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Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE; GRADE Research Group. Rasouli N, et al. Among authors: younes n. Diabetes Care. 2024 Apr 1;47(4):580-588. doi: 10.2337/dc23-1070. Diabetes Care. 2024. PMID: 38211595 Clinical Trial.
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and sitagliptin) when added to metformin on insulin sensitivity and beta-cell function. ...After adjustment for HOMA2-%S to obtain an estimate of …
OBJECTIVE: To compare the long-term effects of glucose-lowering medications (insulin glargine U-100, glimepiride, liraglutide, and si …
Impact of Insulin Sensitivity and β-Cell Function Over Time on Glycemic Outcomes in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE): Differential Treatment Effects of Dual Therapy.
Utzschneider KM, Younes N, Butera NM, Balasubramanyam A, Bergenstal RM, Barzilay J, DeSouza C, DeFronzo RA, Elasy T, Krakoff J, Kahn SE, Rasouli N, Valencia WM, Sivitz WI; GRADE Research Group. Utzschneider KM, et al. Among authors: younes n. Diabetes Care. 2024 Apr 1;47(4):571-579. doi: 10.2337/dc23-1059. Diabetes Care. 2024. PMID: 38190619 Clinical Trial.
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in the sitagliptin group on initial (short-term) HbA1c response in comparison with the glimepiride and liraglutide groups....
CONCLUSIONS: Insulin sensitivity and beta-cell function affected treatment outcomes irrespective of drug assignment, with greater impact in …
Performance Evaluation of a New Fluorescent-Based Lateral Flow Immunoassay for Quantification of Hemoglobin A1c (HBA1c) in Diabetic Patients.
Younes N, Ghwairi MMA, Da'as SI, Zaabi EA, Majdalawieh AF, Al-Dewik N, Nasrallah GK. Younes N, et al. Front Biosci (Landmark Ed). 2023 Mar 23;28(3):60. doi: 10.31083/j.fbl2803060. Front Biosci (Landmark Ed). 2023. PMID: 37005766 Free article.
CONCLUSIONS: Finecare is a reliable and rapid assay (5 min) which can be easily implemented for long-term monitoring of HbA1c in diabetic patients, particularly in small laboratory settings....
CONCLUSIONS: Finecare is a reliable and rapid assay (5 min) which can be easily implemented for long-term monitoring of HbA1c in diab …
"Safe" Chitosan/Zinc Oxide Nanocomposite Has Minimal Organ-Specific Toxicity in Early Stages of Zebrafish Development.
Younes N, Pintus G, Al-Asmakh M, Rasool K, Younes S, Calzolari S, Mahmoud KA, Nasrallah GK. Younes N, et al. ACS Biomater Sci Eng. 2020 Jan 13;6(1):38-47. doi: 10.1021/acsbiomaterials.8b01144. Epub 2019 Mar 5. ACS Biomater Sci Eng. 2020. PMID: 33463193
However, the observed hepatotoxicity had no effect on embryo survival even after long-term (10-days) exposure to CZNCs. We believe our results add valuable information to the potential toxicity of chitosan/metal oxide nanocomposites, which may provide new insights into the …
However, the observed hepatotoxicity had no effect on embryo survival even after long-term (10-days) exposure to CZNCs. We believe ou …
Potential Adverse Effects of Resveratrol: A Literature Review.
Shaito A, Posadino AM, Younes N, Hasan H, Halabi S, Alhababi D, Al-Mohannadi A, Abdel-Rahman WM, Eid AH, Nasrallah GK, Pintus G. Shaito A, et al. Among authors: younes n. Int J Mol Sci. 2020 Mar 18;21(6):2084. doi: 10.3390/ijms21062084. Int J Mol Sci. 2020. PMID: 32197410 Free PMC article. Review.
Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. ...
Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term …
Long-term occupational trajectories and suicide: a 22-year follow-up of the GAZEL cohort study.
Azevedo Da Silva M, Younès N, Leroyer A, Plancke L, Lemogne C, Goldberg M, Rivière M, Melchior M. Azevedo Da Silva M, et al. Among authors: younes n. Scand J Work Environ Health. 2019 Mar 1;45(2):158-165. doi: 10.5271/sjweh.3767. Epub 2018 Sep 16. Scand J Work Environ Health. 2019. PMID: 30221652 Free article.
Risk is elevated in some occupational groups, however relations between long-term occupational trajectories and suicide are not well known. We describe career-long occupational trajectories and examine their influence on suicide. ...
Risk is elevated in some occupational groups, however relations between long-term occupational trajectories and suicide are not well …
Recovery of steroid induced adrenal insufficiency.
Younes AK, Younes NK. Younes AK, et al. Among authors: younes nk. Transl Pediatr. 2017 Oct;6(4):269-273. doi: 10.21037/tp.2017.10.01. Transl Pediatr. 2017. PMID: 29184808 Free PMC article. Review.
This can be caused by hypopituitarism, central nervous system injury (tumors, radiation, and surgery) or long-term glucocorticoid therapy. Glucocorticoids were introduced in the 1950s, and have been used for their anti-inflammatory and other pharmacological effects, and al …
This can be caused by hypopituitarism, central nervous system injury (tumors, radiation, and surgery) or long-term glucocorticoid the …
The changing psychology of culture in German-speaking countries: A Google Ngram study.
Younes N, Reips UD. Younes N, et al. Int J Psychol. 2018 Oct;53 Suppl 1:53-62. doi: 10.1002/ijop.12428. Epub 2017 May 5. Int J Psychol. 2018. PMID: 28474338
This article provides evidence for the long-term affiliation between ecological and cultural changes in German-speaking countries, based on the assumptions derived from social change and human development theory. ...
This article provides evidence for the long-term affiliation between ecological and cultural changes in German-speaking countries, ba …
Cancer-specific mortality, cure fraction, and noncancer causes of death among diffuse large B-cell lymphoma patients in the immunochemotherapy era.
Howlader N, Mariotto AB, Besson C, Suneja G, Robien K, Younes N, Engels EA. Howlader N, et al. Among authors: younes n. Cancer. 2017 Sep 1;123(17):3326-3334. doi: 10.1002/cncr.30739. Epub 2017 May 2. Cancer. 2017. PMID: 28464214 Free article.
BACKGROUND: Survival after the diagnosis of diffuse large B-cell lymphoma (DLBCL) has been increasing since 2002 because of improved therapies; however, long-term outcomes for these patients in the modern treatment era are still unknown. ...
BACKGROUND: Survival after the diagnosis of diffuse large B-cell lymphoma (DLBCL) has been increasing since 2002 because of improved therapi …
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort.
Chen Z, Miao F, Paterson AD, Lachin JM, Zhang L, Schones DE, Wu X, Wang J, Tompkins JD, Genuth S, Braffett BH, Riggs AD; DCCT/EDIC Research Group; Natarajan R. Chen Z, et al. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E3002-11. doi: 10.1073/pnas.1603712113. Epub 2016 May 9. Proc Natl Acad Sci U S A. 2016. PMID: 27162351 Free PMC article. Clinical Trial.
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at specific loci over two different time points in people with diabetes are associated with metabolic memory, the prolonged beneficial effects of intensive vs. conventional therapy during the Diabe …
We examined whether persistence of epigenetic DNA methylation (DNA-me) alterations at specific loci over two different time points in people …
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