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Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection.
Cho JL, Villacreses R, Nagpal P, Guo J, Pezzulo AA, Thurman AL, Hamzeh NY, Blount RJ, Fortis S, Hoffman EA, Zabner J, Comellas AP. Cho JL, et al. Among authors: zabner j. Radiology. 2022 Jul;304(1):185-192. doi: 10.1148/radiol.212170. Epub 2022 Mar 15. Radiology. 2022. PMID: 35289657 Free PMC article.
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Conclusion In survivors of COVID-19, small airways disease occurred independently of initial infection severity. The long-term conseque …
Background The long-term effects of SARS-CoV-2 infection on pulmonary structure and function remain incompletely characterized. ...Co …
Randomized controlled study of aerosolized hypertonic xylitol versus hypertonic saline in hospitalized patients with pulmonary exacerbation of cystic fibrosis.
Singh S, Hornick D, Fedler J, Launspach JL, Teresi ME, Santacroce TR, Cavanaugh JE, Horan R, Nelson G, Starner TD, Zabner J, Durairaj L. Singh S, et al. Among authors: zabner j. J Cyst Fibros. 2020 Jan;19(1):108-113. doi: 10.1016/j.jcf.2019.06.016. Epub 2019 Jul 18. J Cyst Fibros. 2020. PMID: 31327670 Free PMC article. Clinical Trial.
CONCLUSIONS: Aerosolized hypertonic xylitol was well-tolerated among subjects hospitalized for CF pulmonary exacerbation. Future studies examining efficacy for long term use in patients with CF lung disease would be worthwhile. The clinical trial registration number for th …
CONCLUSIONS: Aerosolized hypertonic xylitol was well-tolerated among subjects hospitalized for CF pulmonary exacerbation. Future studies exa …
A Novel AAV-mediated Gene Delivery System Corrects CFTR Function in Pigs.
Cooney AL, Thornell IM, Singh BK, Shah VS, Stoltz DA, McCray PB Jr, Zabner J, Sinn PL. Cooney AL, et al. Among authors: zabner j. Am J Respir Cell Mol Biol. 2019 Dec;61(6):747-754. doi: 10.1165/rcmb.2019-0006OC. Am J Respir Cell Mol Biol. 2019. PMID: 31184507 Free PMC article.
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR cDNA cargo. In this short-term study, PB/AAV-CFTR was aerosolized to the airways of CF pigs in the absence of the transposase. ...
Because of the packaging constraints of AAV, careful consideration was required to ensure that the vector would package and express its CFTR …
Safety assessment of inhaled xylitol in subjects with cystic fibrosis.
Durairaj L, Launspach J, Watt JL, Mohamad Z, Kline J, Zabner J. Durairaj L, et al. Among authors: zabner j. J Cyst Fibros. 2007 Jan;6(1):31-4. doi: 10.1016/j.jcf.2006.05.002. Epub 2006 Jun 15. J Cyst Fibros. 2007. PMID: 16781897 Free article. Clinical Trial.
CONCLUSIONS: A single dose inhalation of aerosolized iso-osmotic xylitol was well tolerated by subjects with cystic fibrosis. Future studies of long term safety are required....
CONCLUSIONS: A single dose inhalation of aerosolized iso-osmotic xylitol was well tolerated by subjects with cystic fibrosis. Future studies …
Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors.
Keriel A, René C, Galer C, Zabner J, Kremer EJ. Keriel A, et al. Among authors: zabner j. J Virol. 2006 Feb;80(3):1487-96. doi: 10.1128/JVI.80.3.1487-1496.2006. J Virol. 2006. PMID: 16415025 Free PMC article.
Our data suggest that CAV-2 vectors may be efficient and safe tools for long-term clinical gene transfer to the respiratory tract....
Our data suggest that CAV-2 vectors may be efficient and safe tools for long-term clinical gene transfer to the respiratory tract....
Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.
Zhang LN, Karp P, Gerard CJ, Pastor E, Laux D, Munson K, Yan Z, Liu X, Godwin S, Thomas CP, Zabner J, Shi H, Caldwell CW, Peluso R, Carter B, Engelhardt JF. Zhang LN, et al. Among authors: zabner j. Mol Ther. 2004 Dec;10(6):990-1002. doi: 10.1016/j.ymthe.2004.08.009. Mol Ther. 2004. PMID: 15564131 Free article.
Treatment of human CF airway epithelia with proteasome modulating agents (LLnL and doxorubicin) at the time of rAAV2 or rAAV2/5 infection dramatically enhanced CFTR gene delivery and correction of CFTR-mediated short-circuit currents. Surprisingly, these agents also facilitated l …
Treatment of human CF airway epithelia with proteasome modulating agents (LLnL and doxorubicin) at the time of rAAV2 or rAAV2/5 infection dr …
E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors.
Armentano D, Smith MP, Sookdeo CC, Zabner J, Perricone MA, St George JA, Wadsworth SC, Gregory RJ. Armentano D, et al. Among authors: zabner j. J Virol. 1999 Aug;73(8):7031-4. doi: 10.1128/JVI.73.8.7031-7034.1999. J Virol. 1999. PMID: 10400804 Free PMC article.
Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistenc …
Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was …
Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.
Zabner J, Couture LA, Gregory RJ, Graham SM, Smith AE, Welsh MJ. Zabner J, et al. Cell. 1993 Oct 22;75(2):207-16. doi: 10.1016/0092-8674(93)80063-k. Cell. 1993. PMID: 7691415
We found no evidence of viral replication or virus-associated adverse effects, even at the highest dose tested (25 MOI). These data represent a small step in achieving long-term improvement of CF lung function by gene therapy....
We found no evidence of viral replication or virus-associated adverse effects, even at the highest dose tested (25 MOI). These data represen …