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In vivo generation of beta-cell-like cells from CD34(+) cells differentiated from human embryonic stem cells.
Goodrich AD, Ersek A, Varain NM, Groza D, Cenariu M, Thain DS, Almeida-Porada G, Porada CD, Zanjani ED. Goodrich AD, et al. Among authors: zanjani ed. Exp Hematol. 2010 Jun;38(6):516-525.e4. doi: 10.1016/j.exphem.2010.03.002. Epub 2010 Mar 12. Exp Hematol. 2010. PMID: 20227460 Free PMC article.
An average of 1.51 ng/mL human C-peptide was detected in serum from eight animals transplanted with differentiated cell populations and assayed up to 55 months posttransplantation. Transplantation of as few as 23,500 cells resulted in long-term sustainable beta-cell-like a …
An average of 1.51 ng/mL human C-peptide was detected in serum from eight animals transplanted with differentiated cell populations and assa …
Immune ontogeny and engraftment receptivity in the sheep fetus.
Skopal-Chase JL, Pixley JS, Torabi A, Cenariu MC, Bhat A, Thain DS, Frederick NM, Groza DM, Zanjani ED. Skopal-Chase JL, et al. Among authors: zanjani ed. Fetal Diagn Ther. 2009;25(1):102-10. doi: 10.1159/000203399. Epub 2009 Feb 25. Fetal Diagn Ther. 2009. PMID: 19246928 Free PMC article.
OBJECTIVE: The biologic explanation for fetal receptivity to donor engraftment and subsequent long-term tolerance following transplantation early in gestation is not known. ...RESULTS: An engraftment window was identified after day 52 gestation lasting until day 71 (ter …
OBJECTIVE: The biologic explanation for fetal receptivity to donor engraftment and subsequent long-term tolerance following transplan …
A Stro-1(+) human universal stromal feeder layer to expand/maintain human bone marrow hematopoietic stem/progenitor cells in a serum-free culture system.
Gonçalves R, Lobato da Silva C, Cabral JM, Zanjani ED, Almeida-Porada G. Gonçalves R, et al. Among authors: zanjani ed. Exp Hematol. 2006 Oct;34(10):1353-9. doi: 10.1016/j.exphem.2006.05.024. Exp Hematol. 2006. PMID: 16982328 Free article.
Furthermore, we compared the results obtained with MSC as a feeder layer to traditional allogeneic stromal layers grown in long-term bone marrow culture media (LT-ST). METHODS: Adult human bone marrow CD34(+)-enriched cells were cultured in serum-free medium for 2 to 3 wee …
Furthermore, we compared the results obtained with MSC as a feeder layer to traditional allogeneic stromal layers grown in long-term …
Human embryonic stem cell-derived hematopoietic cells are capable of engrafting primary as well as secondary fetal sheep recipients.
Narayan AD, Chase JL, Lewis RL, Tian X, Kaufman DS, Thomson JA, Zanjani ED. Narayan AD, et al. Among authors: zanjani ed. Blood. 2006 Mar 1;107(5):2180-3. doi: 10.1182/blood-2005-05-1922. Epub 2005 Nov 8. Blood. 2006. PMID: 16278307 Free PMC article.
We therefore conclude that hESCs are capable of generating hematopoietic cells that engraft primary recipients. These cells also fulfill the criteria for long-term engrafting hematopoietic stem cells as demonstrated by engraftment and differentiation in the secondary recip …
We therefore conclude that hESCs are capable of generating hematopoietic cells that engraft primary recipients. These cells also fulfill the …
In vivo haematopoietic potential of human neural stem cells.
Almeida-Porada G, Crapnell K, Porada C, Benoit B, Nakauchi H, Quesenberry P, Zanjani ED. Almeida-Porada G, et al. Among authors: zanjani ed. Br J Haematol. 2005 Jul;130(2):276-83. doi: 10.1111/j.1365-2141.2005.05588.x. Br J Haematol. 2005. PMID: 16029457 Free article.
Transplantation of secondary recipients with human CD45(+)/HLA-DR(+) cells from the BM of NSC primary recipients at 14 and 16 months post-transplant demonstrated that long-term engrafting HSC were present in these animals. At 6 months post-transplant, both NSC- and HSC-tra …
Transplantation of secondary recipients with human CD45(+)/HLA-DR(+) cells from the BM of NSC primary recipients at 14 and 16 months post-tr …
The fetal sheep: a unique model system for assessing the full differentiative potential of human stem cells.
Porada GA, Porada C, Zanjani ED. Porada GA, et al. Among authors: zanjani ed. Yonsei Med J. 2004 Jun 30;45 Suppl:7-14. doi: 10.3349/ymj.2004.45.Suppl.7. Yonsei Med J. 2004. PMID: 15250043 Free article. Review.
These characteristics combined with the relative immunological naivete of the early gestational age fetus that permits the engraftment and long-term persistence of allogeneic and xenogeneic donor stem cells make it possible to use the developing fetus to assess the in vivo …
These characteristics combined with the relative immunological naivete of the early gestational age fetus that permits the engraftment and l …
Human haematopoietic stem cells that mediate long-term in vivo engraftment are not susceptible to infection by human cytomegalovirus.
Crapnell KB, Almeida-Porada G, Khaiboullina S, St Jeor SC, Zanjani ED. Crapnell KB, et al. Among authors: zanjani ed. Br J Haematol. 2004 Mar;124(5):676-84. doi: 10.1111/j.1365-2141.2004.04827.x. Br J Haematol. 2004. PMID: 14871256 Free article.
A human/sheep xenograft model was used to evaluate whether long-term engrafting haematopoietic stem cells (HSC) are susceptible to human cytomegalovirus (HCMV) infection. ...At 5 weeks post-transplant several organs were HLA-DQalpha- and HCMV-positive, confirming that HCMV …
A human/sheep xenograft model was used to evaluate whether long-term engrafting haematopoietic stem cells (HSC) are susceptible to hu …
The sheep model of in utero gene therapy.
Porada CD, Park P, Almeida-Porada G, Zanjani ED. Porada CD, et al. Among authors: zanjani ed. Fetal Diagn Ther. 2004 Jan-Feb;19(1):23-30. doi: 10.1159/000074255. Fetal Diagn Ther. 2004. PMID: 14646413 Review.
Performing GT in utero would allow early correction prior to disease onset and is thus one of the few therapeutic modalities that could promise the birth of a healthy infant. Several features of the developing fetus may circumvent obstacles that have thus far been observed …
Performing GT in utero would allow early correction prior to disease onset and is thus one of the few therapeutic modalities that could prom …
Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells.
Zanjani ED, Almeida-Porada G, Livingston AG, Zeng H, Ogawa M. Zanjani ED, et al. Exp Hematol. 2003 May;31(5):406-12. doi: 10.1016/s0301-472x(03)00051-1. Exp Hematol. 2003. PMID: 12763139 Free article.
We also reported on the reversibility of CD34 expression by murine hematopoietic stem cells. Based on long-term observations in primary, secondary, and tertiary sheep recipients, we now present definitive evidence for the long-term engrafting capability of human BM …
We also reported on the reversibility of CD34 expression by murine hematopoietic stem cells. Based on long-term observations in prima …
Differentiative potential of human metanephric mesenchymal cells.
Almeida-Porada G, El Shabrawy D, Porada C, Zanjani ED. Almeida-Porada G, et al. Among authors: zanjani ed. Exp Hematol. 2002 Dec;30(12):1454-62. doi: 10.1016/s0301-472x(02)00967-0. Exp Hematol. 2002. PMID: 12482508 Free article.
Successful hematopoietic engraftment in secondary recipients demonstrated the generation of long-term engrafting hematopoietic stem cells from MNMC. PCR analysis confirmed human hematopoietic engraftment and revealed that human cells were also present within other organs. …
Successful hematopoietic engraftment in secondary recipients demonstrated the generation of long-term engrafting hematopoietic stem c …
47 results