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Burden of Disease in Patients With Tumor-Induced Osteomalacia.
Jerkovich F, Nuñez S, Mocarbel Y, Pignatta A, Elías N, Cassinelli H, Díaz AG, Vigovich C, Balonga MC, Cohen AC, Mumbach G, Gonzalez S, Zanchetta JR, Zanchetta MB. Jerkovich F, et al. Among authors: zanchetta jr. JBMR Plus. 2020 Dec 18;5(2):e10436. doi: 10.1002/jbm4.10436. eCollection 2021 Feb. JBMR Plus. 2020. PMID: 33615105 Free PMC article.
Tumor-induced osteomalacia (TIO) is a chronic condition associated with muscle weakness and long-term disability. We conducted a cross-sectional study of patients diagnosed with TIO who had been referred to our institution between May 2018 and December 2019. ...
Tumor-induced osteomalacia (TIO) is a chronic condition associated with muscle weakness and long-term disability. We conducted a cros …
Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study.
McClung MR, O'Donoghue ML, Papapoulos SE, Bone H, Langdahl B, Saag KG, Reid IR, Kiel DP, Cavallari I, Bonaca MP, Wiviott SD, de Villiers T, Ling X, Lippuner K, Nakamura T, Reginster JY, Rodriguez-Portales JA, Roux C, Zanchetta J, Zerbini CAF, Park JG, Im K, Cange A, Grip LT, Heyden N, DaSilva C, Cohn D, Massaad R, Scott BB, Verbruggen N, Gurner D, Miller DL, Blair ML, Polis AB, Stoch SA, Santora A, Lombardi A, Leung AT, Kaufman KD, Sabatine MS; LOFT Investigators. McClung MR, et al. Lancet Diabetes Endocrinol. 2019 Dec;7(12):899-911. doi: 10.1016/S2213-8587(19)30346-8. Epub 2019 Oct 31. Lancet Diabetes Endocrinol. 2019. PMID: 31676222 Clinical Trial.
We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. METHODS: The Long-term Odanacatib Fracture Trial (LOFT) was a multicentre, randomised, double-blind, placebo-controlled, event-driven study at 3 …
We aimed to investigate the efficacy and safety of odanacatib to reduce fracture risk in postmenopausal women with osteoporosis. METHODS: Th …
Significant bone loss after stopping long-term denosumab treatment: a post FREEDOM study.
Zanchetta MB, Boailchuk J, Massari F, Silveira F, Bogado C, Zanchetta JR. Zanchetta MB, et al. Among authors: zanchetta jr. Osteoporos Int. 2018 Jan;29(1):41-47. doi: 10.1007/s00198-017-4242-6. Epub 2017 Oct 3. Osteoporos Int. 2018. PMID: 28975362
We evaluate 38 elderly women who had received long-term denosumab treatment after stopping the drug. Taking into account the gain during treatment and the loss after stopping treatment, they lost 35.5% of the total gain in the spine, 44.6% of the total gain in the femoral …
We evaluate 38 elderly women who had received long-term denosumab treatment after stopping the drug. Taking into account the gain dur …
Assessment of bone microarchitecture in postmenopausal women on long-term bisphosphonate therapy with atypical fractures of the femur.
Zanchetta MB, Diehl M, Buttazzoni M, Galich A, Silveira F, Bogado CE, Zanchetta JR. Zanchetta MB, et al. Among authors: zanchetta jr. J Bone Miner Res. 2014 Apr;29(4):999-1004. doi: 10.1002/jbmr.2107. J Bone Miner Res. 2014. PMID: 24115250 Free article.
Reports of atypical femoral fractures (AFFs) in patients receiving long- term bisphosphonate therapy have raised concerns regarding the genesis of this rare event. ...We compared bone volumetric density and microarchitectural parameters measured by HR-pQCT in the radius an …
Reports of atypical femoral fractures (AFFs) in patients receiving long- term bisphosphonate therapy have raised concerns regarding t …
Treatment of postmenopausal women with osteoporosis with PTH(1-84) for 36 months: treatment extension study.
Zanchetta JR, Bogado CE, Cisari C, Aslanidis S, Greisen H, Fox J, Lems W. Zanchetta JR, et al. Curr Med Res Opin. 2010 Nov;26(11):2627-33. doi: 10.1185/03007995.2010.524121. Epub 2010 Oct 5. Curr Med Res Opin. 2010. PMID: 20923256 Clinical Trial.
BACKGROUND: The TOP trial demonstrated increased lumbar spine BMD (6.9%) versus placebo after 18 months of PTH(1-84) treatment and reduced the incidence of new vertebral fractures (61%; p = 0.001). The therapeutic benefits of long-term treatment of postmenopausal women wit …
BACKGROUND: The TOP trial demonstrated increased lumbar spine BMD (6.9%) versus placebo after 18 months of PTH(1-84) treatment and reduced t …
Lean mass estimation by creatinine kinetics and dual-energy x-ray absorptiometry in peritoneal dialysis.
Negri AL, Barone R, Veron D, Fraga A, Arrizurieta E, Zucchini A, Zanchetta JR. Negri AL, et al. Among authors: zanchetta jr. Nephron Clin Pract. 2003;95(1):c9-14. doi: 10.1159/000073013. Nephron Clin Pract. 2003. PMID: 14520016
AIMS: (1) To assess the reliability of lean mass measurements obtained by creatinine kinetics (CrK) in a group of stable peritoneal dialysis (PD) patients, using dual-energy x-ray absorptiometry (DEXA) measurements as the reference method; (2) to establish the reproducibility of …
AIMS: (1) To assess the reliability of lean mass measurements obtained by creatinine kinetics (CrK) in a group of stable peritoneal dialysis …
[Tolerability of oral bisphosponates in patients with osteoporosis and other osteopathies].
Spivacow R, Roldán EJ, Zanetti D, Piccinni E, Zanchetta JR. Spivacow R, et al. Among authors: zanchetta jr. Medicina (B Aires). 1997;57 Suppl 1:114-8. Medicina (B Aires). 1997. PMID: 9567364 Spanish.
Notwithstanding, some digestive disturbances create concern on the long term acceptance of the oral route. Side effects are mainly caused by low absorption and poor solubility in digestive content. ...The current clinical published data shows more or less the same safety p …
Notwithstanding, some digestive disturbances create concern on the long term acceptance of the oral route. Side effects are mainly ca …
Mineral density gain in vertebrae of osteoporotic women on oral pamidronate reverts a year after treatment discontinuance.
Zanchetta JR, Plotkin H, Roldán EJ. Zanchetta JR, et al. Calcif Tissue Int. 1996 Jul;59(1):70-2. doi: 10.1007/s002239900088. Calcif Tissue Int. 1996. PMID: 8661988
Long-term treatment with 200 mg dry weight/day of pamidronate (APD) by oral route has been proposed to increase bone mineral density (BMD) in postmenopausal osteoporotic women. ...
Long-term treatment with 200 mg dry weight/day of pamidronate (APD) by oral route has been proposed to increase bone mineral density …
Monophasic dose-response curves of betamethasone on geometric and mechanical properties of femur diaphyses in growing rats.
Ferretti JL, Capozza RF, Cointry GR, Delgado CJ, Zanchetta JR. Ferretti JL, et al. Among authors: zanchetta jr. Bone. 1995 Jan;16(1):103-8. doi: 10.1016/s8756-3282(94)00016-6. Bone. 1995. PMID: 7742067
The biomechanical repercussion of the corticoid-induced osteopenia (a severe consequence of long-term glucocorticoid therapy) was studied in cortical bone of small rodents. ...
The biomechanical repercussion of the corticoid-induced osteopenia (a severe consequence of long-term glucocorticoid therapy) was stu …
Effect of low doses of deflazacort vs prednisone on bone mineral content in premenopausal rheumatoid arthritis.
Messina OD, Barreira JC, Zanchetta JR, Maldonado-Cocco JA, Bogado CE, Sebastián ON, Flores D, Riopedre AM, Redondo G, Lázaro A. Messina OD, et al. Among authors: zanchetta jr. J Rheumatol. 1992 Oct;19(10):1520-6. J Rheumatol. 1992. PMID: 1464862 Clinical Trial.
We believe this is the first study on corticosteroid induced osteoporosis, as evaluated by whole body mineral content measurements in premenopausal patients with short term RA, showing that deflazacort is a promising alternative in cases severe enough to require steroid th …
We believe this is the first study on corticosteroid induced osteoporosis, as evaluated by whole body mineral content measurements in premen …
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