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Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain.
Caffino L, Piva A, Giannotti G, Di Chio M, Mottarlini F, Venniro M, Yew DT, Chiamulera C, Fumagalli F. Caffino L, et al. Among authors: yew dt. Mol Neurobiol. 2017 Nov;54(9):7186-7193. doi: 10.1007/s12035-016-0231-6. Epub 2016 Oct 29. Mol Neurobiol. 2017. PMID: 27796754 Free article.
These findings reveal a dynamic impairment of glutamate homeostasis in the mPFC and Hip that may represent a signature of long-term exposure to ketamine S/A. Further, this decrement, similarly observed in humans and animal models of schizophrenia may represent a specific f …
These findings reveal a dynamic impairment of glutamate homeostasis in the mPFC and Hip that may represent a signature of long-term e …
Short-Term Flavoxate Treatment Alters Detrusor Contractility Characteristics: Renewed Interest in Clinical Use?
Tang HC, Lam WP, Zhang X, Leung PC, Yew DT, Liang W. Tang HC, et al. Among authors: yew dt. Low Urin Tract Symptoms. 2015 Sep;7(3):149-54. doi: 10.1111/luts.12063. Epub 2014 Jun 3. Low Urin Tract Symptoms. 2015. PMID: 26663730
CONCLUSIONS: These findings provided new information of how short-term flavoxate treatment altered contractility characteristics at the bladder level, which may instill new interest in investigating the use of this drug in bladder disorders not responding well to conventio …
CONCLUSIONS: These findings provided new information of how short-term flavoxate treatment altered contractility characteristics at t …
Chronic ketamine administration modulates midbrain dopamine system in mice.
Tan S, Lam WP, Wai MS, Yu WH, Yew DT. Tan S, et al. Among authors: yew dt. PLoS One. 2012;7(8):e43947. doi: 10.1371/journal.pone.0043947. Epub 2012 Aug 24. PLoS One. 2012. PMID: 22937133 Free PMC article.
However, ketamine did not affect the expression of genes involved in DA synthesis. In the long-term (3 months) ketamine treated mice, significant increases of DA contents were found in the midbrain. ...Using western blotting, significant increases in BDNF protein levels we …
However, ketamine did not affect the expression of genes involved in DA synthesis. In the long-term (3 months) ketamine treated mice, …
Intestinal and liver changes after chronic ketamine and ketamine plus alcohol treatment.
Wong YW, Lam LH, Tang HC, Liang Y, Tan S, Yew DT. Wong YW, et al. Among authors: yew dt. Microsc Res Tech. 2012 Sep;75(9):1170-5. doi: 10.1002/jemt.22045. Epub 2012 May 23. Microsc Res Tech. 2012. PMID: 22623411
The effects of long-term chronic ketamine treatment on the intestine and the liver were studied in the ICR mice which had daily intraperitoneal injection of ketamine at 30 mg/kg per day for 7 months. ...
The effects of long-term chronic ketamine treatment on the intestine and the liver were studied in the ICR mice which had daily intra …
Long term ketamine and ketamine plus alcohol toxicity - what can we learn from animal models?
Wai MS, Luan P, Jiang Y, Chan WM, Tsui TY, Tang HC, Lam WP, Fan M, Yew DT. Wai MS, et al. Among authors: yew dt. Mini Rev Med Chem. 2013 Feb;13(2):273-9. doi: 10.2174/1389557511313020009. Mini Rev Med Chem. 2013. PMID: 22512581 Review.
Cerebellum was found to be down-regulated in both mice and humans after long-term of ketamine administration and it was caused by the apoptosis of Purkinje cells. Deleterious effects in other organs reported in long-term ketamine users include of kidney dysfunction …
Cerebellum was found to be down-regulated in both mice and humans after long-term of ketamine administration and it was caused by the …
Long-term ketamine and ketamine plus alcohol treatments produced damages in liver and kidney.
Wai MS, Chan WM, Zhang AQ, Wu Y, Yew DT. Wai MS, et al. Among authors: yew dt. Hum Exp Toxicol. 2012 Sep;31(9):877-86. doi: 10.1177/0960327112436404. Epub 2012 Feb 21. Hum Exp Toxicol. 2012. PMID: 22354085
Hydropic degenerations of the kidney tubules were observed as early as 6 weeks of treatment. Long-term ketamine administration (28 weeks) led to atresia of glomeruli in the kidney. ...
Hydropic degenerations of the kidney tubules were observed as early as 6 weeks of treatment. Long-term ketamine administration (28 we …
Mapping the central effects of chronic ketamine administration in an adolescent primate model by functional magnetic resonance imaging (fMRI).
Yu H, Li Q, Wang D, Shi L, Lu G, Sun L, Wang L, Zhu W, Mak YT, Wong N, Wang Y, Pan F, Yew DT. Yu H, et al. Among authors: yew dt. Neurotoxicology. 2012 Jan;33(1):70-7. doi: 10.1016/j.neuro.2011.11.001. Epub 2011 Dec 2. Neurotoxicology. 2012. PMID: 22178134
While the acute effects of ketamine are primarily linked to aberrant activation of the prefrontal cortex and limbic structures with elevated glutamate and dopamine levels, the long-term effects of ketamine on brain functions and neurochemical homeostasis remain incompletel …
While the acute effects of ketamine are primarily linked to aberrant activation of the prefrontal cortex and limbic structures with elevated …
Cardiotoxicity induced in mice by long term ketamine and ketamine plus alcohol treatment.
Chan WM, Liang Y, Wai MS, Hung AS, Yew DT. Chan WM, et al. Among authors: yew dt. Toxicol Lett. 2011 Nov 30;207(2):191-6. doi: 10.1016/j.toxlet.2011.09.008. Epub 2011 Sep 16. Toxicol Lett. 2011. PMID: 21945864
Although its toxicity on the central nervous system (CNS) and urinary system had been reported, its potential adverse effects on the heart is still not addressed. Using our long term ketamine addiction model in which, 1-month-old ICR mice were given ketamine intraperitonea …
Although its toxicity on the central nervous system (CNS) and urinary system had been reported, its potential adverse effects on the heart i …
Gene expression changes in GABA(A) receptors and cognition following chronic ketamine administration in mice.
Tan S, Rudd JA, Yew DT. Tan S, et al. Among authors: yew dt. PLoS One. 2011;6(6):e21328. doi: 10.1371/journal.pone.0021328. Epub 2011 Jun 21. PLoS One. 2011. PMID: 21712993 Free PMC article.
Despite its widespread use and abuse, little is known about its long-term effects on the central nervous system. The present study was designed to evaluate the effect of long-term (1- and 3-month) ketamine administration on learning and memory and associated gene ex …
Despite its widespread use and abuse, little is known about its long-term effects on the central nervous system. The present study wa …
24 results