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Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes.
Gimbel BA, Anthony ME, Ernst AM, Roediger DJ, de Water E, Eckerle JK, Boys CJ, Radke JP, Mueller BA, Fuglestad AJ, Zeisel SH, Georgieff MK, Wozniak JR. Gimbel BA, et al. Among authors: zeisel sh. J Neurodev Disord. 2022 Dec 16;14(1):59. doi: 10.1186/s11689-022-09470-w. J Neurodev Disord. 2022. PMID: 36526961 Free PMC article. Clinical Trial.
Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age dur …
Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-t …
Effects of a Novel High-Quality Protein Infant Formula on Energetic Efficiency and Tolerance: A Randomized Trial.
Kuehn D, Zeisel SH, Orenstein DF, German JB, Field CJ, Teerdhala S, Knezevic A, Patil S, Donovan SM, Lönnerdal B. Kuehn D, et al. Among authors: zeisel sh. J Pediatr Gastroenterol Nutr. 2022 Oct 1;75(4):521-528. doi: 10.1097/MPG.0000000000003490. Epub 2022 Jun 6. J Pediatr Gastroenterol Nutr. 2022. PMID: 35666855 Free PMC article. Clinical Trial.
METHODS: This randomized, double-blind trial included healthy, singleton, term infants, enrollment age 14 days. Primary outcome was mean daily weight gain. ...
METHODS: This randomized, double-blind trial included healthy, singleton, term infants, enrollment age 14 days. Primary outcome was m …
Four-year follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder.
Wozniak JR, Fink BA, Fuglestad AJ, Eckerle JK, Boys CJ, Sandness KE, Radke JP, Miller NC, Lindgren C, Brearley AM, Zeisel SH, Georgieff MK. Wozniak JR, et al. Among authors: zeisel sh. J Neurodev Disord. 2020 Mar 12;12(1):9. doi: 10.1186/s11689-020-09312-7. J Neurodev Disord. 2020. PMID: 32164522 Free PMC article. Clinical Trial.
FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windows are emerging. We present a long-term follow-up study evaluating the neurodevelopmental effects of choline supplementation in child …
FASD is often conceptualized as static and permanent, but interventions that capitalize on brain plasticity and critical developmental windo …
Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice.
Prieur EAK, Pjetri E, Zeisel SH, Jadavji NM. Prieur EAK, et al. Among authors: zeisel sh. Appl Physiol Nutr Metab. 2017 Nov;42(11):1228-1231. doi: 10.1139/apnm-2017-0182. Epub 2017 Jul 17. Appl Physiol Nutr Metab. 2017. PMID: 28715642
Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI) volume, as well as impaired reference and short-term memories. The results of this study indicate that the absence of BHMT may play …
Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging (MRI …
Choline supplementation in children with fetal alcohol spectrum disorders: a randomized, double-blind, placebo-controlled trial.
Wozniak JR, Fuglestad AJ, Eckerle JK, Fink BA, Hoecker HL, Boys CJ, Radke JP, Kroupina MG, Miller NC, Brearley AM, Zeisel SH, Georgieff MK. Wozniak JR, et al. Among authors: zeisel sh. Am J Clin Nutr. 2015 Nov;102(5):1113-25. doi: 10.3945/ajcn.114.099168. Epub 2015 Oct 7. Am J Clin Nutr. 2015. PMID: 26447156 Free PMC article. Clinical Trial.
Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial.
Cheatham CL, Goldman BD, Fischer LM, da Costa KA, Reznick JS, Zeisel SH. Cheatham CL, et al. Among authors: zeisel sh. Am J Clin Nutr. 2012 Dec;96(6):1465-72. doi: 10.3945/ajcn.112.037184. Epub 2012 Nov 7. Am J Clin Nutr. 2012. PMID: 23134891 Free PMC article. Clinical Trial.
DESIGN: In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholine (750 mg) or a placebo (corn oil) from 18 wk gestation through 90 d postpartum. Their infants (n = 99) were tested for short-term vi …
DESIGN: In a double-blind, randomized controlled trial, 140 pregnant women were randomly assigned to receive supplemental phosphatidylcholin …
Genetic polymorphisms in methyl-group metabolism and epigenetics: lessons from humans and mouse models.
Zeisel SH. Zeisel SH. Brain Res. 2008 Oct 27;1237:5-11. doi: 10.1016/j.brainres.2008.08.059. Epub 2008 Sep 3. Brain Res. 2008. PMID: 18789905 Free PMC article. Review.
Choline deficiency, through disturbing methyl metabolism, may alter DNA methylation and thereby influence neural precursor cell proliferation and apoptosis. This results in long term alterations in brain structure and function, specifically memory function. ...
Choline deficiency, through disturbing methyl metabolism, may alter DNA methylation and thereby influence neural precursor cell proliferatio …
Gene response elements, genetic polymorphisms and epigenetics influence the human dietary requirement for choline.
Zeisel SH. Zeisel SH. IUBMB Life. 2007 Jun;59(6):380-7. doi: 10.1080/15216540701468954. IUBMB Life. 2007. PMID: 17613168 Free PMC article. Review.
Choline is critical during fetal development, when it alters DNA methylation and thereby influences neural precursor cell proliferation and apoptosis. This results in long term alterations in brain structure and function, specifically memory function....
Choline is critical during fetal development, when it alters DNA methylation and thereby influences neural precursor cell proliferation and …
Choline deficiency induces apoptosis and decreases the number of eosinophilic preneoplastic foci in the liver of OXYS rats.
Albright CD, Zeisel SH, Salganik RI. Albright CD, et al. Among authors: zeisel sh. Pathobiology. 1998;66(2):71-6. doi: 10.1159/000027999. Pathobiology. 1998. PMID: 9645630
Choline deficiency (CD) was previously shown to trigger apoptosis in rat hepatocytes in culture and in vivo. In the present study we investigated the effects of short-term withdrawal of choline from the diet on the expression of putative preneoplastic foci in OXYS rats, an …
Choline deficiency (CD) was previously shown to trigger apoptosis in rat hepatocytes in culture and in vivo. In the present study we investi …
Choline availability modulates the expression of TGFbeta1 and cytoskeletal proteins in the hippocampus of developing rat brain.
Albright CD, Tsai AY, Mar MH, Zeisel SH. Albright CD, et al. Among authors: zeisel sh. Neurochem Res. 1998 May;23(5):751-8. doi: 10.1023/a:1022411510636. Neurochem Res. 1998. PMID: 9566615
Choline availability influences long-term memory in concert with changes in the spatial organization and morphology of septal neurons, however little is known concerning the effects of choline on the hippocampus, a region of the brain also important for memory performance. …
Choline availability influences long-term memory in concert with changes in the spatial organization and morphology of septal neurons …
18 results