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Long-Term Drug Therapy and Drug Discontinuations and Holidays for Osteoporosis Fracture Prevention: A Systematic Review.
Fink HA, MacDonald R, Forte ML, Rosebush CE, Ensrud KE, Schousboe JT, Nelson VA, Ullman K, Butler M, Olson CM, Taylor BC, Brasure M, Wilt TJ. Fink HA, et al. Ann Intern Med. 2019 Jul 2;171(1):37-50. doi: 10.7326/M19-0533. Epub 2019 Apr 23. Ann Intern Med. 2019. PMID: 31009947 Free article.
BACKGROUND: Optimal long-term osteoporosis drug treatment (ODT) is uncertain. PURPOSE: To summarize the effects of long-term ODT and ODT discontinuation and holidays. ...In women with osteopenia or osteoporosis, 6 years of zoledronic acid reduced clinical fractur …
BACKGROUND: Optimal long-term osteoporosis drug treatment (ODT) is uncertain. PURPOSE: To summarize the effects of long-term O …
Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review.
Fink HA, MacDonald R, Forte ML, Rosebush CE, Ensrud KE, Schousboe JT, Nelson VA, Ullman K, Butler M, Olson CM, Taylor BC, Brasure M, Wilt TJ. Fink HA, et al. Rockville (MD): Agency for Healthcare Research and Quality (US); 2019 Apr. Report No.: 19-EHC016-EF. Rockville (MD): Agency for Healthcare Research and Quality (US); 2019 Apr. Report No.: 19-EHC016-EF. PMID: 31216153 Free Books & Documents. Review.
OBJECTIVE: To summarize the effects of long-term osteoporosis drug treatment (ODT) and ODT discontinuation and holidays on fractures and harms. ...While absolute reductions in typical fractures with long-term bisphosphonates are large relative to incre …
OBJECTIVE: To summarize the effects of long-term osteoporosis drug treatment (ODT) and ODT discontinuation and holidays on …
Definition and Evolution of the Term Osteoporosis.
Poduval M, Vishwanathan K. Poduval M, et al. Indian J Orthop. 2023 Oct 31;57(Suppl 1):42-44. doi: 10.1007/s43465-023-01013-2. eCollection 2023 Dec. Indian J Orthop. 2023. PMID: 38107798 Review.
Osteoporosis is a metabolic bone disease in which the loss of bone mineral density causes the bone to become weaker and more susceptible to fracture. In the vulnerable individual, osteoporosis develops as a result of a combination of hereditary and env …
Osteoporosis is a metabolic bone disease in which the loss of bone mineral density causes the bone to become weaker and …
Postmenopausal osteoporosis treatment with antiresorptives: effects of discontinuation or long-term continuation on bone turnover and fracture risk--a perspective.
Boonen S, Ferrari S, Miller PD, Eriksen EF, Sambrook PN, Compston J, Reid IR, Vanderschueren D, Cosman F. Boonen S, et al. J Bone Miner Res. 2012 May;27(5):963-74. doi: 10.1002/jbmr.1570. Epub 2012 Mar 29. J Bone Miner Res. 2012. PMID: 22467094 Free article. Review.
Osteoporosis may be a lifelong condition. Robust data regarding the efficacy and safety of both long-term osteoporosis therapy and therapy discontinuation are therefore important. ...Similarly, the effects of rapid reversal of bone turnover upon discontinuati …
Osteoporosis may be a lifelong condition. Robust data regarding the efficacy and safety of both long-term osteoporosis therapy …
The clinical diagnosis of osteoporosis: a position statement from the National Bone Health Alliance Working Group.
Siris ES, Adler R, Bilezikian J, Bolognese M, Dawson-Hughes B, Favus MJ, Harris ST, Jan de Beur SM, Khosla S, Lane NE, Lindsay R, Nana AD, Orwoll ES, Saag K, Silverman S, Watts NB. Siris ES, et al. Osteoporos Int. 2014 May;25(5):1439-43. doi: 10.1007/s00198-014-2655-z. Epub 2014 Feb 28. Osteoporos Int. 2014. PMID: 24577348 Free PMC article.
INTRODUCTION: Osteoporosis is a common disorder of reduced bone strength that predisposes to an increased risk for fractures in older individuals. ...Finally, the term osteoporosis should be used to diagnose individuals with an elevated fracture …
INTRODUCTION: Osteoporosis is a common disorder of reduced bone strength that predisposes to an increased risk for fractures i …
Bone mineral density gains with a second 12-month course of romosozumab therapy following placebo or denosumab.
Kendler DL, Bone HG, Massari F, Gielen E, Palacios S, Maddox J, Yan C, Yue S, Dinavahi RV, Libanati C, Grauer A. Kendler DL, et al. Osteoporos Int. 2019 Dec;30(12):2437-2448. doi: 10.1007/s00198-019-05146-9. Epub 2019 Oct 18. Osteoporos Int. 2019. PMID: 31628490 Free PMC article. Clinical Trial.
However, for long-term osteoporosis management, a second treatment course may be appropriate. Romosozumab, a therapy with the dual effect of increasing bone formation and decreasing bone resorption, reduces fracture risk within 12 months. ...
However, for long-term osteoporosis management, a second treatment course may be appropriate. Romosozumab, a therapy with the …
Osteoporosis: the evolution of a scientific term.
Schapira D, Schapira C. Schapira D, et al. Osteoporos Int. 1992 Jul;2(4):164-7. doi: 10.1007/BF01623921. Osteoporos Int. 1992. PMID: 1611220 Review.
Coined in French in the early 1820s as a mere description of a pathological state of the bone, the term 'osteoporosis' made its way into the English medical vocabulary only in the twentieth century. ...Even at present, while the 1990 Consensus Conference defi …
Coined in French in the early 1820s as a mere description of a pathological state of the bone, the term 'osteoporosis' …
Efficacy and safety of odanacatib for osteoporosis treatment: a systematic review and meta-analysis.
Chen R, Chen C, Geng B, Yang C, Xiao H, Yang F, Wang H, Xia Y. Chen R, et al. Arch Osteoporos. 2023 May 11;18(1):67. doi: 10.1007/s11657-023-01261-7. Arch Osteoporos. 2023. PMID: 37169994 Review.
PURPOSE: Osteoporosis is a metabolic bone disease that commonly results in middle-aged and elderly people following fractures. ...CONCLUSION: ODN is an appealing long-term osteoporosis treatment method; however, further research should focus on the pot …
PURPOSE: Osteoporosis is a metabolic bone disease that commonly results in middle-aged and elderly people following fractures. …
Western Osteoporosis Alliance Clinical Practice Series: Evaluating the Balance of Benefits and Risks of Long-Term Osteoporosis Therapies.
Hanley DA, McClung MR, Davison KS, Dian L, Harris ST, Miller PD, Lewiecki EM, Kendler DL; Writing Group for the Western Osteoporosis Alliance. Hanley DA, et al. Am J Med. 2017 Jul;130(7):862.e1-862.e7. doi: 10.1016/j.amjmed.2017.03.002. Epub 2017 Mar 27. Am J Med. 2017. PMID: 28359721 Review.
With denosumab, 10 years of therapy appears to provide fracture risk reduction similar to or better than that observed in the 3-year registration trial. Available data suggest an increasing but low risk of fractures with atypical features with increasing duration of …
With denosumab, 10 years of therapy appears to provide fracture risk reduction similar to or better than that observed in the 3-year …
A national study on long-term osteoporosis therapy and risk of recurrent fractures in patients with hip fracture.
Hsu CL, Chen HM, Chen HJ, Chou MY, Wang YC, Hsu YH, Liang CK, Chu CS. Hsu CL, et al. Arch Gerontol Geriatr. 2020 May-Jun;88:104021. doi: 10.1016/j.archger.2020.104021. Epub 2020 Feb 1. Arch Gerontol Geriatr. 2020. PMID: 32058125
OBJECTIVE: The study aimed to evaluate the impact of osteoporosis (OP) medication persistence on subsequent fractures and all-cause mortality in patients with hip fracture. METHODS: In this retrospective cohort study, we included patients aged 40 years with fragilit …
OBJECTIVE: The study aimed to evaluate the impact of osteoporosis (OP) medication persistence on subsequent fractures and all-cause m …
42 results