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The long-term effects of genomic selection: 2. Changes in allele frequencies of causal loci and new mutations.
Wientjes YCJ, Bijma P, van den Heuvel J, Zwaan BJ, Vitezica ZG, Calus MPL. Wientjes YCJ, et al. Among authors: zwaan bj. Genetics. 2023 Aug 31;225(1):iyad141. doi: 10.1093/genetics/iyad141. Genetics. 2023. PMID: 37506255 Free PMC article.
When epistasis was present, the average allele frequency change was smaller (15% lower), and a lower number of loci became fixed for all selection methods. We conclude that for long-term genetic improvement using genomic selection, it is important to consider hitchhiking a …
When epistasis was present, the average allele frequency change was smaller (15% lower), and a lower number of loci became fixed for all sel …
Species dynamics in natural bacterial communities over multiple rounds of propagation.
Groenenboom AE, van den Heuvel J, Zwaan BJ, Smid EJ, Schoustra SE. Groenenboom AE, et al. Among authors: zwaan bj. Evol Appl. 2022 Oct 25;15(11):1766-1775. doi: 10.1111/eva.13470. eCollection 2022 Nov. Evol Appl. 2022. PMID: 36426121 Free PMC article.
Our experimental work illustrates how microbial ecosystems can be shaped by selective pressures over long-term ecological time scales. Natural microbial ecosystems generally consist of various co-existing species, where community composition describes the frequency at whic …
Our experimental work illustrates how microbial ecosystems can be shaped by selective pressures over long-term ecological time scales …
The long-term effects of genomic selection: 1. Response to selection, additive genetic variance, and genetic architecture.
Wientjes YCJ, Bijma P, Calus MPL, Zwaan BJ, Vitezica ZG, van den Heuvel J. Wientjes YCJ, et al. Among authors: zwaan bj. Genet Sel Evol. 2022 Mar 7;54(1):19. doi: 10.1186/s12711-022-00709-7. Genet Sel Evol. 2022. PMID: 35255802 Free PMC article.
BACKGROUND: Genomic selection has revolutionized genetic improvement in animals and plants, but little is known about its long-term effects. Here, we investigated the long-term effects of genomic selection on response to selection, genetic variance, and the genetic …
BACKGROUND: Genomic selection has revolutionized genetic improvement in animals and plants, but little is known about its long-term e …
Dynamics of Aspergillus fumigatus in Azole Fungicide-Containing Plant Waste in the Netherlands (2016-2017).
Zhang J, Lopez Jimenez L, Snelders E, Debets AJM, Rietveld AG, Zwaan BJ, Verweij PE, Schoustra SE. Zhang J, et al. Among authors: zwaan bj. Appl Environ Microbiol. 2021 Jan 4;87(2):e02295-20. doi: 10.1128/AEM.02295-20. Print 2021 Jan 4. Appl Environ Microbiol. 2021. PMID: 33127811 Free PMC article.
Our results show a consistent high burden of azole-resistant A. fumigatus in azole-containing plant waste and underscores the need to further investigate resistance-reducing interventions and transmission routes.IMPORTANCEAspergillus fumigatus is consistently present independentl …
Our results show a consistent high burden of azole-resistant A. fumigatus in azole-containing plant waste and underscores the need to furthe …
Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses.
Kapun M, Barrón MG, Staubach F, Obbard DJ, Wiberg RAW, Vieira J, Goubert C, Rota-Stabelli O, Kankare M, Bogaerts-Márquez M, Haudry A, Waidele L, Kozeretska I, Pasyukova EG, Loeschcke V, Pascual M, Vieira CP, Serga S, Montchamp-Moreau C, Abbott J, Gibert P, Porcelli D, Posnien N, Sánchez-Gracia A, Grath S, Sucena É, Bergland AO, Guerreiro MPG, Onder BS, Argyridou E, Guio L, Schou MF, Deplancke B, Vieira C, Ritchie MG, Zwaan BJ, Tauber E, Orengo DJ, Puerma E, Aguadé M, Schmidt P, Parsch J, Betancourt AJ, Flatt T, González J. Kapun M, et al. Among authors: zwaan bj. Mol Biol Evol. 2020 Sep 1;37(9):2661-2678. doi: 10.1093/molbev/msaa120. Mol Biol Evol. 2020. PMID: 32413142 Free PMC article.
Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatiotemporal patterns of genetic variation in natural populations have been challenging, as comprehensive s …
Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local a …
Phenotypic plasticity and the evolution of azole resistance in Aspergillus fumigatus; an expression profile of clinical isolates upon exposure to itraconazole.
Hokken MWJ, Zoll J, Coolen JPM, Zwaan BJ, Verweij PE, Melchers WJG. Hokken MWJ, et al. Among authors: zwaan bj. BMC Genomics. 2019 Jan 9;20(1):28. doi: 10.1186/s12864-018-5255-z. BMC Genomics. 2019. PMID: 30626317 Free PMC article.
When A. fumigatus is challenged with a new stressful environment, phenotypic plasticity may allow A. fumigatus to adjust their physiology to still enable growth and reproduction, therefore allowing the establishment of genetic adaptations through natural selection on the availabl …
When A. fumigatus is challenged with a new stressful environment, phenotypic plasticity may allow A. fumigatus to adjust their physiology to …
Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments.
Tobi EW, van den Heuvel J, Zwaan BJ, Lumey LH, Heijmans BT, Uller T. Tobi EW, et al. Among authors: zwaan bj. Cell Rep. 2018 Dec 4;25(10):2660-2667.e4. doi: 10.1016/j.celrep.2018.11.023. Cell Rep. 2018. PMID: 30517855 Free article.
An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediated by epigenomic marks, including DNA methylation (DNAm). ...
An adverse intrauterine environment is associated with long-term physiological changes in offspring. These are believed to be mediate …
Strong phenotypic plasticity limits potential for evolutionary responses to climate change.
Oostra V, Saastamoinen M, Zwaan BJ, Wheat CW. Oostra V, et al. Among authors: zwaan bj. Nat Commun. 2018 Mar 8;9(1):1005. doi: 10.1038/s41467-018-03384-9. Nat Commun. 2018. PMID: 29520061 Free PMC article.
Phenotypic plasticity, the expression of multiple phenotypes from one genome, is a widespread adaptation to short-term environmental fluctuations, but whether it facilitates evolutionary adaptation to climate change remains contentious. ...
Phenotypic plasticity, the expression of multiple phenotypes from one genome, is a widespread adaptation to short-term environmental …
Relating past and present diet to phenotypic and transcriptomic variation in the fruit fly.
May CM, Zwaan BJ. May CM, et al. Among authors: zwaan bj. BMC Genomics. 2017 Aug 22;18(1):640. doi: 10.1186/s12864-017-3968-z. BMC Genomics. 2017. PMID: 28830340 Free PMC article.
BACKGROUND: Sub-optimal developmental diets often have adverse effects on long-term fitness and health. One hypothesis is that such effects are caused by mismatches between the developmental and adult environment, and may be mediated by persistent changes in gene expressio …
BACKGROUND: Sub-optimal developmental diets often have adverse effects on long-term fitness and health. One hypothesis is that such e …
Differences in the selection response of serially repeated color pattern characters: standing variation, development, and evolution.
Allen CE, Beldade P, Zwaan BJ, Brakefield PM. Allen CE, et al. Among authors: zwaan bj. BMC Evol Biol. 2008 Mar 26;8:94. doi: 10.1186/1471-2148-8-94. BMC Evol Biol. 2008. PMID: 18366752 Free PMC article.
There was no independent evolutionary change in the color composition of two eyespots in response to antagonistic selection. Moreover, these differences in the directions of short-term evolutionary change in eyespot size and color composition within a single species are co …
There was no independent evolutionary change in the color composition of two eyespots in response to antagonistic selection. Moreover, these …
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