-stand …
Do senescence markers correlate in vitro and in situ within individual human donors?
Waaijer MEC, Gunn DA, van Heemst D, Slagboom PE, Sedivy JM, Dirks RW, Tanke HJ, Westendorp RGJ, Maier AB. Waaijer MEC, et al. Among authors: van heemst d. Aging (Albany NY). 2018 Feb 28;10(2):278-289. doi: 10.18632/aging.101389. Aging (Albany NY). 2018. PMID: 29500330 Free PMC article.
Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal fibroblasts were assessed for reactive oxygen species (ROS), telomere-associated foci (TAF), p16INK4a and senescence-associated beta-gal (S …
Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal …
Blood lipids influence DNA methylation in circulating cells.
Dekkers KF, van Iterson M, Slieker RC, Moed MH, Bonder MJ, van Galen M, Mei H, Zhernakova DV, van den Berg LH, Deelen J, van Dongen J, van Heemst D, Hofman A, Hottenga JJ, van der Kallen CJ, Schalkwijk CG, Stehouwer CD, Tigchelaar EF, Uitterlinden AG, Willemsen G, Zhernakova A, Franke L, 't Hoen PA, Jansen R, van Meurs J, Boomsma DI, van Duijn CM, van Greevenbroek MM, Veldink JH, Wijmenga C; BIOS Consortium; van Zwet EW, Slagboom PE, Jukema JW, Heijmans BT. Dekkers KF, et al. Among authors: van heemst d. Genome Biol. 2016 Jun 27;17(1):138. doi: 10.1186/s13059-016-1000-6. Genome Biol. 2016. PMID: 27350042 Free PMC article.
BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the d …
BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exp …
Lifestyle and youthful looks.
Gunn DA, Dick JL, van Heemst D, Griffiths CE, Tomlin CC, Murray PG, Griffiths TW, Ogden S, Mayes AE, Westendorp RG, Slagboom PE, de Craen AJ. Gunn DA, et al. Among authors: van heemst d. Br J Dermatol. 2015;172(5):1338-45. doi: 10.1111/bjd.13646. Epub 2015 Apr 15. Br J Dermatol. 2015. PMID: 25627783
CONCLUSIONS: Although associative in nature, these results support the notion that lifestyle factors can have long-term beneficial effects on youthful looks....
CONCLUSIONS: Although associative in nature, these results support the notion that lifestyle factors can have long-term beneficial ef …
High serum glucose levels are associated with a higher perceived age.
Noordam R, Gunn DA, Tomlin CC, Maier AB, Mooijaart SP, Slagboom PE, Westendorp RG, de Craen AJ, van Heemst D; Leiden Longevity Study Group. Noordam R, et al. Among authors: van heemst d. Age (Dordr). 2013 Feb;35(1):189-95. doi: 10.1007/s11357-011-9339-9. Epub 2011 Nov 20. Age (Dordr). 2013. PMID: 22102339 Free PMC article.
Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of long-term hyperglycemic exposure) were included as a fourth stratum. Considered confounding factors were gender, chronological age, …
Non-diabetic subjects (n = 569) were divided in three strata according to their glucose levels, and diabetic subjects (n = 33; as a proxy of …