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Musculoskeletal and neurocognitive clinical significance of adult hypophosphatasia.
Kim SM, Korkmaz F, Sims S, Ryu V, Yuen T, Zaidi M. Kim SM, et al. Among authors: yuen t. Osteoporos Sarcopenia. 2023 Dec;9(4):115-120. doi: 10.1016/j.afos.2023.12.003. Epub 2023 Dec 20. Osteoporos Sarcopenia. 2023. PMID: 38374822 Free PMC article. Review.
Doctor Rathbun first described the case of a 3-week-old infant who presented with severe osteopenia, rickets, and multiple radiographic fractures, and died shortly after of epileptic seizure and respiratory distress. The term "hypophosphatasia" was coined as the patients' …
Doctor Rathbun first described the case of a 3-week-old infant who presented with severe osteopenia, rickets, and multiple radiographic frac …
Development and biophysical characterization of a humanized FSH-blocking monoclonal antibody therapeutic formulated at an ultra-high concentration.
Rojekar S, Pallapati AR, Gimenez-Roig J, Korkmaz F, Sultana F, Sant D, Haeck CM, Macdonald A, Kim SM, Rosen CJ, Barak O, Meseck M, Caminis J, Lizneva D, Yuen T, Zaidi M. Rojekar S, et al. Among authors: yuen t. Elife. 2023 Jun 19;12:e88898. doi: 10.7554/eLife.88898. Elife. 2023. PMID: 37334968 Free PMC article.
The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation's long-term colloidal and thermal stability. Thermal stability was further confirmed by Nano differential scanning calorimetry (DSC). ...
The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation's long-term colloidal and the …
Development and Biophysical Characterization of a Humanized FSH-Blocking Monoclonal Antibody Therapeutic Formulated at an Ultra-High Concentration.
Rojekar S, Pallapati AR, Gimenez-Roig J, Korkmaz F, Sultana F, Sant D, Haeck C, Macdonald A, Kim SM, Rosen CJ, Barak O, Meseck M, Caminis J, Lizneva D, Yuen T, Zaidi M. Rojekar S, et al. Among authors: yuen t. bioRxiv [Preprint]. 2023 May 11:2023.05.11.540323. doi: 10.1101/2023.05.11.540323. bioRxiv. 2023. PMID: 37214886 Free PMC article. Updated. Preprint.
The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation's long-term colloidal and thermal stability. Thermal stability was further confirmed by Nano differential scanning calorimetry (DSC). ...
The addition of the antioxidant L-methionine and chelating agent disodium EDTA improved the formulation's long-term colloidal and the …
Comparing the Effectiveness of 2 Cardiac Rehabilitation Exercise Therapy Programs.
Yuen T, Buijs DM, Hong Y, Van Damme A, Meyer TC, Nagendran J, Gyenes GT. Yuen T, et al. CJC Open. 2022 Dec 6;5(3):215-219. doi: 10.1016/j.cjco.2022.11.022. eCollection 2023 Mar. CJC Open. 2022. PMID: 37013075 Free PMC article.
The results of this study may have implications for evaluating how to minimize barriers to both rehabilitation participation and long-term effectiveness of CR programs. The results may help inform the structuring and funding of future rehabilitation programs....
The results of this study may have implications for evaluating how to minimize barriers to both rehabilitation participation and long-ter …
Post-radiation primary hypothyroidism in patients with head and neck cancer: External validation of thyroid gland dose-volume constraints with long-term endocrine outcomes.
Chow JCH, Lui JCF, Cheung KM, Tam AHP, Lam MHC, Yuen TYS, Lee FKH, Leung AKC, Au KH, Ng WT, Lee AWM, Kwan CK, Yiu HHY. Chow JCH, et al. Among authors: yuen tys. Radiother Oncol. 2022 Dec;177:105-110. doi: 10.1016/j.radonc.2022.10.034. Epub 2022 Nov 3. Radiother Oncol. 2022. PMID: 36336109
No radiation dose-volume constraint of the thyroid gland has been externally validated for predicting long-term thyroid function outcomes. MATERIALS AND METHODS: This external validation study evaluated the diagnostic properties of 22 radiation dose-volume constraints of t …
No radiation dose-volume constraint of the thyroid gland has been externally validated for predicting long-term thyroid function outc …
Congenital Adrenal Hyperplasia.
Yau M, Khattab A, Yuen T, New M. Yau M, et al. Among authors: yuen t. 2022 Nov 3. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. 2022 Nov 3. In: Feingold KR, Anawalt B, Blackman MR, Boyce A, Chrousos G, Corpas E, de Herder WW, Dhatariya K, Dungan K, Hofland J, Kalra S, Kaltsas G, Kapoor N, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, New M, Purnell J, Sahay R, Shah AS, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–. PMID: 25905188 Free Books & Documents. Review.
Congenital Adrenal Hyperplasia (CAH) is a term used to describe a group of genetically determined disorders of defective steroidogenesis that result in variable deficiency of the end products cortisol and/or aldosterone and their deleterious, including life-threatening, ef …
Congenital Adrenal Hyperplasia (CAH) is a term used to describe a group of genetically determined disorders of defective steroidogene …
SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.
Qiao W, Lau HE, Xie H, Poon VK, Chan CC, Chu H, Yuan S, Yuen TT, Chik KK, Tsang JO, Chan CC, Cai JP, Luo C, Yuen KY, Cheung KM, Chan JF, Yeung KW. Qiao W, et al. Among authors: yuen tt. Nat Commun. 2022 May 9;13(1):2539. doi: 10.1038/s41467-022-30195-w. Nat Commun. 2022. PMID: 35534483 Free PMC article.
Our findings suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone …
Our findings suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the lon …
Structured re-training to reduce peritonitis in a pediatric peritoneal dialysis program: a quality improvement intervention.
Teo S, Yuen TW, Cheong CW, Rahman MA, Bhandari N, Hussain NH, Mistam H, Geng J, Goh CY, Than M, Chan YH, Yap HK, Ng KH. Teo S, et al. Among authors: yuen tw. Pediatr Nephrol. 2021 Oct;36(10):3191-3200. doi: 10.1007/s00467-021-05039-2. Epub 2021 Apr 2. Pediatr Nephrol. 2021. PMID: 33797581
METHODS: This is a prospective quality improvement study involving pediatric patients on long-term home automated PD at National University Hospital, Singapore, between 2012 and 2018. ...
METHODS: This is a prospective quality improvement study involving pediatric patients on long-term home automated PD at National Univ …
The NO-cGMP-PKG pathway in skeletal remodeling.
Kim SM, Yuen T, Iqbal J, Rubin MR, Zaidi M. Kim SM, et al. Among authors: yuen t. Ann N Y Acad Sci. 2021 Mar;1487(1):21-30. doi: 10.1111/nyas.14486. Epub 2020 Aug 28. Ann N Y Acad Sci. 2021. PMID: 32860248 Free PMC article. Review.
However, the off-target effects and tachyphylaxis of NO limit its long-term use, and previous clinical trials using organic nitrates for osteoporosis have been disappointing. ...
However, the off-target effects and tachyphylaxis of NO limit its long-term use, and previous clinical trials using organic nitrates …
Is establishing a specialist back pain assessment and management service in primary care a safe and effective model? Twelve-month results from the Back pain Assessment Clinic (BAC) prospective cohort pilot study.
Moi JHY, Phan U, de Gruchy A, Liew D, Yuen TI, Cunningham JE, Wicks IP. Moi JHY, et al. Among authors: yuen ti. BMJ Open. 2018 Oct 10;8(10):e019275. doi: 10.1136/bmjopen-2017-019275. BMJ Open. 2018. PMID: 30309987 Free PMC article.
Results of the BAC pilot merit further evaluation to determine the potential cost-effectiveness, longer term and broader societal impact of implementing BAC more widely....
Results of the BAC pilot merit further evaluation to determine the potential cost-effectiveness, longer term and broader societal imp …
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